DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tapas and Tdrd5

DIOPT Version :9

Sequence 1:	NP_611475.3	Gene:	tapas / 37304	FlyBaseID:	FBgn0027529	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	XP_006250099.1	Gene:	Tdrd5 / 289129	RGDID:	1307078	Length:	1046	Species:	Rattus norvegicus

Alignment Length:	983	Identity:	175/983 - (17%)
Similarity:	324/983 - (32%)	Gaps:	339/983 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EKQEVLEYVAKVVRALITSAKPPVTLRSIVADYMEIEGEPIPFRRLGYSNDQELLKD-SNQFNFH 65
            |::.:.:.:.|.:|:|:.|.|..:|.:.:..:|:.:.|..:|.|.|||.:..||:.| .:..:..
  Rat     3 EQERIQDCLRKEIRSLLISTKDGLTPQQLEKEYLLMVGNHLPLRILGYRSTMELVLDMPDVVSVC 67

  Fly    66 QSGN-QVFITAKYNANTEHIVRMVRQQKTSKSTSLSKPTPIAQKPKPIAQKHTHGNKYHYQQRNK 129
            ..|: .|.:.|..:.:|:.|..:|.:|:.|                             ::.||
  Rat    68 PCGDGTVILKAIPDESTKGIASLVAKQRRS-----------------------------HKVRN- 102

  Fly   130 QPNHQPDQEIGRAAKCENQAIAEHKQD--LTGIITQEL-------------FE---------SFN 170
                  ..:.||::.|..:.....:..  |..::..||             ||         ||.
  Rat   103 ------SMQKGRSSVCSGRVPYRGRVPPILPAVVKSELKDLLALSPVLLSDFEKAFARRFGRSFQ 161

  Fly   171 NIQGPFSENLQVFNKNPEYI------------TRRKKELKKEDDLDRGQITKEVAREKQKEKETR 223
            .:|..|....:|.:...:.|            .::....:|:.:...|:|..:..|.||:...:.
  Rat   162 YMQYGFLSMFEVLSAASDVICVEQTRAGSLLTLKKSASEEKQREWPAGKIFTQPFRMKQQGSYST 226

  Fly   224 DRAVTETIFVTIENKKAPVMNGHGPRHV----KVANGQDKHNDGKPPLRAILGNSASQRQQDTST 284
            ...||:|.|      ..|:.|...|:.|    |:           |....:..:..|..::
  Rat   227 GFPVTKTRF------SQPISNMEPPKQVLSMEKI-----------PMFNTVEASRLSHTEK---- 270

  Fly   285 VYHSPESSFKRPRHPRVMYPGHQRTTGVSVNHRLK---------------------VTPQSDAP- 327
             .:..||:||..    :...|...|....:.|::|                     |..:..:|
  Rat   271 -LNQLESTFKSV----IAQIGPGGTVDPDLKHKIKFVVSKFPQGLFISKLLGEFELVFKEQLSPK 330

  Fly   328 -------TPAVAPITPPASPEYAQTTTAAKATYKEDIHGGQGETGNVVTNPKVKVPLKFDPSLDP 385
                   |..|..::.....|:::.        |:|:                   |.||..|.|
  Rat   331 QLGFLNVTELVGALSDILRVEFSEE--------KQDL-------------------LVFDADLRP 368

  Fly   386 VSTLNFYCAANDFEKPAYNIFNKLRNLHCSVQ----IAGDVYSSYPQEFTDKETAYQRTA-QIAI 445
            :             .|| ...:.:|| .|.||    |..:.::|.|...:....|.::|. ...:
  Rat   369 L-------------LPA-GPLSSVRN-SCLVQPDKRIEANAWASSPSRNSLSTVAVKKTTWDCPL 418

  Fly   446 QRIMHAQSHQKLSACTFSDVEFIDGLYKELLKHPHGILGHKLEDWYGSTFRQHLPSHWYDLIVKS 510
            :.  |.::.||              .||:                         |    :|:||.
  Rat   419 KN--HKEAEQK--------------AYKK-------------------------P----NLVVKP 438

  Fly   511 NKIRVEHGIDPRIILFANDPGSSEPDRT---SITTLPQMVLPWQSSE--GGSHDWNMFISFCDST 570
            .:::||.......:..||.  ...||..   .:..||    |..:|.  |      :|:.:..|.
  Rat   439 LQLQVETNKSQLSLSMANH--DIPPDAVRAKKLCRLP----PLDTSTLVG------VFVEYIISP 491

  Fly   571 KIVWARMIDQIANFEELTKHIGRQMESPHFRQKVSKPYAQEVYLVE----------MPDGWNRV- 624
            ...:.|:..:  :..||.:.:..:|...:..|.||..|....|.::          ....|.||
  Rat   492 SQFYVRIYSR--DSSELLEDMMIEMRRCYSNQLVSDRYVMPEYFIQPGHLCCVRISEDKWWYRVI 554

  Fly   625 --RAISVDEETRSGRYHFIDFGDVAMFHSEDLFHCPPQFLALPAQAVCLSMYALDKFEDHPHALQ 687
              |.:...|.    ...:.|||::.......|......:..|||||:..|:..:...|:|..:..
  Rat   555 IHRILGKKEV----EVFYPDFGNIGTVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPAEEHWTSKA 615

  Fly   688 VLTKELDGQTVVAHVLTTEKQFLELGG--SAQGVVE---NGKRRACLVATLYDTSTAEDIHLNDL 747
            :|                  .|.:|.|  ...|||:   :|    .|...|.|||:.||::.:.:
  Rat   616 IL------------------HFQKLCGLKPLVGVVDEYIDG----ILNIFLCDTSSNEDVYFHHV 658

  Fly   748 VAKR-----------------------ITKCTPAPSLSDEKKIGKTTPILVSHINDDGDLMVLLR 789
            :...                       .|..:.||......::|.  |....::|:||::
  Rat   659 LRTEGHAIVCRENAPSKGFRDFNPPALYTNSSAAPGDMVLTELGH--PAQQHYLNEDGEI----- 716

  Fly   790 NDDLKFVERSIAQTVADLGEQDRVSY-----SDLLHDRHI--FVCDETVDGVKQWFRGRLVTRPL 847
                      :.|...|:.::..:|:     .:||.|..:  ....|:.:...||    .:.:|.
  Rat   717 ----------LQQPQQDINDEKSISHLKSVSEELLKDSKLGPLKTRESCEEEPQW----SILKPK 767

  Fly   848 NPDEESFD 855
            :|.||:.|
  Rat   768 DPKEENED 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tapas	NP_611475.3	LOTUS_TDRD_OSKAR	7..92	CDD:193586	22/86 (26%)
		TUDOR	563..673	CDD:278965	25/122 (20%)
		TUDOR	766..896	CDD:278965	19/97 (20%)
		TUDOR	1032..1151	CDD:278965
		TUDOR	1087..1131	CDD:119391
Tdrd5	XP_006250099.1	LOTUS_1_TDRD5	4..98	CDD:193599	24/122 (20%)
		LOTUS_2_TDRD5	127..196	CDD:193589	10/68 (15%)
		LOTUS_3_TDRD5	292..365	CDD:193590	12/99 (12%)
		TUDOR	483..602	CDD:278965	26/124 (21%)
		TUDOR	537..583	CDD:119391	8/49 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810