DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tapas and Tdrd6

DIOPT Version :9

Sequence 1:	NP_611475.3	Gene:	tapas / 37304	FlyBaseID:	FBgn0027529	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001154838.1	Gene:	Tdrd6 / 210510	MGIID:	2679727	Length:	2135	Species:	Mus musculus

Alignment Length:	770	Identity:	165/770 - (21%)
Similarity:	282/770 - (36%)	Gaps:	200/770 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   530 PGSSEPDRTSITTLPQMVLPWQSSEGGSHDWNMF-------------ISFCDSTKIVWARMIDQI 581
            ||:|...|.|...:...|:|.|.       |.:.             |....:|:..||
Mouse    10 PGASLALRVSFVDVHPEVIPVQL-------WGLVGQRREEYVRLSREIQEAAATRGPWA------ 61

  Fly   582 ANFEELTKHIGRQMESPHFRQKVSKPYAQEVYLVEMPDGWNRVRAISVDEETRSGRYHFID---- 642
                     :|....||           .|:.||::...|:|.|.:|  .:.:..|...:|
Mouse    62 ---------LGGASASP-----------GELCLVQVGLMWHRCRVVS--RQAQDSRVFLLDEGRT 104

  Fly   643 ----FGDVAMFHSEDLFHCPPQFLA------LPA---------------QAVCLSMYALDKFEDH 682
                .|.:|...|| .||.|.:.|.      :||               :||.. :..|...|.|
Mouse   105 ITAGAGSLAPGRSE-FFHLPSEVLGCVLAGLVPAGGGGTGGGEPQQWSPRAVDF-LSNLQGKEVH 167

  Fly   683 PHALQVLTKELDGQTVVAHVLTTEKQFLELGGSAQGVVENGKRRACLVATLYDTSTAEDIHLNDL 747
            ...|.||   |..:.|:..|....:|..|| |.|:.|.::   ..|.:...|.|:..:    ...
Mouse   168 GRVLDVL---LLHRLVLLEVPVVSQQMEEL-GLARQVPDS---LFCSLLKRYLTAAGQ----GSS 221

  Fly   748 VAKRITKCTPA---PSLS---DEKKIGKTTPILVSHINDDGDLMVLLR--NDDLKFVERSIAQTV 804
            .|..:.:..|.   |.|.   .:.::|.|.|::|:.:.....:...||  :.::..:..|:||..
Mouse   222 GAPVLPRAAPKQEHPGLDYFYPQLQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVY 286

  Fly   805 -ADLGEQDRVSYSDLLHDRHIFVCDET------------VDGVKQWFRGRLVT--RPLNPDEESF 854
             |.:|..|..|.|....:|     :|:            :||  ||:|..|:.  ||    :...
Mouse   287 RAPVGTDDEDSGSATWEER-----EESPDKPGSPCASCGLDG--QWYRALLLETFRP----QRCA 340

  Fly   855 DVYYVDDGRQRKAHISNI-YRLEANNRALATFPPQAIPVRLHDVPEIGGHMLHRLRGLIPWRTEA 918
            .|.:||.||:.....|:: |.|....|    .|....|..|:.:.:.|       ||   |....
Mouse   341 QVLHVDYGRKELVSCSSLRYLLPEYFR----MPVVTYPCALYGLWDCG-------RG---WSRSQ 391

  Fly   919 LLKVVAMDGGKPLVNVFIRE--DPESMYMC-------VNIGLRLELEMASSIHPEKYDHTLLSSN 974
            :..:.|:..|: .||..|..  ..|.||..       :|:.....::.....     |..|.|..
Mouse   392 VGDLKALILGQ-AVNAKIEFYCSFEHMYYVTLYGEDGINLNSAFGVQSCCLA-----DWFLQSQG 450

  Fly   975 VQLPR---RGSFSSVFSNQSSSSDLVATTPPVTPEKKPSARSTGSTFSSLMLKDYEAIPAVGAYF 1036
            ::...   .....:.|.:||.:.::.|..      ..||.|       |:.||       :..::
Mouse   451 IEEEEEEDEDEVEAAFQSQSPAEEMEAEV------SLPSLR-------SIRLK-------MNTFY 495

  Fly  1037 EVRVALSVNPGHFAVQPYKYYNQLQTLMKNLQEHCQ--KTAAK--GV----QPSQLAIGEAYAAP 1093
            :.:|....:|..|.::..|:.|....|.|.:   |.  .:|:|  ||    :|..|.     ...
Mouse   496 DAQVEFVKSPSEFWIRLRKHKNTFSKLTKRM---CSFYSSASKLDGVILRPEPDDLC-----CVK 552

  Fly  1094 DSEGVYHRVSIHKIYDEIIHVRFVDVGD-DGVIACDQLKTLNPELRKLPKMALPAQLYGIQLTDV 1157
            ..|..|:|.::.::..:.:.|..||.|: :.|..|| ::.|.|:.|:||.:||...|..|.....
Mouse   553 WKENGYYRATVTRLDSKSVDVFLVDRGNSENVDWCD-VRMLLPQFRQLPILALKCTLADIWPLGK 616

  Fly  1158 VWSKENCVRFRELSLGQKFIGIVRRMTKQKDGGRALCLELVDTSTPKDIKLHEIL 1212
            .||:|....|::..|.::.  :|..:.||   .....:|::|.|...:..:.:::
Mouse   617 TWSQEATSFFKKTVLHKEL--VVHVLDKQ---DHQYVIEILDESRMGEENISKVI 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tapas	NP_611475.3	LOTUS_TDRD_OSKAR	7..92	CDD:193586
		TUDOR	563..673	CDD:278965	28/151 (19%)
		TUDOR	766..896	CDD:278965	36/147 (24%)
		TUDOR	1032..1151	CDD:278965	32/127 (25%)
		TUDOR	1087..1131	CDD:119391	10/44 (23%)
Tdrd6	NP_001154838.1	TUDOR	10..133	CDD:278965	33/158 (21%)
		TUDOR	245..379	CDD:278965	36/148 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..315		7/32 (22%)
		TUDOR	313..359	CDD:119391	14/51 (27%)
		TUDOR	489..610	CDD:278965	34/136 (25%)
		TUDOR	547..591	CDD:119391	11/49 (22%)
		TUDOR	773..890	CDD:278965
		TUDOR	826..869	CDD:119391
		TUDOR	987..1106	CDD:278965
		TUDOR	1042..1084	CDD:119391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1296
		TUDOR	1309..1428	CDD:278965
		TUDOR	1362..1406	CDD:119391
		TUDOR	1519..1641	CDD:278965
		TUDOR	1574..1621	CDD:119391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1699..1733
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1860..1885
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1930..1987
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22948
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4998
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910