DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11200 and Wwox

DIOPT Version :9

Sequence 1:	NP_001286630.1	Gene:	CG11200 / 37301	FlyBaseID:	FBgn0034500	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_062519.2	Gene:	Wwox / 80707	MGIID:	1931237	Length:	414	Species:	Mus musculus

Alignment Length:	270	Identity:	81/270 - (30%)
Similarity:	129/270 - (47%)	Gaps:	35/270 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 RIAVITGGNRGIGLRIVEKLLACDMTVVMGVRDPKIAETAVASIVDLNATKGKLICEQLDVGDLK 132
            ::.::||.|.|||....:........|::..|:...|..||:.|:: ...|.|:....||:..|:
Mouse   125 KVVLVTGANSGIGFETAKSFALHGAHVILACRNLSRASEAVSRILE-EWHKAKVEAMTLDLAVLR 188

  Fly   133 SVKAFAQLIKERYSKVDLLLNNAGIMFAPFKLTADGYESHFAINFLGHFLLTHLLLPQLRAAGKE 197
            ||:.||:..|.:...:.:|:.|||....|:.||.||.|:.|.:|.||||.|..||...|..:..
Mouse   189 SVQHFAEAFKAKNVSLHVLVCNAGTFALPWGLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSSP- 252

  Fly   198 GRNSRIVNVSSCVNLIGRINYKDINGT-------------KHYYPGTAYSQSKLAQILFTRHLQT 249
               :|::.|||..:     .:.|||.:             ..|:...||::|||..|||:..|..
Mouse   253 ---ARVIVVSSESH-----RFTDINDSSGKLDLSRLSPPRSDYWAMLAYNRSKLCNILFSNELHR 309

  Fly   250 LLDAEKSHVQVNVVHPGIVDTDLFEHSATTSVPIFKKL------FFKTPERGSRTVVFAAIDPSI 308
            .|...  .|..|.||||    ::...:...:..::|.|      |.|:.::|:.|.|:.|:.|.:
Mouse   310 RLSPR--GVTSNAVHPG----NMMYSAIHRNSWVYKLLFTLARPFTKSMQQGAATTVYCAVAPEL 368

  Fly   309 EGQGGTYLSN 318
            ||.||.|.:|
Mouse   369 EGLGGMYFNN 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11200	NP_001286630.1	PRK06196	56..344	CDD:235736	81/270 (30%)
CG11200	NP_001286630.1	NADB_Rossmann	67..338	CDD:304358	81/270 (30%)
Wwox	NP_062519.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		WW	19..47	CDD:238122
		Nuclear localization signal	50..55
		WW	60..90	CDD:238122
		PRK06196	107..404	CDD:235736	81/270 (30%)
		human_WWOX_like_SDR_c-like	124..407	CDD:187669	81/270 (30%)
		Interaction with MAPT. /evidence=ECO:0000269\|PubMed:15126504	125..414		81/270 (30%)
		Mediates targeting to the mitochondria	209..273		26/72 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810