DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11200 and wwox

DIOPT Version :9

Sequence 1:	NP_001286630.1	Gene:	CG11200 / 37301	FlyBaseID:	FBgn0034500	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_957207.1	Gene:	wwox / 393887	ZFINID:	ZDB-GENE-040426-858	Length:	412	Species:	Danio rerio

Alignment Length:	330	Identity:	93/330 - (28%)
Similarity:	156/330 - (47%)	Gaps:	31/330 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KSWFEWKTEFRYQYLGIVGLVHDAQYKARDRVALYKQPDRIAVITGGNRGIGLRIVEKLLACDMT 93
            |::|:.:..|..:.:.:....:|....|.:.:......|::.::||.|.|||.............
Zfish    83 KTYFDPRQAFTVEDMQVKPKRYDGNTGALEILHGQDLSDKVIIVTGANSGIGFETARSFALHGAH 147

  Fly    94 VVMGVRDPKIAETAVASIVDLNATKGKLICEQLDVGDLKSVKAFAQLIKERYSKVDLLLNNAGIM 158
            |::..|:...|..| ||::....:|.::....||:..|:||:.||:|.|.....:.:|:.||.:.
Zfish   148 VILACRNQSRASKA-ASLIMGEWSKARVEVLPLDLASLRSVRQFAELFKATKLPLHVLVCNAAVC 211

  Fly   159 FAPFKLTADGYESHFAINFLGHFLLTHLLLPQLRAAGKEGRNSRIVNVS-----------SCVNL 212
            ..|::||.||:||.|.|..||||||..||...||.:..    :|:|.||           ||.||
Zfish   212 SQPWRLTEDGFESTFQICHLGHFLLVQLLQDVLRLSAP----ARVVVVSSESHRFTDLLDSCGNL 272

  Fly   213 IGRINYKDIN----GTKHYYPGTAYSQSKLAQILFTRHLQTLLDAEKSHVQVNVVHPGIVDTDLF 273
                   |::    ..|:|:...||:::||..:||:..|...:...  .:..|.:|||.:.....
Zfish   273 -------DLDLLSPPQKNYWSLLAYNRAKLCNLLFSSELHRRMSPH--GICCNALHPGSMMFTSI 328

  Fly   274 EHSATTSVPIFK--KLFFKTPERGSRTVVFAAIDPSIEGQGGTYLSNGGKGPFHPDAKKPAKCEQ 336
            ..|......:|.  :.|.|:.::|:.|.|:.|:.|.:||.||.|.:|..:....|.|:.||....
Zfish   329 HRSWWLLTLLFSLARPFTKSMQQGAATTVYCAVAPELEGIGGMYFNNCFRCLPSPQAQDPAAALS 393

  Fly   337 LFQFS 341
            |::.|
Zfish   394 LWELS 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11200	NP_001286630.1	PRK06196	56..344	CDD:235736	89/303 (29%)
CG11200	NP_001286630.1	NADB_Rossmann	67..338	CDD:304358	86/287 (30%)
wwox	NP_957207.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		WW	18..47	CDD:278809
		Nuclear localization signal. /evidence=ECO:0000250	50..55
		WW	59..88	CDD:278809	2/4 (50%)
		PRK06196	108..402	CDD:235736	89/305 (29%)
		human_WWOX_like_SDR_c-like	121..404	CDD:187669	88/292 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910