DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11200 and Wwox

DIOPT Version :9

Sequence 1:	NP_001286630.1	Gene:	CG11200 / 37301	FlyBaseID:	FBgn0034500	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster

Alignment Length:	298	Identity:	79/298 - (26%)
Similarity:	136/298 - (45%)	Gaps:	39/298 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 RIAVITGGNRGIGLRIVEKLLACDMTVVMGVRDPKIAETAVASIV-DLNATKGKLICEQLDVGDL 131
            |.|:|||.|.|||......|......::...|:...||.|:..|. :..|.:.:.....||:..|
  Fly   122 RTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLSSL 186

  Fly   132 KSVKAFAQLIKERYSKVDLLLNNAGIMFAPFKLTADGYESHFAINFLGHFLLTHLLLPQLRAAGK 196
            :||:.|.:.||:..|.:|.|:.|||:...|:..|.||.|:.|.::.|.||.||      |:....
  Fly   187 RSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLT------LQLETL 245

  Fly   197 EGRNSRIVNVSSCVNLIGRINYKDINGTKH-------YYPGTAYSQSKLAQILFTRHLQTLLDAE 254
            ....:||:.:||..:....:..::: ...|       |:...||:.:||..:||.:.|....  :
  Fly   246 FDYKTRIIVLSSESHRFANLPVENL-AVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRW--K 307

  Fly   255 KSHVQVNVVHPG-IVDTDLFEHSATTSVPIFKKLFF-------KTPERGSRTVVFAAIDPSIEGQ 311
            :..:.|..:||| :|.:||..:.      .|.:|.|       |:.::.:.|.::.|....:.|.
  Fly   308 QRGISVFSLHPGNMVSSDLSRNY------WFYRLLFAIVRPFTKSLQQAAATSIYCATANELTGL 366

  Fly   312 GGTYLSNGGKGPFHPDAKKPAKC----EQLFQFSCDLL 345
            .|.|.:|    .|..:..|.:|.    :||::.|.:|:
  Fly   367 SGLYFNN----CFFCEPSKLSKSAALQQQLWKLSENLI 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11200	NP_001286630.1	PRK06196	56..344	CDD:235736	78/295 (26%)
CG11200	NP_001286630.1	NADB_Rossmann	67..338	CDD:304358	76/289 (26%)
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	79/298 (27%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	79/298 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I2553
eggNOG	1	0.900	-	-		E2759_KOG1208
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	113	1.000	Inparanoid score	I1353
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24320
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.960