DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG16868 and CACNA2D4

DIOPT Version :9

Sequence 1:NP_611469.1 Gene:CG16868 / 37298 FlyBaseID:FBgn0034498 Length:1449 Species:Drosophila melanogaster
Sequence 2:NP_758952.4 Gene:CACNA2D4 / 93589 HGNCID:20202 Length:1137 Species:Homo sapiens


Alignment Length:1177 Identity:215/1177 - (18%)
Similarity:395/1177 - (33%) Gaps:351/1177 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 RYNLTKVWQYSYDDEDDESESEMDLEMELEDLHARNTASPTDEHVQLYLNTQIESCQ----PDYE 211
            :|:.:.:.|..|.|        ::..:::|::..........|.::..|..::|:.|    ...|
Human    94 KYSGSLLLQKKYKD--------VESSLKIEEVDGLELVRKFSEDMENMLRRKVEAVQNLVEAAEE 150

  Fly   212 TDLEYGSSSTQSIHYNRQQIQILNYLKSD------DARATFLNENNAR--SLAVNGYISN-QL-- 265
            .||.:  ...:|:.::.....::|  :.|      :..|.||.|:||.  :|.||..||: ||  
Human   151 ADLNH--EFNESLVFDYYNSVLIN--ERDEKGNFVELGAEFLLESNAHFSNLPVNTSISSVQLPT 211

  Fly   266 ------------VLLKRRLSRSDAENSNSKPI-------SGNHFKHIY----FLSNSDGA-SASL 306
                        |.:...|:....||....|.       |...|..||    :..:.:|. :...
Human   212 NVYNKDPDILNGVYMSEALNAVFVENFQRDPTLTWQYFGSATGFFRIYPGIKWTPDENGVITFDC 276

  Fly   307 HFRQLYV-SAIKQKFVLFLIDVGSALSAELFDLSKSFVHEMLQLLEDTDKVSLVTVASEANFMSL 370
            ..|..|: :|...|.::.|:||..::......::|..:..:|..|.:.|.::::......:::. 
Human   277 RNRGWYIQAATSPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIE- 340

  Fly   371 EAFPAEAGHGIYSATRAHKEEIISFINSLS-RAQAFTNHSLGFEYSFELLHRLQQSGMINTAEQP 434
               |...|. :..|.|.::|.....:..|. :.....:.:|  ..:|::|.:.|::         
Human   341 ---PCFKGI-LVQADRDNREHFKLLVEELMVKGVGVVDQAL--REAFQILKQFQEA--------- 390

  Fly   435 VEFVYITRGLLTNLSDAMAVLRVVADGQRRLRAPVIIN----TCAVVLDEKRIMYEKQFLNDV-- 493
                  .:|.|.|     ..:.:::||......||...    .|.|.:....|..|..|.:.:  
Human   391 ------KQGSLCN-----QAIMLISDGAVEDYEPVFEKYNWPDCKVRVFTYLIGREVSFADRMKW 444

  Fly   494 ASQNYTKYEIDVASWWPSGQEASELVGRFYVLSKMHAETSLPQTSSRIFGPLFQERYLSDTLEVH 558
            .:.|...|...:::...:.:...|.:   :|||:       |...:.....::.|.|:...|   
Human   445 IACNNKGYYTQISTLADTQENVMEYL---HVLSR-------PMVINHDHDIIWTEAYMDSKL--- 496

  Fly   559 PPVVDADSGDVLVSITHAVPPY-------------GVVGVNLYLSDLLEDLLNYPSTTSSAKQGL 610
               :.:.:..:.:..|.|:|.:             ||||.::.|.:|::....|       |.|:
Human   497 ---LSSQAQSLTLLTTVAMPVFSKKNETRSHGILLGVVGSDVALRELMKLAPRY-------KLGV 551

  Fly   611 -GYAFLLDRSTGNTLAHPAFPRPLIQRETSYPVNIAYLENATDFS--------SHIRDRLLREES 666
             |||| |:.:.|..|:||.. |||.:..........|  |:.|.|        ..:|..::..|:
Human   552 HGYAF-LNTNNGYILSHPDL-RPLYREGKKLKPKPNY--NSVDLSEVEWEDQAESLRTAMINRET 612

  Fly   667 GNVTTDVYVGRQRLQRTYYWQSVLGF-------YVLCLVSSGGDTLRNVSSTQRYNLKDTVSNYE 724
            |.::.||.|...:.:|..:..:...|       :.|.:|.|.|.        ..|.|....| .|
Human   613 GTLSMDVKVPMDKGKRVLFLTNDYFFTDISDTPFSLGVVLSRGH--------GEYILLGNTS-VE 668

  Fly   725 PGYYGESMDLLYHRLDLNQGGSAPPKTCRYFRQVATMDAPTLFLSAAAFESPFGFLHNNRPRTQL 789
            .|.:    |||:.  ||...|.       :...:..:|.....||  ..|:...||....|..:.
Human   669 EGLH----DLLHP--DLALAGD-------WIYCITDIDPDHRKLS--QLEAMIRFLTRKDPDLEC 718

  Fly   790 RHVESIMAYLRDS----------SGLLANMGLRPSIRHEVGVLYQAMQQLRRRHQDARGSLRSHV 844
            .. |.:...|.|:          :.|..||.  ....|.|.:.:...:         .|.|||.:
Human   719 DE-ELVREVLFDAVVTAPMEAYWTALALNMS--EESEHVVDMAFLGTR---------AGLLRSSL 771

  Fly   845 I--------RRYI-----ASVSGVLQLYPGCLLSSSYDPTRRPWFRQAIAQP-GKIVSTAPYL-- 893
            .        |:::     |||. .|..:|             .|:|||...| |..|....:.  
Human   772 FVGSEKVSDRKFLTPEDEASVF-TLDRFP-------------LWYRQASEHPAGSFVFNLRWAEG 822

  Fly   894 -DAGGAGYIITIAHTIFEGKAHALHSAQQDRPVAVVA---LDVPYAFYYRLI---------LEG- 944
             ::.|...::|.:..:         :...|:..|:.|   :.:...|..|..         ::| 
Human   823 PESAGEPMVVTASTAV---------AVTVDKRTAIAAAAGVQMKLEFLQRKFWAATRQCSTVDGP 878

  Fly   945 -TPICQLPHIKCLLFEHEGYLLAHPSMLQPATLTKNQRRPHEHLTHKESYLANDMLNHGQLVR-- 1006
             |..|:...:.|.:.::.|::|          ::|..|.....|...:..:...:|:.|...:  
Human   879 CTQSCEDSDLDCFVIDNNGFIL----------ISKRSRETGRFLGEVDGAVLTQLLSMGVFSQVT 933

  Fly  1007 ----KLGC--ASYQNRTLQRYY----AFNTSLSSILGNVV------------------------H 1037
                :..|  :|:.:...|...    ||.|:...:|..:|                        |
Human   934 MYDYQAMCKPSSHHHSAAQPLVSPISAFLTATRWLLQELVLFLLEWSVWGSWYDRGAEAKSVFHH 998

  Fly  1038 GERTK------------------------------------YAIALIRGSNLFAAVLNSSCDGGA 1066
            ..:.|                                    :.:..|..|||...|.:.:||...
Human   999 SHKHKKQDPLQPCDTEYPVFVYQPAIREANGIVECGPCQKVFVVQQIPNSNLLLLVTDPTCDCSI 1063

  Fly  1067 FCPCSTIDRE-----CLNCKRMDQ-------TDC------ECPCECPMVGD-SSSPSSLMYFANY 1112
            |.|......|     .:.|.||..       ..|      |...:|....| |:||..|:     
Human  1064 FPPVLQEATEVKYNASVKCDRMRSQKLRRRPDSCHAFHPEENAQDCGGASDTSASPPLLL----- 1123

  Fly  1113 TRQFPYC 1119
               .|.|
Human  1124 ---LPVC 1127

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG16868NP_611469.1 vWFA 308..>426 CDD:294047 21/119 (18%)
Cache_1 559..627 CDD:280839 19/81 (23%)
CACNA2D4NP_758952.4 VWA_N 148..264 CDD:285584 28/119 (24%)
vWA_VGCC_like 277..460 CDD:238740 35/209 (17%)
MIDAS-like motif 297..301 2/3 (67%)
Cache_1 487..579 CDD:280839 27/106 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2353
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.