Protein Alignment CG16868 and CACNA2D4

DIOPT Version :10

• Sequence 1: NP_611469.1
• Gene: CG16868 / 37298
• FlyBaseID: FBgn0034498
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: NP_758952.4
• Gene: CACNA2D4 / 93589
• HGNCID: 20202
• Length: 1137
• Species: Homo sapiens
• Alignment Length: 1176
• Identity: 216/1176 - (18%)
• Similarity: 396/1176 - (33%)
• Gaps: 349/1176 - (29%)

  Fly   151 RYNLTKVWQYSYDDEDDESESEMDLEMELEDLHARNTASPTDEHVQLYLNTQIESCQ----PDYE 211
            :|:.:.:.|..|.|        ::..:::|::..........|.::..|..::|:.|    ...|
Human    94 KYSGSLLLQKKYKD--------VESSLKIEEVDGLELVRKFSEDMENMLRRKVEAVQNLVEAAEE 150

  Fly   212 TDLEYG-SSSTQSIHYN----RQQIQILNYLKSDDARATFLNENNAR--SLAVNGYISN-QL--- 265
            .||.:. :.|....:||    .::.:..|::   :..|.||.|:||.  :|.||..||: ||
Human   151 ADLNHEFNESLVFDYYNSVLINERDEKGNFV---ELGAEFLLESNAHFSNLPVNTSISSVQLPTN 212

  Fly   266 -----------VLLKRRLSRSDAENSNSKPI-------SGNHFKHIY----FLSNSDGA-SASLH 307
                       |.:...|:....||....|.       |...|..||    :..:.:|. :....
Human   213 VYNKDPDILNGVYMSEALNAVFVENFQRDPTLTWQYFGSATGFFRIYPGIKWTPDENGVITFDCR 277

  Fly   308 FRQLYV-SAIKQKFVLFLIDVGSALSAELFDLSKSFVHEMLQLLEDTDKVSLVTVASEANFMSLE 371
            .|..|: :|...|.::.|:||..::......::|..:..:|..|.:.|.::::......:::.
Human   278 NRGWYIQAATSPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIE-- 340

  Fly   372 AFPAEAGHGIYSATRAHKEEIISFINSLS-RAQAFTNHSLGFEYSFELLHRLQQSGMINTAEQPV 435
              |...|. :..|.|.::|.....:..|. :.....:.:|  ..:|::|.:.|::
Human   341 --PCFKGI-LVQADRDNREHFKLLVEELMVKGVGVVDQAL--REAFQILKQFQEA---------- 390

  Fly   436 EFVYITRGLLTNLSDAMAVLRVVADGQRRLRAPVIIN----TCAVVLDEKRIMYEKQFLNDV--A 494
                 .:|.|.|     ..:.:::||......||...    .|.|.:....|..|..|.:.:  .
Human   391 -----KQGSLCN-----QAIMLISDGAVEDYEPVFEKYNWPDCKVRVFTYLIGREVSFADRMKWI 445

  Fly   495 SQNYTKYEIDVASWWPSGQEASELVGRFYVLSKMHAETSLPQTSSRIFGPLFQERYLSDTLEVHP 559
            :.|...|...:::...:.:...|.:   :|||:       |...:.....::.|.|:...|
Human   446 ACNNKGYYTQISTLADTQENVMEYL---HVLSR-------PMVINHDHDIIWTEAYMDSKL---- 496

  Fly   560 PVVDADSGDVLVSITHAVPPY-------------GVVGVNLYLSDLLEDLLNYPSTTSSAKQGL- 610
              :.:.:..:.:..|.|:|.:             ||||.::.|.:|::....|       |.|:
Human   497 --LSSQAQSLTLLTTVAMPVFSKKNETRSHGILLGVVGSDVALRELMKLAPRY-------KLGVH 552

  Fly   611 GYAFLLDRSTGNTLAHPAFPRPLIQRETSYPVNIAYLENATDFS--------SHIRDRLLREESG 667
            |||| |:.:.|..|:||.. |||.:..........|  |:.|.|        ..:|..::..|:|
Human   553 GYAF-LNTNNGYILSHPDL-RPLYREGKKLKPKPNY--NSVDLSEVEWEDQAESLRTAMINRETG 613

  Fly   668 NVTTDVYVGRQRLQRTYYWQSVLGF-------YVLCLVSSGGDTLRNVSSTQRYNLKDTVSNYEP 725
            .::.||.|...:.:|..:..:...|       :.|.:|.|.|.        ..|.|....| .|.
Human   614 TLSMDVKVPMDKGKRVLFLTNDYFFTDISDTPFSLGVVLSRGH--------GEYILLGNTS-VEE 669

  Fly   726 GYYGESMDLLYHRLDLNQGGSAPPKTCRYFRQVATMDAPTLFLSAAAFESPFGFLHNNRPRTQLR 790
            |.:    |||:.  ||...|.       :...:..:|.....||  ..|:...||....|..:..
Human   670 GLH----DLLHP--DLALAGD-------WIYCITDIDPDHRKLS--QLEAMIRFLTRKDPDLECD 719

  Fly   791 HVESIMAYLRDS----------SGLLANMGLRPSIRHEVGVLYQAMQQLRRRHQDARGSLRSHVI 845
            . |.:...|.|:          :.|..||.  ....|.|.:.:...:         .|.|||.:.
Human   720 E-ELVREVLFDAVVTAPMEAYWTALALNMS--EESEHVVDMAFLGTR---------AGLLRSSLF 772

  Fly   846 --------RRYI-----ASVSGVLQLYPGCLLSSSYDPTRRPWFRQAIAQP-GKIVSTAPYL--- 893
                    |:::     |||. .|..:|             .|:|||...| |..|....:.
Human   773 VGSEKVSDRKFLTPEDEASVF-TLDRFP-------------LWYRQASEHPAGSFVFNLRWAEGP 823

  Fly   894 DAGGAGYIITIAHTIFEGKAHALHSAQQDRPVAVVA---LDVPYAFYYRLI---------LEG-- 944
            ::.|...::|.:..:         :...|:..|:.|   :.:...|..|..         ::|
Human   824 ESAGEPMVVTASTAV---------AVTVDKRTAIAAAAGVQMKLEFLQRKFWAATRQCSTVDGPC 879

  Fly   945 TPICQLPHIKCLLFEHEGYLLAHPSMLQPATLTKNQRRPHEHLTHKESYLANDMLNHGQLVR--- 1006
            |..|:...:.|.:.::.|::|          ::|..|.....|...:..:...:|:.|...:
Human   880 TQSCEDSDLDCFVIDNNGFIL----------ISKRSRETGRFLGEVDGAVLTQLLSMGVFSQVTM 934

  Fly  1007 ---KLGC--ASYQNRTLQRYY----AFNTSLSSILGNVV------------------------HG 1038
               :..|  :|:.:...|...    ||.|:...:|..:|                        |.
Human   935 YDYQAMCKPSSHHHSAAQPLVSPISAFLTATRWLLQELVLFLLEWSVWGSWYDRGAEAKSVFHHS 999

  Fly  1039 ERTK------------------------------------YAIALIRGSNLFAAVLNSSCDGGAF 1067
            .:.|                                    :.:..|..|||...|.:.:||...|
Human  1000 HKHKKQDPLQPCDTEYPVFVYQPAIREANGIVECGPCQKVFVVQQIPNSNLLLLVTDPTCDCSIF 1064

  Fly  1068 CPCSTIDRE-----CLNCKRMDQ-------TDC------ECPCECPMVGD-SSSPSSLMYFANYT 1113
            .|......|     .:.|.||..       ..|      |...:|....| |:||..|:
Human  1065 PPVLQEATEVKYNASVKCDRMRSQKLRRRPDSCHAFHPEENAQDCGGASDTSASPPLLL------ 1123

  Fly  1114 RQFPYC 1119
              .|.|
Human  1124 --LPVC 1127

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16868	NP_611469.1	vWFA	308..>426	CDD:469594	21/119 (18%)
		HK_sensor	<867..933	CDD:365792	12/72 (17%)
CACNA2D4	NP_758952.4	VWA_N	148..264	CDD:462464	29/118 (25%)
		vWA_VGCC_like	277..460	CDD:238740	35/209 (17%)
		MIDAS-like motif	297..301		2/3 (67%)
		HK_sensor	<484..537	CDD:365792	10/58 (17%)
		HK_sensor	539..654	CDD:365792	30/125 (24%)
		VGCC_alpha2	661..1110	CDD:462488	85/509 (17%)