DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16868 and CACNA2D2

DIOPT Version :9

Sequence 1:	NP_611469.1	Gene:	CG16868 / 37298	FlyBaseID:	FBgn0034498	Length:	1449	Species:	Drosophila melanogaster
Sequence 2:	XP_011532545.1	Gene:	CACNA2D2 / 9254	HGNCID:	1400	Length:	1151	Species:	Homo sapiens

Alignment Length:	1299	Identity:	236/1299 - (18%)
Similarity:	433/1299 - (33%)	Gaps:	468/1299 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PTSSQHVPLAMANSTSNQVPTDPGFMPLQQSPGS---VFFVHHNQQN-AMQLRHSMEGKLRNIRN 80
            |||....||.:.      :|    .:||..:||:   .|...|..|: |.:|...::|.:|....
Human    36 PTSGPPRPLWLL------LP----LLPLLAAPGASAYSFPQQHTMQHWARRLEQEVDGVMRIFGG 90

  Fly    81 TELRVAKIQEIFDSMHFSSAKGASNTRQASSNDSNVVNPQLQRDLQLFSERLSKKIQKATYVVLE 145
                |.:::||:        |...|..:...|:...:..::..|::...:|..:.:::.......
Human    91 ----VQQLREIY--------KDNRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAEN 143

  Fly   146 LRELLRYNLTKVWQYSYDDE-----DDESESEMDLEMELEDLHARNTASPTDEHVQLYLNTQIES 205
            .::..|      ||.:..:|     |.::::|:| :.|.||:...:.||      .|.|:. ||
Human   144 FQKAHR------WQDNIKEEDIVYYDAKADAELD-DPESEDVERGSKAS------TLRLDF-IE- 193

  Fly   206 CQPDYETDLEYGSSSTQ---SIHYNRQQIQILNYLKSDDARATFLNENNARSLAVNGYISNQLVL 267
             .|:::..:.|..::.|   .|:  :....|||.|...:|......||..:...:...:......
Human   194 -DPNFKNKVNYSYAAVQIPTDIY--KGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATG 255

  Fly   268 LKRRLSRSDAENSNSKPISGNHFKHIYFLSNSDGASASLHF-----RQLYV-SAIKQKFVLFLID 326
            :.|                       |:.:....|...:..     |..|: .|...|.::.::|
Human   256 VTR-----------------------YYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVD 297

  Fly   327 VGSALSAELFDLSKSFVHEMLQLLEDTDKVSLVTVASEANFMSLEAFPAEAGHGIYSATRAHKEE 391
            |..::|.....|.|:.|.|||..|.|.|.|::.:...:|..:|......:|.   ....:..||.
Human   298 VSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQAN---VRNKKVFKEA 359

  Fly   392 IISFINSLSRAQAFTNHSLGFEYSFELLHRLQQSGMINTAEQPVEFVYITRGLLTNLSDAMAVLR 456
            :...:     |:..|.:..||||:|:   :||.|.             |||      ::...::.
Human   360 VQGMV-----AKGTTGYKAGFEYAFD---QLQNSN-------------ITR------ANCNKMIM 397

  Fly   457 VVADGQRRLRAPVIINTCAVVLDEKRIMYEKQ---------FLNDVASQNYTKYEIDVASWW--- 509
            :..||..               |..:.::||.         |...|...|   |::....|.
Human   398 MFTDGGE---------------DRVQDVFEKYNWPNRTVRVFTFSVGQHN---YDVTPLQWMACA 444

  Fly   510 --------PS-------GQEASELVGRFYVLSKMHAETSLPQTSSRIFGPLFQERYLSDTLEVHP 559
                    ||       .||..:::||..||:...|:                        :|..
Human   445 NKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEAK------------------------QVQW 485

  Fly   560 PVVDADSGDVLVSITHAVPPY----------------GVVGVNLYLSDLLEDLLNYPSTTSSAKQ 608
            ..|..|:..:.:.:|..:|.:                ||:|:::.|:|:.....||   |..|.
Human   486 TNVYEDALGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNY---TLGAN- 546

  Fly   609 GLGYAFLLDRSTGNTLAHPAF-PRPLIQRETSYPVNIAYL--ENATDFSSHIRDRLLREESGN-- 668
              ||.|.:|.: |..|.||.. |:....||   ||.:.:|  |...:....||..::....|:
Human   547 --GYVFAIDLN-GYVLLHPNLKPQTTNFRE---PVTLDFLDAELEDENKEEIRRSMIDGNKGHKQ 605

  Fly   669 VTTDV------YVGRQRLQRTYYWQSVLGFYVLCLVSSGGDTLRNVSSTQRYNLKDTVSNYEPGY 727
            :.|.|      |:  ..:.|.|.|..:..                             :||..|.
Human   606 IRTLVKSLDERYI--DEVTRNYTWVPIRS-----------------------------TNYSLGL 639

  Fly   728 YGESMDLLYHRLDLNQGGSAPPKTCRYFRQVATMDAPTL------FLSAAAFES-------PFGF 779
            ........|.:.:|:.             |:..:..|..      ||..::|||       |..:
Human   640 VLPPYSTFYLQANLSD-------------QILQVKLPISKLKDFEFLLPSSFESEGHVFIAPREY 691

  Fly   780 ---LHNNRPRTQ-LRHVESIMAYLRDSSG-----LLANMGLRPSIRHEVGVLYQAMQQLRRRHQD 835
               |:.:...|: |::...:|..:...|.     ||.|:.|      :.|:..|.:::: .|.||
Human   692 CKDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLIL------DTGITQQLVERV-WRDQD 749

  Fly   836 ARGSLRSH-VIRRYIASVSGVLQLYPGCLLSSSYDPTRRP------WFRQAIAQPGKIVSTAPYL 893
                |.:: ::..:.|:..|:.:::|.   .::.|.|..|      ::|:::...| .|...|:.
Human   750 ----LNTYSLLAVFAATDGGITRVFPN---KAAEDWTENPEPFNASFYRRSLDNHG-YVFKPPHQ 806

  Fly   894 DA---------GGAGYIITIAHTIFEGKAHALHSAQQDRPVAV-VALDV-PYAFYYRLILEG--- 944
            ||         ...|.:::.|..:..|:       :..||..| |.||: .:|..::::...
Human   807 DALLRPLELENDTVGILVSTAVELSLGR-------RTLRPAVVGVKLDLEAWAEKFKVLASNRTH 864

  Fly   945 ----------TPICQL------PHIKCLLFEHEGYLLAHPSMLQPATLTKNQRRPHEHL------ 987
                      ...|::      ..:.|:|.:..|:|           :..||....:.:
Human   865 QDQPQKQCGPNSHCEMDCEVNNEDLLCVLIDDGGFL-----------VLSNQNHQWDQVGRFFSE 918

  Fly   988 ---------------THKESY------------------------LANDMLN------------- 1000
                           |.||||                        ...|.||
Human   919 VDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAWSLF 983

  Fly  1001 ----HGQL-----------------VRKLGCASYQNRTLQRYY--AFNTSLSSIL--GN---VVH 1037
                :|.:                 .|:..|...|.    :||  :.|.|.::|:  ||   :.|
Human   984 QQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQT----QYYFGSVNASYNAIIDCGNCSRLFH 1044

  Fly  1038 GERTKYAIALIRGSNLFAAV----LNSSCDGGAFCPCSTIDRECLNCKRMDQTDCECPCECPMV 1097
            .:|       :..:||...|    |.|.|:.|...              ..:|..:.|.:|.:|
Human  1045 AQR-------LTNTNLLFVVAEKPLCSQCEAGRLL--------------QKETHSDGPEQCELV 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16868	NP_611469.1	vWFA	308..>426	CDD:294047	31/123 (25%)
CG16868	NP_611469.1	Cache_1	559..627	CDD:280839	19/83 (23%)
CACNA2D2	XP_011532545.1	VWA_N	141..265	CDD:285584	29/164 (18%)
		vWA_VGCC_like	277..456	CDD:238740	47/226 (21%)
		Cache_1	485..573	CDD:280839	22/94 (23%)
		VGCC_alpha2	580..663	CDD:285647	17/126 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810