Protein Alignment CG16868 and CACNA2D2

DIOPT Version :10

• Sequence 1: NP_611469.1
• Gene: CG16868 / 37298
• FlyBaseID: FBgn0034498
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: XP_011532545.1
• Gene: CACNA2D2 / 9254
• HGNCID: 1400
• Length: 1151
• Species: Homo sapiens
• Alignment Length: 1299
• Identity: 236/1299 - (18%)
• Similarity: 433/1299 - (33%)
• Gaps: 468/1299 - (36%)

  Fly    20 PTSSQHVPLAMANSTSNQVPTDPGFMPLQQSPGS---VFFVHHNQQN-AMQLRHSMEGKLRNIRN 80
            |||....||.:.      :|    .:||..:||:   .|...|..|: |.:|...::|.:|....
Human    36 PTSGPPRPLWLL------LP----LLPLLAAPGASAYSFPQQHTMQHWARRLEQEVDGVMRIFGG 90

  Fly    81 TELRVAKIQEIFDSMHFSSAKGASNTRQASSNDSNVVNPQLQRDLQLFSERLSKKIQKATYVVLE 145
                |.:::||:        |...|..:...|:...:..::..|::...:|..:.:::.......
Human    91 ----VQQLREIY--------KDNRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAEN 143

  Fly   146 LRELLRYNLTKVWQYSYDDE-----DDESESEMDLEMELEDLHARNTASPTDEHVQLYLNTQIES 205
            .::..|      ||.:..:|     |.::::|:| :.|.||:...:.||      .|.|:. ||
Human   144 FQKAHR------WQDNIKEEDIVYYDAKADAELD-DPESEDVERGSKAS------TLRLDF-IE- 193

  Fly   206 CQPDYETDLEYGSSSTQ---SIHYNRQQIQILNYLKSDDARATFLNENNARSLAVNGYISNQLVL 267
             .|:::..:.|..::.|   .|:  :....|||.|...:|......||..:...:...:......
Human   194 -DPNFKNKVNYSYAAVQIPTDIY--KGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATG 255

  Fly   268 LKRRLSRSDAENSNSKPISGNHFKHIYFLSNSDGASASLHF-----RQLYV-SAIKQKFVLFLID 326
            :.|                       |:.:....|...:..     |..|: .|...|.::.::|
Human   256 VTR-----------------------YYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVD 297

  Fly   327 VGSALSAELFDLSKSFVHEMLQLLEDTDKVSLVTVASEANFMSLEAFPAEAGHGIYSATRAHKEE 391
            |..::|.....|.|:.|.|||..|.|.|.|::.:...:|..:|......:|.   ....:..||.
Human   298 VSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQAN---VRNKKVFKEA 359

  Fly   392 IISFINSLSRAQAFTNHSLGFEYSFELLHRLQQSGMINTAEQPVEFVYITRGLLTNLSDAMAVLR 456
            :...:     |:..|.:..||||:|:   :||.|.             |||      ::...::.
Human   360 VQGMV-----AKGTTGYKAGFEYAFD---QLQNSN-------------ITR------ANCNKMIM 397

  Fly   457 VVADGQRRLRAPVIINTCAVVLDEKRIMYEKQ---------FLNDVASQNYTKYEIDVASWW--- 509
            :..||..               |..:.::||.         |...|...|   |::....|.
Human   398 MFTDGGE---------------DRVQDVFEKYNWPNRTVRVFTFSVGQHN---YDVTPLQWMACA 444

  Fly   510 --------PS-------GQEASELVGRFYVLSKMHAETSLPQTSSRIFGPLFQERYLSDTLEVHP 559
                    ||       .||..:::||..||:...|:                        :|..
Human   445 NKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEAK------------------------QVQW 485

  Fly   560 PVVDADSGDVLVSITHAVPPY----------------GVVGVNLYLSDLLEDLLNYPSTTSSAKQ 608
            ..|..|:..:.:.:|..:|.:                ||:|:::.|:|:.....||   |..|.
Human   486 TNVYEDALGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNY---TLGAN- 546

  Fly   609 GLGYAFLLDRSTGNTLAHPAF-PRPLIQRETSYPVNIAYL--ENATDFSSHIRDRLLREESGN-- 668
              ||.|.:|.: |..|.||.. |:....||   ||.:.:|  |...:....||..::....|:
Human   547 --GYVFAIDLN-GYVLLHPNLKPQTTNFRE---PVTLDFLDAELEDENKEEIRRSMIDGNKGHKQ 605

  Fly   669 VTTDV------YVGRQRLQRTYYWQSVLGFYVLCLVSSGGDTLRNVSSTQRYNLKDTVSNYEPGY 727
            :.|.|      |:  ..:.|.|.|..:..                             :||..|.
Human   606 IRTLVKSLDERYI--DEVTRNYTWVPIRS-----------------------------TNYSLGL 639

  Fly   728 YGESMDLLYHRLDLNQGGSAPPKTCRYFRQVATMDAPTL------FLSAAAFES-------PFGF 779
            ........|.:.:|:.             |:..:..|..      ||..::|||       |..:
Human   640 VLPPYSTFYLQANLSD-------------QILQVKLPISKLKDFEFLLPSSFESEGHVFIAPREY 691

  Fly   780 ---LHNNRPRTQ-LRHVESIMAYLRDSSG-----LLANMGLRPSIRHEVGVLYQAMQQLRRRHQD 835
               |:.:...|: |::...:|..:...|.     ||.|:.|      :.|:..|.:::: .|.||
Human   692 CKDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLIL------DTGITQQLVERV-WRDQD 749

  Fly   836 ARGSLRSH-VIRRYIASVSGVLQLYPGCLLSSSYDPTRRP------WFRQAIAQPGKIVSTAPYL 893
                |.:: ::..:.|:..|:.:::|.   .::.|.|..|      ::|:::...| .|...|:.
Human   750 ----LNTYSLLAVFAATDGGITRVFPN---KAAEDWTENPEPFNASFYRRSLDNHG-YVFKPPHQ 806

  Fly   894 DA---------GGAGYIITIAHTIFEGKAHALHSAQQDRPVAV-VALDV-PYAFYYRLILEG--- 944
            ||         ...|.:::.|..:..|:       :..||..| |.||: .:|..::::...
Human   807 DALLRPLELENDTVGILVSTAVELSLGR-------RTLRPAVVGVKLDLEAWAEKFKVLASNRTH 864

  Fly   945 ----------TPICQL------PHIKCLLFEHEGYLLAHPSMLQPATLTKNQRRPHEHL------ 987
                      ...|::      ..:.|:|.:..|:|           :..||....:.:
Human   865 QDQPQKQCGPNSHCEMDCEVNNEDLLCVLIDDGGFL-----------VLSNQNHQWDQVGRFFSE 918

  Fly   988 ---------------THKESY------------------------LANDMLN------------- 1000
                           |.||||                        ...|.||
Human   919 VDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAWSLF 983

  Fly  1001 ----HGQL-----------------VRKLGCASYQNRTLQRYY--AFNTSLSSIL--GN---VVH 1037
                :|.:                 .|:..|...|.    :||  :.|.|.::|:  ||   :.|
Human   984 QQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQT----QYYFGSVNASYNAIIDCGNCSRLFH 1044

  Fly  1038 GERTKYAIALIRGSNLFAAV----LNSSCDGGAFCPCSTIDRECLNCKRMDQTDCECPCECPMV 1097
            .:|       :..:||...|    |.|.|:.|...              ..:|..:.|.:|.:|
Human  1045 AQR-------LTNTNLLFVVAEKPLCSQCEAGRLL--------------QKETHSDGPEQCELV 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16868	NP_611469.1	vWFA	308..>426	CDD:469594	31/123 (25%)
		HK_sensor	<867..933	CDD:365792	18/82 (22%)
CACNA2D2	XP_011532545.1	VWA_N	141..265	CDD:462464	29/164 (18%)
		vWA_VGCC_like	277..456	CDD:238740	47/226 (21%)
		HK_sensor	<448..531	CDD:365792	17/106 (16%)
		HK_sensor	533..642	CDD:365792	32/149 (21%)
		VGCC_alpha2	669..1112	CDD:462488	82/477 (17%)