Protein Alignment CG16868 and cachd1

DIOPT Version :9

• Sequence 1: NP_611469.1
• Gene: CG16868 / 37298
• FlyBaseID: FBgn0034498
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: XP_001334829.3
• Gene: cachd1 / 794807
• ZFINID: ZDB-GENE-100819-3
• Length: 1290
• Species: Danio rerio
• Alignment Length: 1460
• Identity: 416/1460 - (28%)
• Similarity: 656/1460 - (44%)
• Gaps: 331/1460 - (22%)

  Fly    74 KLRNIRNTELRVAKIQEIFDSMHFSSAKGASNTRQASSNDSNVVNPQLQRDLQLFSERLSKKIQK 138
            :::.:...||.|..:|.||:|..:        |.:.|:.::.|             ::|:|||::
Zfish    64 QMKKLSTQELGVLTMQRIFNSFVY--------TEKTSNGETEV-------------QQLAKKIRE 107

  Fly   139 ATYVVLELRELLRYNLTKVWQYSYDDEDDESESEMDLEMELEDLHARNTASPTDEHVQLYLNTQI 203
                        ::|       .|.|..:.:      :..:|..:..:..||.         |.|
Zfish   108 ------------KFN-------RYLDVVNRN------KQVVEASYTAHLTSPL---------TAI 138

  Fly   204 ESC---QPD-YETDLEYGSSSTQSIHYNRQQIQILNYLKSDDARATFLNENNARSLAVNGYISNQ 264
            :.|   .|. .|.|..:.::.::::..:|                        .|..||....|.
Zfish   139 QDCCSIPPSMMEFDGNFNANVSKTVSCDR------------------------LSPTVNSRAFNP 179

  Fly   265 LVLLKRRLSRSDAENSNSKPISGNHFKHIYFLSNSDG-----ASASLH--------FRQLYVSAI 316
                .|.|:...|:|..|.|    ..|..|| |:.:|     .:...|        .|.:||:|:
Zfish   180 ----GRDLNSVLADNLKSNP----GIKWQYF-SSEEGIFTLFPAHKFHCKGTFEHRSRPVYVAAV 235

  Fly   317 K--QKFVLFLIDVGSALSAELFDLSKSFVHEMLQLLEDTDKVSLVTVASEANFMSLE----AFPA 375
            :  .|.::.:||.|::::.....:::.....:|..:::.||:|::|:|......||:    :|
Zfish   236 RPQSKHIVVIIDHGASVTETQLQIARDAALVILNSIDEHDKISVLTIADTVRSCSLDQCYKSF-- 298

  Fly   376 EAGHGIYSATRAHKEEIISFINSLSRAQAFTNHSLGFEYSFELLHRLQQSGMINTAEQ----PVE 436
                 :..||...|.::.:||:::..:.:.|.|::||:.:|:||....     |...|    .:.
Zfish   299 -----LSPATSETKRKMSTFISNIKASDSSTQHAVGFQKAFQLLRNTS-----NVTRQLTNTDMM 353

  Fly   437 FVYITRGLLTNLS---DAMAVLRVVADGQRRLRAPVIINTCAVVLDEKRIMYEKQFLNDVASQNY 498
            .:|::.|:.:..|   :..|.|..|.:..|.|...|:|.|.|::.|....:.|..||.|:|.||.
Zfish   354 IIYLSSGITSRDSSEHEKRATLSAVKEENRHLNNSVMILTYALMNDGVTGLKELAFLRDLAEQNS 418

  Fly   499 TKYEIDVASWWP------------SGQEASELVGRFYVLSKMHAETSLPQTSSRIFGPLFQERYL 551
            .||.:...|..|            |..|.:  |||||:        :||..             :
Zfish   419 LKYGVQDRSALPVVKGSMMVLNQLSNLETT--VGRFYI--------NLPNR-------------M 460

  Fly   552 SDTLEVHPPVVDADSGDVLVSITHAVPPY------GVVGVNLYLSDLLEDLLNYPSTTSSAKQGL 610
            .|......|..| ..||..: :|.:.|.|      |||||::.|:.:|||:..|..:.:|
Zfish   461 IDVATFSLPYAD-QMGDGFI-MTVSRPCYFGNLLLGVVGVDVNLAYILEDVTYYQDSLAS----- 518

  Fly   611 GYAFLLDRSTGNTLAHPAFPRPLIQRETSYPVNIAYLENATDFSSHIRDRLLREESGNVTTDVYV 675
             |.||:| :.|.||.||:..||.:..|.....:|.:.||...|.. :|..:|....|:....|.|
Zfish   519 -YTFLID-NKGYTLMHPSLTRPYLMTEAPLHTDIIHYENIPGFPV-VRQNILSLPLGSQVIAVPV 580

  Fly   676 --------------GRQRLQRTYYWQSVLG-FYVLCLVSSGGDTLRNVSSTQRYNLKDTVSNYEP 725
                          .|.....:|.|:.|.. .::||:|.    ....:...|..||     |..|
Zfish   581 NSSLSWHMNRLRDPNRDAYNVSYAWKLVQDTSFILCIVY----VQPEIPVKQLKNL-----NTAP 636

  Fly   726 GYYGESMDLLYHRLDLNQGGSAPPKTCRYFRQVATMDAPTLFLSAAAFESPFGFLHNNRPRTQLR 790
                 |..||||||||    ...|.:|.:|:|:||:::||:.|||.:|.||:.  |.::|.|: |
Zfish   637 -----SSKLLYHRLDL----LGQPSSCLHFKQLATVESPTVMLSAGSFSSPYE--HLSQPETK-R 689

  Fly   791 HVESIMAYLRDSSGLLANMGLRPSIRHEVGVL------YQAMQQLRRRHQDARGSLRSHVIRRYI 849
            .||...|||.|::.|:||.||:.|:|:||...      :.::.::        .||..:::||||
Zfish   690 MVEHYTAYLSDNTRLIANPGLKSSVRNEVMATSHVTDEWMSLMEM--------SSLNCYIVRRYI 746

  Fly   850 ASVSGVLQLYPGCLLSSSYDPTRRPWFRQAIAQPGKIVSTAPYLDAGGAGYIITIAHTIFEGKAH 914
            |:.:|||::|||.|:..::|||||.|:..|:|.||.|..|.||||.|||||::||:|||     |
Zfish   747 ATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLITFTGPYLDVGGAGYVVTISHTI-----H 806

  Fly   915 ALHSAQ-QDRPVAVVALDVPYAFYYRLILEGTPICQLP---HIKCLLFEHEGYLLAHPSMLQPAT 975
            |..|.. ....|||:.:|....::|:::|:..|||...   .|:|.:.|..|||:|||:::.|..
Zfish   807 APSSQMASGYTVAVMGIDFTLRYFYKVLLDLLPICNQDKGNKIRCFIMEDRGYLVAHPTLIDPKG 871

  Fly   976 LTKNQRRPHEHLTHKESYLANDMLNHGQLVRKLGCASYQNRTLQRYYAFNTSLSSILGNVVHGER 1040
            ....::   :|:||||..:|||:|||...|:|..|.|:.:||:||:|.||||:...|.|:|||..
Zfish   872 HAPAEQ---QHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQRFYKFNTSIVGDLTNLVHGSH 933

  Fly  1041 -TKYAIALIRGSNLFAAVLNSSCDGGAFCPCSTIDRECLNCKRMDQTDCECPCECPMVGDSSSPS 1104
             :||.:..|.|:|.||.::|.:||..|||.|||:||.||||.||:|.:||||||||:..:..:.:
Zfish   934 CSKYRLTRIPGTNAFAGIVNETCDALAFCACSTVDRLCLNCHRMEQNECECPCECPLEVNECTGN 998

  Fly  1105 SLMYFANYTRQFPYCPPPSE--HFIALPPTTQLLSTLPNCPGSAGICETYSTQRECLGVMGCEWC 1167
                ..|...:.|.|....|  ....:.|:.|  .|||.|..:.  |....|..:|.||:.||||
Zfish   999 ----LTNAENRNPSCDVHQEPLSLTVIEPSLQ--DTLPQCINTR--CSQRFTSSDCFGVLDCEWC 1055

  Fly  1168 QLDVDGNS-FSTSFCSSQASCFNGVLASLTPY----GELDEMELLAAHNPQREQHAYSAFGPLGG 1227
            .:|.||.: ....:|:.|..||.|::.:.:||    |.|||.  ||:.|..:.    :..||:.|
Zfish  1056 MVDSDGKTHLDKPYCALQKECFGGIVGAKSPYVDGMGILDEE--LASLNMIKS----APVGPVAG 1114

  Fly  1228 AIVVLVMVIGFAIYCYRHNLDAQTQEHFYVDSVQEENYGLPLSRFNFDDCKAHDEPPLGGGYDHA 1292
            .|:..:||:..|:|.|||.:..::.:|....:.||    :.:...|.|:  ..|:.......|..
Zfish  1115 GIMGCIMVLVLAVYAYRHQIHRRSHQHMSPLAAQE----MSVRMSNLDN--ERDDRDEDSHEDRG 1173

  Fly  1293 SAQRQLMHAADISPYHVSSGSSYRR---PPNGESDHGYSTMTPHEDSSDQQCFTLAEPLLLHDKR 1354
            ........||.|. .|..|....||   ....|||||||||:|.|||.:..|
Zfish  1174 IISNTRFIAAVIE-RHTHSPERRRRYWGRSGTESDHGYSTMSPQEDSENPPC------------- 1224

  Fly  1355 HSKSDTMSISTSISSPTNRQQSSSQPNT--------HPYLSNQPTSKTERYKQVQATPSPCRGTP 1411
              .:|.:|....:.:........:.|.|        |||          |:..:..
Zfish  1225 --NNDPLSAGVDVGNHDEDLDLDTPPQTAALLSHKFHPY----------RHPHMHH--------- 1268

  Fly  1412 AGGSVYGQTTLPLEGDKTRPHYILAPVTVH 1441
                       ||.   ...|::.|.||||
Zfish  1269 -----------PLH---LHTHHLQAAVTVH 1284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16868	NP_611469.1	vWFA	308..>426	CDD:294047	29/123 (24%)
		Cache_1	559..627	CDD:280839	25/73 (34%)
cachd1	XP_001334829.3	VWA_N	102..217	CDD:285584	31/181 (17%)
		vWFA	226..>355	CDD:294047	31/140 (22%)
		Cache_1	469..536	CDD:280839	27/75 (36%)
		Cache_1	785..866	CDD:280839	36/85 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580324
Domainoid	1	1.000	448	1.000	Domainoid score	I496
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10854
Inparanoid	1	1.050	500	1.000	Inparanoid score	I1333
OMA	1	1.010	-	-		QHG50145
OrthoDB	1	1.010	-	-		D137593at33208
OrthoFinder	1	1.000	-	-		FOG0006978
OrthoInspector	1	1.000	-	-		otm25430
orthoMCL	1	0.900	-	-		OOG6_109476
Panther	1	1.100	-	-	LDO	PTHR10166
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4494
SonicParanoid	1	1.000	-	-		X5065
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800