DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG16868 and CACHD1

DIOPT Version :9

Sequence 1:NP_611469.1 Gene:CG16868 / 37298 FlyBaseID:FBgn0034498 Length:1449 Species:Drosophila melanogaster
Sequence 2:NP_065976.3 Gene:CACHD1 / 57685 HGNCID:29314 Length:1274 Species:Homo sapiens


Alignment Length:1417 Identity:405/1417 - (28%)
Similarity:655/1417 - (46%) Gaps:282/1417 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 MEGKLRNIRNTELRVAKIQEIFDSMHFSSAKGASNTRQASSNDSNVVNPQLQRDLQLFSERLSKK 135
            :..::|.:...||.|..:|.||:|..:        |.:.|:.:|.|             ::|:||
Human    48 LASQMRRLAAEELGVVTMQRIFNSFVY--------TEKISNGESEV-------------QQLAKK 91

  Fly   136 IQKATYVVLELRELLRYNLTKVWQYSYDDEDDESESEMDLEMELEDLHARNTASPTDEHVQLYLN 200
            |::            ::|       .|.|..:.:      :..:|..:..:..||.         
Human    92 IRE------------KFN-------RYLDVVNRN------KQVVEASYTAHLTSPL--------- 122

  Fly   201 TQIESC---QPD-YETDLEYGSSSTQSIHYNRQQIQILNYLKSDDARATFLNE---NNARSLAVN 258
            |.|:.|   .|. .|.|..:.::.:::|              |.|..:|.:|.   |..|.|   
Human   123 TAIQDCCTIPPSMMEFDGNFNTNVSRTI--------------SCDRLSTTVNSRAFNPGRDL--- 170

  Fly   259 GYISNQLVLLKRRLSRSDAENSNSKPISGNHFKHIYFLSNSDG-------------ASASLHFRQ 310
                |.::          |:|..|.|    ..|..|| |:.:|             .|.....|.
Human   171 ----NSVL----------ADNLKSNP----GIKWQYF-SSEEGIFTVFPAHKFRCKGSYEHRSRP 216

  Fly   311 LYVSAIK--QKFVLFLIDVGSALSAELFDLSKSFVHEMLQLLEDTDKVSLVTVASEANFMSLE-- 371
            :|||.::  .|.::.::|.|::::.....::|.....:|..:::.||:|::|||......||:  
Human   217 IYVSTVRPQSKHIVVILDHGASVTDTQLQIAKDAAQVILSAIDEHDKISVLTVADTVRTCSLDQC 281

  Fly   372 --AFPAEAGHGIYSATRAHKEEIISFINSLSRAQAFTNHSLGFEYSFELLHRLQQSGMINT---A 431
              .|       :..||...|.::.:|::|:..:.:.|.|::||:.:|:|:    :|...||   |
Human   282 YKTF-------LSPATSETKRKMSTFVSSVKSSDSPTQHAVGFQKAFQLI----RSTNNNTKFQA 335

  Fly   432 EQPVEFVYITRGLLTNLS---DAMAVLRVVADGQRRLRAPVIINTCAVVLDEKRIMYEKQFLNDV 493
            ...:..:|::.|:.:..|   |..|.|:|:.:....|...|:|.|.|::.|....:.|..||.|:
Human   336 NTDMVIIYLSAGITSKDSSEEDKKATLQVINEENSFLNNSVMILTYALMNDGVTGLKELAFLRDL 400

  Fly   494 ASQNYTKYEIDVASWWPSGQEASELVGRFYVLSKMHAETSLPQTSSRIFGPLFQERYLSDTLEVH 558
            |.||..||.:      |.......:.|...||:::   ::|..|..|.:..| ..|.:.:.:...
Human   401 AEQNSGKYGV------PDRMALPVIKGSMMVLNQL---SNLETTVGRFYTNL-PNRMIDEAVFSL 455

  Fly   559 PPVVDADSGDVLVSITHAVPPY------GVVGVNLYLSDLLEDLLNYPSTTSSAKQGLGYAFLLD 617
            |  ...:.||.|: :|.:.|.|      |:|||::.|:.:|||:..|..:.:|      |.||:|
Human   456 P--FSDEMGDGLI-MTVSKPCYFGNLLLGIVGVDVNLAYILEDVTYYQDSLAS------YTFLID 511

  Fly   618 RSTGNTLAHPAFPRPLIQRETSYPVNIAYLENATDFSSHIRDRLLREESGNVTTDVYV------- 675
             ..|.||.||:..||.:..|.....:|.:.||...|.. :|..:|....|:....|.|       
Human   512 -DKGYTLMHPSLTRPYLLSEPPLHTDIIHYENIPKFEL-VRQNILSLPLGSQIIAVPVNSSLSWH 574

  Fly   676 -------GRQRLQRTYYWQSVLG-FYVLCLVSSGGDTLRNVSSTQRYNLKDTVSNYEPGYYGESM 732
                   |::....:|.|:.|.. .::||:|....:    :...|..|| :||         .|.
Human   575 INKLRETGKEAYNVSYAWKMVQDTSFILCIVVIQPE----IPVKQLKNL-NTV---------PSS 625

  Fly   733 DLLYHRLDLNQGGSAPPKTCRYFRQVATMDAPTLFLSAAAFESPFGFLHNNRPRTQLRHVESIMA 797
            .||||||||    ...|..|.:|:|:||:::||:.|||.:|.||:.  |.::|.|: |.||...|
Human   626 KLLYHRLDL----LGQPSACLHFKQLATLESPTIMLSAGSFSSPYE--HLSQPETK-RMVEHYTA 683

  Fly   798 YLRDSSGLLANMGLRPSIRHEV----GVLYQAMQQLRRRHQDARGSLRSHVIRRYIASVSGVLQL 858
            ||.|::.|:||.||:.|:|:||    .|..:.|.|:.      ..||.::::|||||:.:|||::
Human   684 YLSDNTRLIANPGLKFSVRNEVMATSHVTDEWMTQME------MSSLNTYIVRRYIATPNGVLRI 742

  Fly   859 YPGCLLSSSYDPTRRPWFRQAIAQPGKIVSTAPYLDAGGAGYIITIAHTIFEGKAHALHSA---- 919
            |||.|:..::|||||.|:..|:|.||.|..|.||||.|||||::||:|||        ||:    
Human   743 YPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDVGGAGYVVTISHTI--------HSSSTQL 799

  Fly   920 QQDRPVAVVALDVPYAFYYRLILEGTPICQLP---HIKCLLFEHEGYLLAHPSMLQPATLTKNQR 981
            .....|||:.:|....::|:::::..|:|...   .|:|.:.|..|||:|||:::.|        
Human   800 SSGHTVAVMGIDFTLRYFYKVLMDLLPVCNQDGGNKIRCFIMEDRGYLVAHPTLIDP-------- 856

  Fly   982 RPH-----EHLTHKESYLANDMLNHGQLVRKLGCASYQNRTLQRYYAFNTSLSSILGNVVHGER- 1040
            :.|     :|:||||..:|||:|||...|:|..|.|:.:||:||:|.|||||:..|.|:|||.. 
Human   857 KGHAPVEQQHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQRFYKFNTSLAGDLTNLVHGSHC 921

  Fly  1041 TKYAIALIRGSNLFAAVLNSSCDGGAFCPCSTIDRECLNCKRMDQTDCECPCECPMVGDSSSPSS 1105
            :||.:|.|.|:|.|..::|.:||..|||.||.:||.||||.||:|.:||||||||:..:..:.: 
Human   922 SKYRLARIPGTNAFVGIVNETCDSLAFCACSMVDRLCLNCHRMEQNECECPCECPLEVNECTGN- 985

  Fly  1106 LMYFANYTRQFPYCPPPSE--HFIALPPTTQLLSTLPNCPGSAGICETYSTQRECLGVMGCEWCQ 1168
               ..|...:.|.|....|  .:.|:.|..|  ..|..|..|.  |.......:|.||:.||||.
Human   986 ---LTNAENRNPSCEVHQEPVTYTAIDPGLQ--DALHQCVNSR--CSQRLESGDCFGVLDCEWCM 1043

  Fly  1169 LDVDGNS-FSTSFCSSQASCFNGVLASLTPYGELDEMELLAAHNPQREQHAYSAFGPLGGAIVVL 1232
            :|.||.: ....:|:.|..||.|::.:.:||  :|:|..:............:..||:.|.|:..
Human  1044 VDSDGKTHLDKPYCAPQKECFGGIVGAKSPY--VDDMGAIGDEVITLNMIKSAPVGPVAGGIMGC 1106

  Fly  1233 VMVIGFAIYCYRHNLDAQTQEHFYVDSVQEENYGLPLSRFNFDDCKAHDEPPLGGGYDHASAQRQ 1297
            :||:..|:|.|||.:..::.:|....:.||  ..:.:|....|..:..|:     .::.......
Human  1107 IMVLVLAVYAYRHQIHRRSHQHMSPLAAQE--MSVRMSNLENDRDERDDD-----SHEDRGIISN 1164

  Fly  1298 LMHAADISPYHVSSGSSYRR---PPNGESDHGYSTMTPHEDSSDQQCFTLAEPLLLHDKRHSKSD 1359
            ....|.:...|..|....||   ....|||||||||:|.|||.:..|               .:|
Human  1165 TRFIAAVIERHAHSPERRRRYWGRSGTESDHGYSTMSPQEDSENPPC---------------NND 1214

  Fly  1360 TMSISTSISSPTNRQQSSSQPNT--------HPYLSNQPTSKTERYKQVQAT 1403
            .:|....:.:........:.|.|        |.|.|:.||.....:.|...|
Human  1215 PLSAGVDVGNHDEDLDLDTPPQTAALLSHKFHHYRSHHPTLHHSHHLQAAVT 1266

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG16868NP_611469.1 vWFA 308..>426 CDD:294047 29/123 (24%)
Cache_1 559..627 CDD:280839 24/73 (33%)
CACHD1NP_065976.3 VWA_N 95..204 CDD:312040 30/166 (18%)
vWFA 213..408 CDD:320736 53/205 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1179..1227 18/62 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146872
Domainoid 1 1.000 445 1.000 Domainoid score I530
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H10854
Inparanoid 1 1.050 498 1.000 Inparanoid score I1387
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG50145
OrthoDB 1 1.010 - - D137593at33208
OrthoFinder 1 1.000 - - FOG0006978
OrthoInspector 1 1.000 - - oto88632
orthoMCL 1 0.900 - - OOG6_109476
Panther 1 1.100 - - LDO PTHR10166
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4494
SonicParanoid 1 1.000 - - X5065
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.940

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