Protein Alignment CG16868 and CACNA2D3

DIOPT Version :9

• Sequence 1: NP_611469.1
• Gene: CG16868 / 37298
• FlyBaseID: FBgn0034498
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: NP_060868.2
• Gene: CACNA2D3 / 55799
• HGNCID: 15460
• Length: 1091
• Species: Homo sapiens
• Alignment Length: 1136
• Identity: 211/1136 - (18%)
• Similarity: 398/1136 - (35%)
• Gaps: 354/1136 - (31%)

  Fly   151 RYNLTKVWQYSYDD-EDDESESEMD-------LEMELEDL-HARNTASPTDEHVQLYLNTQIESC 206
            :|:.:::.|..|.: |.|.:..|:|       |...:|:: |.::.|          :...:|:.
Human    59 KYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEA----------VRRLVEAA 113

  Fly   207 QP-----DYETDLEYGSSSTQSIHYNRQQIQILNYLKSDDARATFLNENNARSLAVNGYISNQLV 266
            :.     :::.||:|.       ::|...|      ...|....||.......||.|.:.:|
Human   114 EEAHLKHEFDADLQYE-------YFNAVLI------NERDKDGNFLELGKEFILAPNDHFNN--- 162

  Fly   267 LLKRRLSRSDAE------NSNSKPISGNHFK---HIYFLSNSDG---------ASASLHFRQL-- 311
             |...:|.||.:      |.:...::|.::.   :..|:.|.|.         .||...|||.
Human   163 -LPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPG 226

  Fly   312 --------------------YV-SAIKQKFVLFLIDVGSALSAELFDLSKSFVHEMLQLLEDTDK 355
                                |: :|...|.|:.|:||..::......::|..|..:|..|.|.|.
Human   227 IKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDF 291

  Fly   356 VSLVTVASEANFMSLEAFPAEAGHGIYSATRAHKEEIISFINSLSRAQAFTNHSLGFEYSFELLH 420
            .:::....|.:::.    |...| .:..|.|.:||.....::.|. |:......:....:|.:|.
Human   292 FNIIAYNEELHYVE----PCLNG-TLVQADRTNKEHFREHLDKLF-AKGIGMLDIALNEAFNILS 350

  Fly   421 RLQQSGMINTAEQPVEFVYITRGLLTNLSDAMAVLRVVADGQRRLRA-PVIINTCAVVLDEKRIM 484
            ....:|..:...|.:  :.||.|.:.......|....   ..|::|. ..:|...|...|..:.|
Human   351 DFNHTGQGSICSQAI--MLITDGAVDTYDTIFAKYNW---PDRKVRIFTYLIGREAAFADNLKWM 410

  Fly   485 --YEKQFLNDVAS-----QNYTKYEIDVASWWPSGQEASELVGRFYVLSKMHAETSLPQTSSRIF 542
              ..|.|...:::     :|..:|                    .:|||:       |:...:..
Human   411 ACANKGFFTQISTLADVQENVMEY--------------------LHVLSR-------PKVIDQEH 448

  Fly   543 GPLFQERYLSDTLEVHPPVVDADSGDVLVSITHAVPPY-------------GVVGVNLYLSDLLE 594
            ..::.|.|:..||.....:.| |.|.||:: |.|:|.:             ||||.::.:.:||:
Human   449 DVVWTEAYIDSTLPQAQKLTD-DQGPVLMT-TVAMPVFSKQNETRSKGILLGVVGTDVPVKELLK 511

  Fly   595 DLLNYPSTTSSAKQGL-GYAFLLDRSTGNTLAHPAFPRPLIQ-----RETSY-PVNIAYLENATD 652
            .:..|       |.|: ||||.: .:.|..|.||.. |.|.:     |:.:| .|:::.:| ..|
Human   512 TIPKY-------KLGIHGYAFAI-TNNGYILTHPEL-RLLYEEGKKRRKPNYSSVDLSEVE-WED 566

  Fly   653 FSSHIRDRLLREESGNVTTDVY----VGRQRLQRT--YYWQSVLG--FYVLCLVSSGGDTLRNVS 709
            ....:|:.::..::|..:.:|.    .|::.|..|  ||:..:.|  |.:...:|.|..
Human   567 RDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVALSRGHG------ 625

  Fly   710 STQRYNLKDTVSNYEPGYYGESMDL------LYHRLDLNQGGSAPPKTCRYFRQVATMDAPTLFL 768
               :|..:..|:..|..:..|..|:      .|...||:      |:    .|.::.::|..|:|
Human   626 ---KYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLH------PE----HRHLSQLEAIKLYL 677

  Fly   769 S----------------------AAAFESPFGFLHNNRPRTQLRHVESIMAYLRDSSGLLANMGL 811
            .                      :|..|:.:..|..|:.....:.||  :|:|...:||
Human   678 KGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVE--VAFLGTRTGL------ 734

  Fly   812 RPSIRHEVGVLYQAMQQLRRRHQDARGSLRSHVIRRYIASVSGVLQLYPGCLLSSSYDPTRRPWF 876
                 ..:. |:...:||..:.....|...:                    :.::.:.|.   |:
Human   735 -----SRIN-LFVGAEQLTNQDFLKAGDKEN--------------------IFNADHFPL---WY 770

  Fly   877 RQAIAQ-PGKIVSTAPYLDAG--GAGYIITIAHTIFEGKAHALHSAQQDRPVAVVALDVPYAFYY 938
            |:|..| ||..|.:.|: ..|  ....::|.:.:|      .|...::...||.|.:.:...|:.
Human   771 RRAAEQIPGSFVYSIPF-STGPVNKSNVVTASTSI------QLLDERKSPVVAAVGIQMKLEFFQ 828

  Fly   939 RLI---------LEG--TPICQLPHIKCLLFEHEGYLLAHPSMLQPATLTKNQRRPHEHLTHKES 992
            |..         |:|  :..|....:.|.|.::.|::|          ::::..:..:.....|.
Human   829 RKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFIL----------VSEDYTQTGDFFGEIEG 883

  Fly   993 YLANDMLNHGQLVRKLGCASYQ-------------NRTLQRYYAFNTSLSSILGNVV-------- 1036
            .:.|.:|..|.. :::....||             :..|..|.||.:::..|:..:|
Human   884 AVMNKLLTMGSF-KRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNL 947

  Fly  1037 ----HGERT----------------------------------------KYAIALIRGSNLFAAV 1057
                |.:.|                                        .:.|..|..||||..|
Human   948 CSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVV 1012

  Fly  1058 LNSSCDGGAFCPCSTID-----RECLNCKRM 1083
            ::|||...:..|.:...     .|.|.|:|:
Human  1013 VDSSCLCESVAPITMAPIEIRYNESLKCERL 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16868	NP_611469.1	vWFA	308..>426	CDD:294047	27/140 (19%)
		Cache_1	559..627	CDD:280839	23/81 (28%)
CACNA2D3	NP_060868.2	VWA_N	113..229	CDD:369855	26/132 (20%)
		vWA_VGCC_like	242..425	CDD:238740	38/193 (20%)
		MIDAS-like motif	262..266		2/3 (67%)
		dCache_1	<442..552	CDD:376917	32/120 (27%)
		PDC2_MCP_like	508..622	CDD:350337	30/123 (24%)
		VGCC_alpha2	655..1068	CDD:369894	76/454 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810