Protein Alignment CG16868 and cacna2d2a

DIOPT Version :10

• Sequence 1: NP_611469.1
• Gene: CG16868 / 37298
• FlyBaseID: FBgn0034498
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: NP_001013521.4
• Gene: cacna2d2a / 541376
• ZFINID: ZDB-GENE-050320-71
• Length: 1109
• Species: Danio rerio
• Alignment Length: 1051
• Identity: 192/1051 - (18%)
• Similarity: 354/1051 - (33%)
• Gaps: 340/1051 - (32%)

  Fly    50 SPGSVFFVHHNQQNAMQLRHSMEGKLRNIRNTELRVAKIQEIFDSMHFSSAKGASNTRQASSNDS 114
            |||:...:.......|.....:|.:|..:........:::.|::...        |......|..
Zfish    26 SPGTATLLFPQHYTMMHWAGRIEKELEKVLQLVTGGQQMRAIYNDKR--------NQFDVVRNTP 82

  Fly   115 NVVNPQLQRDLQLFSERLSKKIQKATYVVLELRELLRYNLTKVWQYS--------YDD------- 164
            ..:..::..|:.....|..|.:::   :..|..::.|.:   .||.:        ||.
Zfish    83 KQLVEKVAGDIAKLLNRKRKALER---LAREAEDIQREH---SWQDAIKENDIQYYDAKADSDVM 141

  Fly   165 EDDESESEMD----LEMELEDLHARNTASPTDEHVQLYLNTQIESCQPDYETDLEYGSSSTQSIH 225
            :||:.|:.:|    |.:|..|                         .|:::..:.|.
Zfish   142 DDDDGENLLDNPNSLSLEFVD-------------------------DPNFKNKVNYS-------- 173

  Fly   226 YNRQQIQILNYLKSDDARATFLNENNARSLAVNGYISNQLVLLKRRLSRSDAENSNSKP-----I 285
            |...||....|..|    .|.|||.|                ..:.|.|...|||...|     :
Zfish   174 YTAVQIPTDIYKGS----PTILNELN----------------WTQSLERVFIENSREDPSLRWQV 218

  Fly   286 SGN------HFKHIYFLSNSDGASASLHFRQLYV-SAIKQKFVLFLIDVGSALSAELFDLSKSFV 343
            .|:      ::....:.:.:......:..|..|: .|...|.::.::||..::|.....|.|:.|
Zfish   219 FGSTTGVTRYYPATKWKAPNKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSV 283

  Fly   344 HEMLQLLEDTDKVSLV-------------TVASEANFMSLEAFPAEAGHGIYSATRAHKEEIISF 395
            .|||..|.|.|.|::.             |...:||..:.:.|               ||.:::.
Zfish   284 IEMLDTLSDDDYVNVARFNEKAYAVVPCFTTLVQANIKNKKIF---------------KEAVMNM 333

  Fly   396 INSLSRAQAFTNHSLGFEYSFELLHRLQQSGMINTAEQPVEFVYITRGLLTNLSDAMAVLRVVAD 460
                 :|:..|::..||:::|:.|        :|....|             .::...::.:..|
Zfish   334 -----QAKGTTDYKTGFQFAFDQL--------LNDTSAP-------------RANCNKMIMMFTD 372

  Fly   461 GQRRLRAPVIINTCAVVLDEKRIMYEKQ---------FLNDVASQNYTKYEIDVASW-------- 508
            |..               |..:.::||.         |...|...|   |::....|
Zfish   373 GGE---------------DRAQDIFEKYNWPNRTVRVFTFSVGQHN---YDVTPLQWIACFNKGY 419

  Fly   509 ---WPS-------GQEASELVGRFYVLSKMHAE----TSLPQTSSRIFGPLFQERYLSDTLEVHP 559
               .||       .||..:::||..||:...|:    |::.|.:      |.....::.|:.|..
Zfish   420 YFEIPSIGAIRINTQEYLDVLGRPMVLAGERAKQVQWTNVYQDA------LGLGLVITGTMPVFN 478

  Fly   560 PVVDADSGDVLVSITHAVPPYGVVGVNLYLSDLLEDLLNYPSTTSSAKQGL-GYAFLLDRSTGNT 623
            ...|.|:....:.:       ||:||::.|:::.|       .|...|.|. ||.|.:| ..|..
Zfish   479 LTADRDTKQNQLML-------GVMGVDIALNEIKE-------LTPRYKLGANGYTFAID-PNGYV 528

  Fly   624 LAHPAF-PRPLIQRETSYPVNIAYLENATDFSSHIRDRLLREESGNVTTDVYVGRQRL------- 680
            |.||.. |:.:..||   ||.:.:|:      :.:.|| .:||......|...|::::
Zfish   529 LLHPNLQPKIINFRE---PVTLDFLD------AELPDR-NKEEIRRQMIDGRGGQRKIKTLVKSV 583

  Fly   681 --------QRTYYWQSVLGF-YVLCLVSSGGDTLRNVSSTQ-RYNLKDTVSNYEPGYYGESMDLL 735
                    ||||.|..|.|. |.|.||      |.:.|... |.||.|.:...:.|...:..:.|
Zfish   584 DERYIDESQRTYIWSPVEGTDYSLGLV------LPSYSENHIRANLSDQILQVQYGSDFKDFESL 642

  Fly   736 YHRLDLNQGG--SAPPKTCRYFRQVATMDAPTLFLSAAAFESPFGFLHNNRPRTQLRHVESIMAY 798
            ......::|.  .||.:.|:...                       |.||.....|..:..:...
Zfish   643 LPNTFESEGHVFIAPREYCKDLE-----------------------LSNNNTEFLLNFIALMEKV 684

  Fly   799 LRDS----SGLLANMGLRPSIRHEVGVLYQAMQQLRRRHQDARGSLRSH-VIRRYIASVSGVLQL 858
            ..||    :.||.|:.|      :.|::.|.:.::.:.:     .|.:: .:..:.|:..|:.::
Zfish   685 TPDSKQCDNFLLHNLIL------DTGIIKQLVDRVWKIN-----DLNTYGFLAVFAATDGGITRV 738

  Fly   859 YPGCLLSS---SYDPTRRPWFRQAIAQPGKIVSTAPYLDAGG---------AGYIITIAHTIFEG 911
            :|.....:   ..:|....::|:::...|.|. .|||..|..         .|.:::.|..|..|
Zfish   739 FPNKAAETWEEDSEPFNASYYRRSLDNKGYIF-RAPYRTANDDIINPENDTIGILVSTAVDITMG 802

  Fly   912 KAHALHSAQQDRPVAV-VALDV-PYAFYYRLILEG--------------TPICQL------PHIK 954
            ..:.       :|..| |.||: .:...::::...              |..|::      ..:.
Zfish   803 SRNL-------KPAVVGVKLDLEAWTDKFKILASNHTDSNRLSSQTCGPTSGCEMDCEANSDDLL 860

  Fly   955 CLLFEHEGYLL 965
            |.|.:..|:|:
Zfish   861 CYLIDDGGFLI 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16868	NP_611469.1	vWFA	308..>426	CDD:469594	29/131 (22%)
		HK_sensor	<867..933	CDD:365792	17/76 (22%)
cacna2d2a	NP_001013521.4	None