DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16868 and Ca-Ma2d

DIOPT Version :9

Sequence 1:	NP_611469.1	Gene:	CG16868 / 37298	FlyBaseID:	FBgn0034498	Length:	1449	Species:	Drosophila melanogaster
Sequence 2:	NP_001260486.1	Gene:	Ca-Ma2d / 34951	FlyBaseID:	FBgn0261999	Length:	1215	Species:	Drosophila melanogaster

Alignment Length:	1051	Identity:	190/1051 - (18%)
Similarity:	360/1051 - (34%)	Gaps:	338/1051 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 AKIQEIFDSMHFSSAKGASNTRQASSNDSNVVNPQLQRDLQLFSERLSKKI-------QKATYVV 143
            |..|:|..|..........|.|....|.:.::. .:.:::   ...|::|:       ::|.||
  Fly    68 ALAQKITKSQEIKEKYKEYNARVELKNGTELIK-SITKNV---GRMLARKMDAVRCIQERAEYV- 127

  Fly   144 LELRELLRYNLTKVWQ--------YSYDDEDDESESEMDLEMELEDLHARNTASPTDEHVQLYLN 200
               .|...:|||...|        ||..:.:...|.|.: |.|...:: ||.....|.|   :.|
  Fly   128 ---NENFEFNLTYALQNFTYFSSKYSTFNGNSSEELEPN-EAEFAWMY-RNMELNPDTH---FYN 184

  Fly   201 TQIESCQPDYETDLEYGSSSTQSIHYNRQQIQILNYLKSDDARATFLNENNARSLAVN-GYISNQ 264
            |.:         |.|:.|....|..::|.:..:...:.|:.....| .:|.....|:: .|..:.
  Fly   185 TPV---------DTEHSSVHVPSNIWDRSERVLKTIMWSEHLDEVF-RQNYQSDPALSWQYFGSD 239

  Fly   265 LVLLKRRLSRSDAENSNSKPISGNHFKHIYFLSNSDGASASLHFRQLYV-SAIKQKFVLFLIDVG 328
            ..:|:...:   |:.::::|            :..|..:.....|..|: :|...|.::.|:|..
  Fly   240 TGILRHYPA---AQWTDTRP------------NRDDADTYDCRKRSWYIETATCSKDIVILLDHS 289

  Fly   329 SALSAELFDLSKSFVHEMLQLLEDTDKVSLVTVASEANFMSLEAFPAEAGHGIYSATRAHKEEII 393
            .:::.....::|..:..:|....:.|..:::..:||.|    :..|...| .:..||..:.|...
  Fly   290 GSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVN----DIIPCFNG-ALVQATPENIEVFN 349

  Fly   394 SFINSLSRAQAFTNHSLGFEYSFELLHRLQQSGMINTAEQPVEFVYITRGLLTNLSDAMAVLRVV 458
            ..|..|...:.:.|.:|.:|.:|:||.:                .|.:|..:||.:...|:: :|
  Fly   350 QQIEQLDDPEGYANLTLAYETAFQLLRK----------------YYDSRHCVTNSTCNQAIM-LV 397

  Fly   459 ADGQRRLRAPVIINTCAVVLDEKRIMYEKQFLNDVASQNYTKYEIDVASWWPSGQE-ASELVGRF 522
            .||       |..||..|                     :.||.      |.:|:. .|::..|.
  Fly   398 TDG-------VAGNTTEV---------------------FQKYN------WGNGENGTSQMDTRV 428

  Fly   523 --YVLSK-------------------MHAETSLPQTSSRIF-------GPLFQERYLSDTLEVHP 559
              |:|.|                   .|.:| |.:....:.       .||..:.      |.||
  Fly   429 FTYLLGKEVTKVREIQWMACLNRGYYSHVQT-LDEVHEEVLKYVDVIATPLVLQN------EQHP 486

  Fly   560 P---------VVDADSGD-----VLVSITHAVPPY-----------------GVVGVNLYLSDLL 593
            |         ..|..:.:     :::|:  .||.:                 ||.|.::.:.|:
  Fly   487 PTWTHAFTDKTYDPKTSNEKRPRLMISV--GVPAFDRFYRHANSTNPRARLLGVAGTDVPVEDI- 548

  Fly   594 EDLLNYPSTTSSAKQGL-GYAFLLDRSTGNTLAHPAFPRPLIQRETSYPVNIAYLENATDFSS-- 655
             |.|..|     .|.|: ||:|::. :.|..|.||.. ||:   .|:..:|..|  |:.||:.
  Fly   549 -DKLTLP-----YKLGVNGYSFVVS-NNGYVLLHPDL-RPI---GTNGKMNPNY--NSIDFTEVE 600

  Fly   656 ----------------HIRDRLLREESG---NVTTDVYVGRQRL----QRTYYWQSV------LG 691
                            |||:.::|.|:.   :::...:..:.|.    ::.|::..:      ||
  Fly   601 HLFEDQSPREPGESILHIRNAMVRHEANEFKSISVKFHYDKMRRVSEEKQDYFFAPLPNTPFTLG 665

  Fly   692 FYVLCLVSSGGDTLRNVSS--TQRYNLKDTVSNYEPGYYGESM----DLLYHRLDLNQGGSAPPK 750
               :.:.|..|.|...|..  .:..::|..:|::   :.||:.    |.:|
  Fly   666 ---IVMPSEYGKTWIKVGEEVDKNKHMKINISDF---FIGENWKVHPDWVY-------------- 710

  Fly   751 TCRYFRQVATMDAPTLFLSAAAFESPFGFLHNNRPRTQLRHVESIM--------AYLRDSS---- 803
             |:|.           :|....|::         |..:||...:.|        .|..|.|
  Fly   711 -CKYH-----------YLEGHEFKT---------PEAELREFLAKMQNDWKWSEQYAEDESDWDD 754

  Fly   804 --------------GLLANMGLRPSIRHEVGVLYQAMQQLRRRHQDARGSL-RSHVIRRYIASVS 853
                          ....|..|...:..:..|...:....|....:.|..: |.....|::|::|
  Fly   755 KDDLNCGRKTLGDDAYYCNKELVNLLIFDAKVTNSSYGVWRFESDEERQLIERFRADLRFVATMS 819

  Fly   854 GVLQ---LYP----------GCLLSSSYDPTRRPWFRQAIAQ-----PGKIVSTAPYLD--AGGA 898
            |:.:   ::.          |...:::.|.|   |::.||.|     ....|.:..|.|  ...:
  Fly   820 GLTRWQFIFGEVEVDTDREFGDYHTTAIDET---WYKSAILQHHEDRAESFVYSVKYYDDPMEDS 881

  Fly   899 GYIITIAHTIFEGKAHALHSAQQDRPVAVVALDVPYAFYYRLILEGT---------PICQLPHIK 954
            ...:|.:|.||.      ....::.|..||.....:|..:......|         |||....:.
  Fly   882 EVKVTASHAIFP------RDGGKEAPACVVGFQFSHARMWERFFNITAVDHCNHCLPICTDDDVD 940

  Fly   955 CLLFEHEGYLL 965
            |::.::..|::
  Fly   941 CVVIDNNAYIV 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16868	NP_611469.1	vWFA	308..>426	CDD:294047	25/118 (21%)
CG16868	NP_611469.1	Cache_1	559..627	CDD:280839	20/99 (20%)
Ca-Ma2d	NP_001260486.1	VWA_N	124..251	CDD:285584	32/148 (22%)
		vWA_VGCC_like	267..461	CDD:238740	48/250 (19%)
		Cache_1	510..587	CDD:280839	22/90 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910