Protein Alignment CG16868 and Cachd1

DIOPT Version :10

• Sequence 1: NP_611469.1
• Gene: CG16868 / 37298
• FlyBaseID: FBgn0034498
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: NP_932154.1
• Gene: Cachd1 / 320508
• MGIID: 2444177
• Length: 1288
• Species: Mus musculus
• Alignment Length: 1454
• Identity: 413/1454 - (28%)
• Similarity: 657/1454 - (45%)
• Gaps: 316/1454 - (21%)

  Fly    71 MEGKLRNIRNTELRVAKIQEIFDSMHFSSAKGASNTRQASSNDSNVVNPQLQRDLQLFSERLSKK 135
            :..::|.:...||.|..:|.||:|:.:        |.:.|:.:|.|             ::|:||
Mouse    62 LASQMRRLAAEELGVVTMQRIFNSLVY--------TEKISNGESEV-------------QQLAKK 105

  Fly   136 IQKATYVVLELRELLRYNLTKVWQYSYDDEDDESESEMDLEMELEDLHARNTASPTDEHVQLYLN 200
            |::            ::|       .|.|..:.:      :..:|..:..:..||.
Mouse   106 IRE------------KFN-------RYLDVVNRN------KQVVEASYTAHLTSPL--------- 136

  Fly   201 TQIESC---QPD-YETDLEYGSSSTQSIHYNRQQIQILNYLKSDDARATFLNE---NNARSLAVN 258
            |.|:.|   .|. .|.|..:.::.::::              |.|..:|.:|.   |..|.|
Mouse   137 TAIQDCCTIPPSMMEFDGNFNTNVSRTV--------------SCDRLSTTVNSRAFNPGRDL--- 184

  Fly   259 GYISNQLVLLKRRLSRSDAENSNSKPISGNHFKHIYFLSNSDG-------------ASASLHFRQ 310
                |.::          |:|..|.|    ..|..|| |:.:|             .|.....|.
Mouse   185 ----NSVL----------ADNLKSNP----GIKWQYF-SSEEGIFTVFPAHKFRCKGSYEHRSRP 230

  Fly   311 LYVSAIK--QKFVLFLIDVGSALSAELFDLSKSFVHEMLQLLEDTDKVSLVTVASEANFMSLEAF 373
            :|||.::  .|.::.::|.|::::.....::|.....:|..:::.||:|::|||......||:..
Mouse   231 IYVSTVRPQSKHIVVILDHGASVTDTQLQIAKDAAQVILSAIDEHDKISVLTVADAVRTCSLDQC 295

  Fly   374 PAEAGHGIY--SATRAHKEEIISFINSLSRAQAFTNHSLGFEYSFELLHRLQQSGMINTAEQPVE 436
                 :..|  .||...|.::.:|::|:..:.:.|.|::||..:|:|:.....|.... |...:.
Mouse   296 -----YKTYLSPATSETKRKMSTFVSSVKPSDSPTQHAVGFHRAFQLIRSTSNSTRFQ-ANTDMV 354

  Fly   437 FVYITRGLLTNLS---DAMAVLRVVADGQRRLRAPVIINTCAVVLDEKRIMYEKQFLNDVASQNY 498
            .:|::.|:.:..|   |..|.|||:.:....|...|:|.|.|::.|....:.|..||.|:|.||.
Mouse   355 IIYLSAGITSKDSSEEDKKATLRVINEENGFLNNSVMILTYALMNDGVTGLKELAFLRDLAEQNS 419

  Fly   499 TKYEIDVASWWP------------SGQEASELVGRFYVLSKMHAETSLP--QTSSRIFGPLFQER 549
            .||.|...:..|            |..|.:  |||||        |:||  .....:|...|.:
Mouse   420 GKYGIPDRTALPVIKGSMMVLNQLSNLETT--VGRFY--------TNLPNRMIDEAVFSLPFSD- 473

  Fly   550 YLSDTLEVHPPVVDADSGDVLVSITHAVPPY------GVVGVNLYLSDLLEDLLNYPSTTSSAKQ 608
                           :.||.|: :|.:.|.|      |:|||::.|:.:|||:..|..:.:|
Mouse   474 ---------------EMGDGLI-MTVSKPCYFGNLLLGIVGVDVNLAYILEDVTYYQDSLAS--- 519

  Fly   609 GLGYAFLLDRSTGNTLAHPAFPRPLIQRETSYPVNIAYLENATDFSSHIRDRLLREESGNVTTDV 673
               |.||:| ..|.||.||:..||.:..|.....:|.:.||...|.. :|..:|....|:....|
Mouse   520 ---YTFLID-DKGYTLMHPSLTRPYLLSEPPLHTDIIHYENIPKFEL-VRQNILSLPLGSQIITV 579

  Fly   674 YV--------------GRQRLQRTYYWQSVLG-FYVLCLVSSGGDTLRNVSSTQRYNLKDTVSNY 723
            .|              |::....:|.|:.|.. .::||:|....:    :...|..|| :||
Mouse   580 PVNSSLSWHINKLRETGKEAYNVSYAWKMVQDTSFILCIVVIQPE----IPVKQLKNL-NTV--- 636

  Fly   724 EPGYYGESMDLLYHRLDLNQGGSAPPKTCRYFRQVATMDAPTLFLSAAAFESPFGFLHNNRPRTQ 788
                  .|..||||||||    ...|..|.:|:|:||:::||:.|||.:|.||:.  |.::|.|:
Mouse   637 ------PSSKLLYHRLDL----LGQPSACLHFKQLATLESPTVMLSAGSFSSPYE--HLSQPETK 689

  Fly   789 LRHVESIMAYLRDSSGLLANMGLRPSIRHEV----GVLYQAMQQLRRRHQDARGSLRSHVIRRYI 849
             |.||...|||.|::.|:||.||:.|:|:||    .|..:.|.|:.      ..||.::::||||
Mouse   690 -RMVEHYTAYLSDNTRLIANPGLKFSVRNEVMATSHVTDEWMTQME------MSSLNTYIVRRYI 747

  Fly   850 ASVSGVLQLYPGCLLSSSYDPTRRPWFRQAIAQPGKIVSTAPYLDAGGAGYIITIAHTIFEGKAH 914
            |:.:|||::|||.|:..::|||||.|:..|:|.||.|..|.||||.|||||::||:|||
Mouse   748 ATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDVGGAGYVVTISHTI------ 806

  Fly   915 ALHSA----QQDRPVAVVALDVPYAFYYRLILEGTPICQLP---HIKCLLFEHEGYLLAHPSMLQ 972
              ||:    .....|||:.:|....::|:::::..|:|...   .|:|.:.|..|||:|||:::.
Mouse   807 --HSSSTQLSSGHTVAVMGIDFTLRYFYKVLMDLLPVCNQDGGNKIRCFIMEDRGYLVAHPTLVD 869

  Fly   973 P---ATLTKNQRRPHEHLTHKESYLANDMLNHGQLVRKLGCASYQNRTLQRYYAFNTSLSSILGN 1034
            |   |.|.:      :|:||||..:|||:|||...|:|..|.|:.:||:||.|.|||||...|.|
Mouse   870 PKGHAPLEQ------QHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQRSYKFNTSLVGDLTN 928

  Fly  1035 VVHGER-TKYAIALIRGSNLFAAVLNSSCDGGAFCPCSTIDRECLNCKRMDQTDCECPCECPMVG 1098
            :|||.. :||.:..|.|:|.|..::|.:||..|||.||.:||.||||.||:|.:||||||||:..
Mouse   929 LVHGSHCSKYRLTRIPGTNAFVGIVNETCDSLAFCACSMVDRLCLNCHRMEQNECECPCECPLEV 993

  Fly  1099 DSSSPSSLMYFANYTRQFPYCPPPSE--HFIALPPTTQLLSTLPNCPGSAGICETYSTQRECLGV 1161
            :..:.:    ..|...:.|.|....|  .:.|:.|..|  ..|..|..|.  |.......:|.||
Mouse   994 NECTGN----LTNAENRNPSCEVHQEPVTYTAIDPGLQ--DALQQCVNSR--CNQRMESGDCFGV 1050

  Fly  1162 MGCEWCQLDVDGNS-FSTSFCSSQASCFNGVLASLTPYGELDEMELLAAHNPQREQHAYSAFGPL 1225
            :.||||.:|.||.: ...|:|:.|..||.|::.:.:||  :|:|..:............:..||:
Mouse  1051 LDCEWCVVDSDGKTHLDKSYCAPQKECFGGIVGAKSPY--VDDMGAIGDEVITLNMIKSAPVGPV 1113

  Fly  1226 GGAIVVLVMVIGFAIYCYRHNLDAQTQEHFYVDSVQEENYGLPLSRFNFDDCKAHDEPPLGGGYD 1290
            .|.|:..:||:..|:|.|||.:..::.:|....:.||  ..:.:|....|..:..|:     .::
Mouse  1114 AGGIMGCIMVLVLAVYAYRHQIHRRSHQHMSPLAAQE--MSVRMSNLENDRDERDDD-----SHE 1171

  Fly  1291 HASAQRQLMHAADISPYHVSSGSSYRR---PPNGESDHGYSTMTPHEDSSDQQCFTLAEPLLLHD 1352
            ...........|.:...||.|....||   ....|||||||||:|.|||.:..|
Mouse  1172 DRGIISNTRFIAAVMERHVHSPERRRRYWGRSGTESDHGYSTMSPQEDSENPPC----------- 1225

  Fly  1353 KRHSKSDTMSISTSISSPTNRQQSSSQPNTHPYLSNQPTSKTERYKQVQATPSPCRGTPAGGSVY 1417
                .:|.:|....:.:..:.....:.|.|...||:    |...|:
Mouse  1226 ----NNDPLSAGVDVGNHDDDLDLDTPPQTAALLSH----KFHHYR------------------- 1263

  Fly  1418 GQTTLPLEGDKTRPHYILAPVTVH 1441
                 |........|::.|.||||
Mouse  1264 -----PHHPTLHHSHHLQAAVTVH 1282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16868	NP_611469.1	vWFA	308..>426	CDD:469594	29/121 (24%)
		HK_sensor	<867..933	CDD:365792	32/69 (46%)
Cachd1	NP_932154.1	VWA_N	103..218	CDD:462464	32/184 (17%)
		vWFA	227..422	CDD:469594	52/200 (26%)
		HK_sensor	<463..503	CDD:365792	12/56 (21%)
		dCache_1	688..882	CDD:460673	82/214 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1157..1176		2/23 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1187..1237		21/64 (33%)