Protein Alignment CG16868 and Cacna2d4

DIOPT Version :10

• Sequence 1: NP_611469.1
• Gene: CG16868 / 37298
• FlyBaseID: FBgn0034498
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: NP_001178680.2
• Gene: Cacna2d4 / 312668
• RGDID: 1562038
• Length: 1144
• Species: Rattus norvegicus
• Alignment Length: 1173
• Identity: 220/1173 - (18%)
• Similarity: 407/1173 - (34%)
• Gaps: 340/1173 - (28%)

  Fly   151 RYNLTKVWQYSYDDEDDESESEMDLEMELEDLHARNTASPTDEHVQLYLNTQIES----CQPDYE 211
            ||:.:.:.|..|.|.:.        .::::::..........|.::..|..::|:    .:...|
  Rat   101 RYSGSLLLQKKYKDAEP--------SLKIKEVDGLELVKKFSEDMETMLRRKVEAVESLVEAAEE 157

  Fly   212 TDLEYGSSSTQSIHYNRQQIQILNYLKSDD------ARATFLNENNA--RSLAVNGYISN-QL-- 265
            .||.:..::  |:.:|.....::|  :.||      ..|.||.|::|  .:|.||..:|: ||
  Rat   158 ADLNHEFNA--SLVFNYYNSVLIN--EKDDKGNYVELGAEFLLESDAHFNNLRVNVSMSSVQLPT 218

  Fly   266 ------------VLLKRRLSRSDAENSNSKPI-------SGNHFKHIY----FLSNSDGASA-SL 306
                        |.:...|:....||....|.       |...|..||    :..:.:|..| ..
  Rat   219 NVYNKDPDILNGVYMSEALNPVFVENFQRDPTLTWQYFGSSTGFFRIYPGIKWTPDENGVIAFDC 283

  Fly   307 HFRQLYV-SAIKQKFVLFLIDVGSALSAELFDLSKSFVHEMLQLLEDTDKVSLVTVASEANFMSL 370
            ..|..|: :|...|.::.|:|:..::......::|..|..:|..|.:.|.|:::......:::.
  Rat   284 RNRGWYIQAATSPKDIVILVDMSGSMKGLRMAIAKHTVTTILDTLGENDFVNIIAYNDYVHYIE- 347

  Fly   371 EAFPAEAGHGIYSATRAHKEEIISFINSLS-RAQAFTNHSLGFEYSFELLHRLQQSGMINTAEQP 434
               |...|. :..|.|.::|.....::.|. :.....:.:| .| :|::|.:.|:|...:...|.
  Rat   348 ---PCFKGI-LVQADRDNREHFKQLVDELMVKGVGIVSQAL-IE-AFQILKQFQESRQGSLCNQA 406

  Fly   435 VEFVYITRGLLTNLSDAMAVLRVVADGQRRLRAPVIINTCAVVLDEKRIMYEKQFLNDVASQNYT 499
            :  :.:|.|.   :.|...|........|::|....:....|...::        :..:|..|..
  Rat   407 I--MLVTDGA---VEDYEPVFETYNWPDRKVRVFTYLIGREVTFADR--------MKWIACNNKG 458

  Fly   500 KY-EIDVASWWPSGQEASELVGRF-YVLSKMHAETSLPQTSSRIFGPLFQERYLSDTLEVHPPVV 562
            .| :|...:      :|.|.|..: :|||:       |...:.....::.|.|:...|      :
  Rat   459 YYTQISTLA------DAQENVMEYLHVLSR-------PMVINHDHDIIWTEAYMDSRL------L 504

  Fly   563 DADSGDVLVSITHAVPPY-------------GVVGVNLYLSDLLEDLLNYPSTTSSAKQGL-GYA 613
            .:::..:::..|.|:|.:             ||||.::.|.:|::....|       |.|: |||
  Rat   505 TSEAQSLMLLTTVAMPVFSKKNETRSHGILLGVVGSDVTLRELMKLAPRY-------KLGVHGYA 562

  Fly   614 FLLDRSTGNTLAHPAFPRPLIQRETSYPVNIAYLENATDFS--------SHIRDRLLREESGNVT 670
            | |:.:.|..|:||.. |||.:..........|  |:.|.|        ..:|..::..|:|:.:
  Rat   563 F-LNTNNGYILSHPDL-RPLYREGKKLKPKPNY--NSVDLSEVEWEDQAEILRTAMINGETGSHS 623

  Fly   671 TDVYV----GRQRLQRT--YYWQSV------LGFYVLCLVSSGGDTLRNVSSTQRYNLKDTVSNY 723
            .||.|    |::.|..|  |::..:      ||   :.|....|:.:...:::....|.|.:
  Rat   624 MDVKVPLDKGKRVLFLTNDYFFTDISDTPFSLG---VVLTRGHGEYILLGNTSVEEGLHDLL--- 682

  Fly   724 EPGYYGESMDLLYHRLDLNQGGSAPPKTCRYFRQVATMDAPTLFLSAAAFESPFGFLHNNRPRTQ 788
            .|.....| |.:|...|::..          .|:::.::|...||:..   .|           .
  Rat   683 HPDLTLAS-DWIYCITDIDPD----------HRKLSQLEAVVRFLTGV---DP-----------D 722

  Fly   789 LRHVESIMAYLRDSSGLLANM-------GLRPSIRHEVGVLYQAMQQLRRRHQDARGSLRSHVIR 846
            |...|.::..:...:.:.|.|       .|..|...|.||            :.|....|:.::|
  Rat   723 LECDEELVREVLFDAVVTAPMEAYWTALALNISEESEPGV------------EVAFLGTRAGLLR 775

  Fly   847 R--YIAS--VSGVLQLYP---GCLLSSSYDPTRRPWFRQAIAQ-PGKIVSTAPYL---DAGG--- 897
            |  ::.|  ||....|.|   ..:.:..:.|.   |:|||..| ||..|....:.   |:.|
  Rat   776 RSLFVGSEKVSDRKFLTPEDEASIFTMDHFPL---WYRQASEQPPGSFVFNLRWAEGPDSPGKPV 837

  Fly   898 ---AGYIITIAHTIFEGKAHALHSAQQDRPVAVVALDVPYAFYYRLI---------LEGTPI--- 947
               |...||:.   .:||...         .|.|.:.:...:..|..         :|| |.
  Rat   838 AVRASTAITVT---VDGKTAI---------AAAVGIQMQADYLQRQFWAAMQQCNTVEG-PCPKR 889

  Fly   948 CQLPHIKCLLFEHEGYLLAHPSMLQPATLTKNQRRPHE---HLTHKESYLANDMLNHG------- 1002
            ||...:.|.:.::.|::|.             ..||.|   .|...:..|...:|:.|
  Rat   890 CQDTDLDCFVIDNNGFILI-------------SERPQEIGRLLGEADGALMTQLLSMGVFSRVTM 941

  Fly  1003 ------------------QLVRKLGC----------------------ASYQNRTLQRYYAFNTS 1027
                              .|:..|..                      .|:|::..:....|:.|
  Rat   942 YDYQAMCKPPDHHHSAAESLISPLSAFLTVAKWLLHECLLFLFEWSAWGSWQDKGSEAKAVFHHS 1006

  Fly  1028 LSSILGNVVHGERTKYAIAL-------------------------IRGSNLFAAVLNSSCDGGAF 1067
            ......:::|...|:|.:.:                         |..|||...|.:.:||..|:
  Rat  1007 HKHKKQDLLHPCDTEYPVFVHQTAIREANGIIECGGCQKTFVMQQIPSSNLLLLVTDRTCDCSAY 1071

  Fly  1068 CPCSTIDRE-----CLNCKRMDQT-------DC------ECPCECPMVGDSSSPSSLMYFANYTR 1114
            .|......|     .:.|.||...       .|      |...:|....|:...|.|:..|.:..
  Rat  1072 SPILQEATEVKYNASVKCNRMRSQKPRRRPGSCHAFHPEENAQDCGGASDTLPSSPLLLLALWAW 1136

  Fly  1115 QFP 1117
            :.|
  Rat  1137 RLP 1139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16868	NP_611469.1	vWFA	308..>426	CDD:469594	23/119 (19%)
		HK_sensor	<867..933	CDD:365792	18/75 (24%)
Cacna2d4	NP_001178680.2	VWA_N	155..271	CDD:462464	28/119 (24%)
		vWA_VGCC_like	284..467	CDD:238740	36/202 (18%)
		HK_sensor	<491..544	CDD:365792	10/58 (17%)
		HK_sensor	546..659	CDD:365792	32/126 (25%)
		VGCC_alpha2	668..1117	CDD:462488	88/517 (17%)