Protein Alignment CG16868 and Cacna2d3

DIOPT Version :10

• Sequence 1: NP_611469.1
• Gene: CG16868 / 37298
• FlyBaseID: FBgn0034498
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: XP_063131356.1
• Gene: Cacna2d3 / 306243
• RGDID: 631361
• Length: 1091
• Species: Rattus norvegicus
• Alignment Length: 1128
• Identity: 215/1128 - (19%)
• Similarity: 400/1128 - (35%)
• Gaps: 338/1128 - (29%)

  Fly   151 RYNLTKVWQYSYDD-EDDESESEMD-------LEMELEDL-HARNTASPTDEHVQLYLNTQIESC 206
            :|:.:::.|..|.: |.|.:..|:|       |...:|:: |.::.|          :...:|:.
  Rat    59 KYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEA----------VRRLVEAA 113

  Fly   207 QP-----DYETDLEYGSSSTQSIHYNRQQIQILNYLKSDDARATFLNENNARSLAVNGYISNQLV 266
            :.     :::.||:|.       ::|...|      ...|....||.......||.|.:.:|
  Rat   114 EEAHLKHEFDADLQYE-------YFNAVLI------NERDKDGNFLELGKEFILAPNDHFNN--- 162

  Fly   267 LLKRRLSRSDAE------NSNSKPISGNHFK---HIYFLSNSDG---------ASASLHFRQL-- 311
             |...:|.||.:      |.:...::|.::.   :..|:.|.|.         .||...|||.
  Rat   163 -LPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPG 226

  Fly   312 --------------------YV-SAIKQKFVLFLIDVGSALSAELFDLSKSFVHEMLQLLEDTDK 355
                                |: :|...|.|:.|:||..::......::|..|..:|..|.|.|.
  Rat   227 IKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDF 291

  Fly   356 VSLVTVASEANFMSLEAFPAEAGHGIYSATRAHKEEIISFINSLSRAQAFTNHSLGFEYSFELLH 420
            .:::|...|.:::.    |...| .:..|.|.:||.....::.|. |:......:....:|.:|.
  Rat   292 FNIITYNEELHYVE----PCLNG-TLVQADRTNKEHFREHLDKLF-AKGIGMLDIALNEAFNVLS 350

  Fly   421 RLQQSGMINTAEQPVEFVYITRGLLTNLSDAMAVLRVVADGQRRLRA-PVIINTCAVVLDEKRIM 484
            ....:|..:...|.:  :.||.|.:.......|....   .:|::|. ..:|...|...|..:.|
  Rat   351 DFNHTGQGSICSQAI--MLITDGAVDTYDTIFAKYNW---PERKVRIFTYLIGREAAFADNLKWM 410

  Fly   485 --YEKQFLNDVAS-----QNYTKYEIDVASWWPSGQEASELVGRFYVLSKMHAETSLPQTSSRIF 542
              ..|.|...:::     :|..:|                    .:|||:       |:...:..
  Rat   411 ACANKGFFTQISTLADVQENVMEY--------------------LHVLSR-------PKVIDQEH 448

  Fly   543 GPLFQERYLSDTLEVHPPVVDADSGDVLVSITHAVPPY-------------GVVGVNLYLSDLLE 594
            ..::.|.|:..||.....:.| |.|.||:: |.|:|.:             ||||.::.:.:||:
  Rat   449 DVVWTEAYIDSTLPQAQKLAD-DQGLVLMT-TVAMPVFSKQNETRSKGILLGVVGTDVPVKELLK 511

  Fly   595 DLLNYPSTTSSAKQGL-GYAFLLDRSTGNTLAHPAFPRPLIQ-----RETSY-PVNIAYLENATD 652
            .:..|       |.|: ||||.: .:.|..|.||.. |||.:     |:.:| .|:::.:| ..|
  Rat   512 TIPKY-------KLGIHGYAFAI-TNNGYILTHPEL-RPLYEEGKKRRKPNYSSVDLSEVE-WED 566

  Fly   653 FSSHIRDRLLREESGNVTTDVY----VGRQRLQRT--YYWQSVLG--FYVLCLVSSGGDTLRNVS 709
            ....:|:.::..::|..:.:|.    .|::.|..|  ||:..:.|  |.:...:|.|..
  Rat   567 RDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGAPFSLGVALSRGHG------ 625

  Fly   710 STQRYNLKDTVSNYEPGYYGESMDL------LYHRLDLNQGGSAPPKTCRYFRQVATMDAPTLFL 768
               :|..:..|:..|..:..|..|:      .|...||:      |:    .|.::.::|..|:|
  Rat   626 ---KYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLH------PE----HRHLSQLEAIKLYL 677

  Fly   769 S----------------------AAAFESPFGFLHNNRPRTQLRHVESIMAYLRDSSGLLANMGL 811
            .                      :|..|:.:..|..|:.....:.||  :|:|...:||
  Rat   678 KGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVE--VAFLGTRTGL------ 734

  Fly   812 RPSIRHEVGVLYQAMQQLRRRHQDARGSLRSHVIRRYIASVSGVLQLYPGCLLSSSYDPTRRPWF 876
                 ..:.:...|.|...:....||....                     :.::.:.|.   |:
  Rat   735 -----SRINLFVGAEQLTNQDFLKARDKEN---------------------IFNADHFPL---WY 770

  Fly   877 RQAIAQ-PGKIVSTAPYLDAG--GAGYIITIAHTIFEGKAHALHSAQQDRPVAVVALDVPYAFYY 938
            |:|..| ||..|.:.|: ..|  ....::|.:.:|      .|...::...||.|.:.:...|:.
  Rat   771 RRAAEQIPGSFVYSIPF-STGTVNKSNVVTASTSI------QLLDERKSPVVAAVGIQMKLEFFQ 828

  Fly   939 RLI---------LEG--TPICQLPHIKCLLFEHEGYLLAHPSMLQP---------ATLTK----- 978
            |..         |:|  :..|....:.|.|.::.|::|......|.         |.:.|
  Rat   829 RKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDFFGEVEGAVMNKLLTMG 893

  Fly   979 ----------------NQRR---------PHEHLTHKESYLANDMLN-----------HGQLVRK 1007
                            |:..         |::.......::..:::.           |..:..|
  Rat   894 SFKRITLYDYQAMCRANKESSDSAHGLLDPYKAFLSAAKWIVTELVLFLVEFNLCSWWHSDMTAK 958

  Fly  1008 LGCASYQNRTLQ----RYYAF--NTSLSSILGNVVHGERTK-YAIALIRGSNLFAAVLNSSCDGG 1065
               |....:||:    .|.||  ..::....||:...:.:| :.|..|..||||..|::|||...
  Rat   959 ---AQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCE 1020

  Fly  1066 AFCPCSTID-----RECLNCKRM 1083
            :..|.:...     .|.|.|:|:
  Rat  1021 SVAPITMAPIEIRYNESLKCERL 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16868	NP_611469.1	vWFA	308..>426	CDD:469594	28/140 (20%)
		HK_sensor	<867..933	CDD:365792	16/68 (24%)
Cacna2d3	XP_063131356.1	None