Protein Alignment CG16868 and Cacna2d2

DIOPT Version :9

• Sequence 1: NP_611469.1
• Gene: CG16868 / 37298
• FlyBaseID: FBgn0034498
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: NP_783182.1
• Gene: Cacna2d2 / 300992
• RGDID: 631360
• Length: 1157
• Species: Rattus norvegicus
• Alignment Length: 1276
• Identity: 237/1276 - (18%)
• Similarity: 433/1276 - (33%)
• Gaps: 468/1276 - (36%)

  Fly    45 MPLQQSPGS---VFFVHHNQQN-AMQLRHSMEGKLRNIRNTELRVAKIQEIFDSMHFSSAKGASN 105
            :||..:||:   .|...|..|: |.:|...::|.:|....    |.:::||:        |...|
  Rat    54 LPLLTAPGASAYSFPQQHTMQHWARRLEQEIDGVMRIFGG----VQQLREIY--------KDNRN 106

  Fly   106 TRQASSNDSNVVNPQLQRDLQLFSERLSKKIQKATYVVLELRELLRYNLTKVWQYSYDDE----- 165
            ......|:...:..::..|::...:|..:.:::........::..|      ||.:..:|
  Rat   107 LFDVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHR------WQDNIKEEDIMYY 165

  Fly   166 DDESESEMDLEMELEDLHARNTASPTDEHVQLYLNTQIESCQPDYETDLEYGSSSTQSIHYNRQQ 230
            |.::::|:| :.|.||:...:..|      .|.|:. ||  :|:::..:.|.        |...|
  Rat   166 DAKADAELD-DPESEDMERGSKTS------ALRLDF-IE--EPNFKNKVNYS--------YTAVQ 212

  Fly   231 IQILNYLKSDDARATFLNENNARSLAVNGYISNQL---VLLKRRLSRSDAENSNSKPISGNHFKH 292
            |....|..|    ...|||.|......|.:|.|:.   .||.:....:.....
  Rat   213 IPTDIYKGS----TVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTR------------ 261

  Fly   293 IYFLSNSDGASASLHF-----RQLYV-SAIKQKFVLFLIDVGSALSAELFDLSKSFVHEMLQLLE 351
             |:.:....|...:..     |..|: .|...|.::.::||..::|.....|.|:.|.|||..|.
  Rat   262 -YYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLS 325

  Fly   352 DTDKVSLVTVASEANFMSLEAFPAEAGHGIYSATRAHKEEIISFINSLSRAQAFTNHSLGFEYSF 416
            |.|.|::.:...:|..:|......:|.   ....:..||.:...:     |:..|.:..||||:|
  Rat   326 DDDYVNVASFNEKAQPVSCFTHLVQAN---VRNKKVFKEAVQGMV-----AKGTTGYKAGFEYAF 382

  Fly   417 ELLHRLQQSGMINTAEQPVEFVYITRGLLTNLSDAMAVLRVVADGQRRLRAPVIINTCAVVLDEK 481
            :   :||.|.             |||      ::...::.:..||..               |..
  Rat   383 D---QLQNSN-------------ITR------ANCNKMIMMFTDGGE---------------DRV 410

  Fly   482 RIMYEKQ---------FLNDVASQNYTKYEIDVASWW-----------PS-------GQEASELV 519
            :.::||.         |...|...|   |::....|.           ||       .||..:::
  Rat   411 QDVFEKYNWPNRTVRVFTFSVGQHN---YDVTPLQWMACTNKGYYFEIPSIGAIRINTQEYLDVL 472

  Fly   520 GRFYVLSKMHAETSLPQTSSRIFGPLFQERYLSDTLEVHPPVVDADSGDVLVSITHAVPPY---- 580
            ||..||:.                        .|..:|....|..|:..:.:.:|..:|.:
  Rat   473 GRPMVLAG------------------------KDAKQVQWTNVYEDALGLGLVVTGTLPVFNLTQ 513

  Fly   581 ------------GVVGVNLYLSDLLEDLLNYPSTTSSAKQGLGYAFLLDRSTGNTLAHPAFPRPL 633
                        ||:|:::.|:|:.....||   |..|.   ||.|.:|.: |..|.||.. :|.
  Rat   514 DGPGDKKNQLILGVMGIDVALNDIKRLTPNY---TLGAN---GYVFAIDLN-GYVLLHPNL-KPQ 570

  Fly   634 IQ--RETSYPVNIAYLENATDFSSHIRDRLLREESGNVTTDVYVGRQRLQRTYYWQSVLGFYVLC 696
            |.  ||   ||.:.:|           |..|.:|:          ::.::|:    .:.|
  Rat   571 ITNFRE---PVTLDFL-----------DAELEDEN----------KEEIRRS----MIDG----- 602

  Fly   697 LVSSGGDTLRNV--SSTQRYNLKDTVSNY------EPGYYGESMDLLYHRLDLNQGGSAPPKTCR 753
              ..|...:|.:  |..:|| :.:.:.||      ...|   |:.|:           .||.:..
  Rat   603 --DKGHKQIRTLVKSLDERY-IDEVIRNYTWVPIRSTNY---SLGLV-----------LPPYSTY 650

  Fly   754 YFR-----QVATMDAPTL------FLSAAAFES-------PFGF---LHNNRPRTQ-LRHVESIM 796
            |.:     |:..:..|..      ||..::|||       |..:   |:.:...|: |::...:|
  Rat   651 YLQANLSDQILQVKLPISKLKDFEFLLPSSFESEGHVFIAPREYCKDLNASDNNTEFLKNFIELM 715

  Fly   797 AYLRDSSG-----LLANMGLRPSIRHEVGVLYQAMQQLRRRHQDARGSLRSH-VIRRYIASVSGV 855
            ..:...|.     ||.|:.|      :.|:..|.:::: .|.||    |.:: ::..:.|:..|:
  Rat   716 EKVTPDSKQCNNFLLHNLIL------DTGITQQLVERV-WRDQD----LNTYSLLAVFAATDGGI 769

  Fly   856 LQLYPGCLLSSSYDPTRRP------WFRQAIAQPGKIVSTAPYLDA---------GGAGYIITIA 905
            .:::|.   .::.|.|..|      ::|:::...|.|.. .|:.|:         ...|.:::.|
  Rat   770 TRVFPN---KAAEDWTENPEPFNASFYRRSLDNRGYIFK-PPHQDSLLRPLELENDTVGVLVSTA 830

  Fly   906 HTIFEGKAHALHSAQQDRPVAV-VALDV-PYAFYYRLILEG-------------TPICQL----- 950
            ..:..|:       :..||..| |.||: .:|..::::...             :..|::
  Rat   831 VELSLGR-------RTLRPAVVGVKLDLEAWAEKFKVLASNRTHQDQPQKQCGPSSHCEMDCEVN 888

  Fly   951 -PHIKCLLFEHEGYLLAHPSMLQPATLTKNQRRPHEHL---------------------THKESY 993
             ..:.|:|.:..|:|           :..||....:.:                     |.||||
  Rat   889 NEDLLCVLIDDGGFL-----------VLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESY 942

  Fly   994 ------------------------LANDMLN-----------------HGQL------------- 1004
                                    ...|.||                 :|.:
  Rat   943 DYQAACAPQPPGNLGAAPRGVFVPTIADFLNLAWWTSAAAWSLFQQLLYGLIYHSWFQADPAEAE 1007

  Fly  1005 ----VRKLGCASYQNRTLQRYY--AFNTSLSSIL--GN---VVHGERTKYAIALIRGSNLFAAV- 1057
                .|:..|...|.    :||  :.|.|.::|:  ||   :.|.:|       :..:||...|
  Rat  1008 GSPETRESSCVMKQT----QYYFGSVNASYNAIIDCGNCSRLFHAQR-------LTNTNLLFVVA 1061

  Fly  1058 ---LNSSCDGGAFCPCSTIDRECLNCKRMDQTDCECPCECP 1095
               |.|.|:.|                |:.|.:..||.:.|
  Rat  1062 EKPLCSQCEVG----------------RLLQKETHCPADGP 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16868	NP_611469.1	vWFA	308..>426	CDD:294047	31/123 (25%)
		Cache_1	559..627	CDD:280839	19/83 (23%)
Cacna2d2	NP_783182.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		VWA_N	144..268	CDD:285584	32/164 (20%)
		vWA_VGCC_like	280..459	CDD:238740	47/226 (21%)
		MIDAS-like motif	300..304		2/3 (67%)
		Cache_1	488..576	CDD:280839	23/95 (24%)
		VGCC_alpha2	583..666	CDD:285647	20/129 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810