DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16868 and Cacna2d1

DIOPT Version :9

Sequence 1:	NP_611469.1	Gene:	CG16868 / 37298	FlyBaseID:	FBgn0034498	Length:	1449	Species:	Drosophila melanogaster
Sequence 2:	NP_037051.2	Gene:	Cacna2d1 / 25399	RGDID:	2247	Length:	1091	Species:	Rattus norvegicus

Alignment Length:	1233	Identity:	245/1233 - (19%)
Similarity:	422/1233 - (34%)	Gaps:	373/1233 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VAKIQEIFDSMHFSSAKGASNTRQASS-----NDSNVVNPQLQRDLQLFSER-----LSKKIQKA 139
            |.|:||...::    ||.||...|.:.     .|...|.|...|.|...:.|     ||.:.:..
  Rat    37 VDKMQEDLVTL----AKTASGVTQLADIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKAL 97

  Fly   140 TYVVLEL---------------RELLRYNLTKVWQYSYDDEDDE-SESEMDLE----MELEDLHA 184
            ..:.:|.               .|::.||       :.||.|.| :|||...:    :.:||.:.
  Rat    98 VRLAMEAEKVQAAHQWREDFASNEVVYYN-------AKDDLDPERNESESGSQRIKPVFIEDANF 155

  Fly   185 RNTASPTDEHVQLYLNTQIESCQPDYETDLEYGSSSTQSIHYNRQQIQILNYLKSDDARATFLNE 249
            ....|  .:|..:::.|.|.........:|.:.|:..:....||.:...|  |......||.|
  Rat   156 GRQIS--YQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKRNRDEDPTL--LWQVFGSATGL-- 214

  Fly   250 NNARSLAVNGYISNQLVLLKRRLSRSDAENSNSKP--ISGNHFKHIYFLSNSDGASASLHFRQLY 312
              ||....:.::.|     .|..::.|..:...:|  |.|
  Rat   215 --ARYYPASPWVDN-----SRTPNKIDLYDVRRRPWYIQG------------------------- 247

  Fly   313 VSAIKQKFVLFLIDVGSALSAELFDLSKSFVHEMLQLLEDTDKVSLVTVAS-EANFMSLEAFPAE 376
              |...|.:|.|:||..::|.....|.::.|.|||:.|.|.|   .|.||| .:|...:..|.
  Rat   248 --AASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDD---FVNVASFNSNAQDVSCFQ-- 305

  Fly   377 AGHGIYSATRAHKEEIISFINSLSRAQAFTNHSLGFEYSFELLHRLQQSGMINTAEQPVEFVYIT 441
              |.:.:..| :|:.:...:|::: |:..|::..||.::||.|
  Rat   306 --HLVQANVR-NKKVLKDAVNNIT-AKGITDYKKGFSFAFEQL---------------------- 344

  Fly   442 RGLLTNLSDAMA--VLRVVADGQRRLRAPVIINTCAVVLDEKRIMYEKQFLNDVASQNYTK---- 500
              |..|:|.|..  ::.:..||... ||..|.   |....:|::   :.|...|...||.:
  Rat   345 --LNYNVSRANCNKIIMLFTDGGEE-RAQEIF---AKYNKDKKV---RVFTFSVGQHNYDRGPIQ 400

  Fly   501 ----------YEI-DVASWWPSGQEASELVGRFYVLSKMHAETSLPQTSSRIFGPLFQERYLSDT 554
                      ||| .:.:...:.||..:::||..||:...|:
  Rat   401 WMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAK----------------------- 442

  Fly   555 LEVHPPVVDADSGDVLVSITHAVPPY------------------GVVGVNLYLSDLLEDLLNYPS 601
             :|....|..|:.::.:.||..:|.:                  ||:||::.|.|:......:..
  Rat   443 -QVQWTNVYLDALELGLVITGTLPVFNVTGQSENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTL 506

  Fly   602 TTSSAKQGLGYAFLLDRSTGNTLAHPAF-PRPLIQRETSYPVNIAYL--ENATDFSSHIRDRLLR 663
            ..:      ||.|.:| ..|..|.||.. |:   ..::..||.:.:|  |...|....||::::.
  Rat   507 CPN------GYYFAID-PNGYVLLHPNLQPK---NPKSQEPVTLDFLDAELENDIKVEIRNKMID 561

  Fly   664 EESGNVTTDVYVGRQ------RLQRTYYWQSVLGF-YVLCLV----------SSGGDTLRNVSST 711
            .|||..|....|..|      :..|||.|..|.|. |.|.||          :...:|:....|
  Rat   562 GESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKIEETITQARS- 625

  Fly   712 QRYNLKDTVSNYEPGYYGESMDLLYHRLDLNQGGS--APPKTCRYFRQVATMDAPTLFLSAAAFE 774
            ::..:||: ...:|..:.||            |.:  ||.:.|   ..:...|..|.||  ..|.
  Rat   626 KKGKMKDS-ETLKPDNFEES------------GYTFIAPREYC---NDLKPSDNNTEFL--LNFN 672

  Fly   775 SPFGFLHNNRPRTQLRHVESIMAYLRDSSGLLANMGLRPSIRHEVGVLYQAMQQLRRRHQDARGS 839
            .   |:....|.....:.:.|...|.|:                 |...:.:|....:.::.:|
  Rat   673 E---FIDRKTPNNPSCNTDLINRILLDA-----------------GFTNELVQNYWSKQKNIKG- 716

  Fly   840 LRSHVIRRYIASVSGVLQLYP---GCLLSSSYDPTRRPWFRQAIAQPGKIVSTAPYLDAGGAGYI 901
                |..|::.:..|:.::||   |.....:.:.....:::::: .....|.||||.:..|.|
  Rat   717 ----VKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSL-DNDNYVFTAPYFNKSGPG-- 774

  Fly   902 ITIAHTIFEGKAHALHSAQQDRPVAVVALDVPYAFYYRLILEGT-------PICQLPH----IKC 955
             .....|...||..|:...:....|||.:.:....:.....:.:       |:|....    :.|
  Rat   775 -AYESGIMVSKAVELYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDC 838

  Fly   956 LLFEHEGYLL-----------------AHPSMLQP---------------ATLTKNQRRPHEHLT 988
            ::.:..|:||                 ..|||::.               .::......|.:...
  Rat   839 VILDDGGFLLMANHDDYTNQIGRFFGEIDPSMMRHLVNISLYAFNKSYDYQSVCDPGAAPKQGAG 903

  Fly   989 HKESYLAN--DMLNHG------------QLVRKLG---------------CASYQNR---TLQRY 1021
            |:.:|:.:  |:|..|            ||:..|.               .||...:   |.|..
  Rat   904 HRSAYVPSITDILQIGWWATAAAWSILQQLLLSLTFPRLLEAVEMEEDDFTASLSKQSCITEQTQ 968

  Fly  1022 YAFNTSLSSILGNVVHGERTK-YAIALIRGSNLFAAVLNSSCDGGAFCPCSTIDRECLNCKRMDQ 1085
            |.|.....|..|.:..|..:: :.:..:..:||...::.|.    ..|||.|  |..:   :.:|
  Rat   969 YFFKNDTKSFSGLLDCGNCSRIFHVEKLMNTNLVFIMVESK----GTCPCDT--RLLM---QAEQ 1024

  Fly  1086 TDCECPCECPMVGDSSSPSSLMYFANYTRQFPYCPPPSEHFIALPPTTQLLSTLPNCPGSAGI 1148
            |. :.|..|.||                :|..|...|...|     ...:|....:|.|.:|:
  Rat  1025 TS-DGPDPCDMV----------------KQPRYRKGPDVCF-----DNNVLEDYTDCGGVSGL 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16868	NP_611469.1	vWFA	308..>426	CDD:294047	32/118 (27%)
CG16868	NP_611469.1	Cache_1	559..627	CDD:280839	17/85 (20%)
Cacna2d1	NP_037051.2	VWA_N	104..223	CDD:285584	27/133 (20%)
		vWA_VGCC_like	239..417	CDD:238740	53/244 (22%)
		MIDAS-like motif	259..263		2/3 (67%)
		Cache_1	446..531	CDD:280839	20/94 (21%)
		VGCC_alpha2	543..627	CDD:285647	23/84 (27%)
		RAMP_I_III	<636..816	CDD:304371	40/225 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910