Protein Alignment CG16868 and Cacna2d3

DIOPT Version :10

• Sequence 1: NP_611469.1
• Gene: CG16868 / 37298
• FlyBaseID: FBgn0034498
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: NP_033915.1
• Gene: Cacna2d3 / 12294
• MGIID: 1338890
• Length: 1091
• Species: Mus musculus
• Alignment Length: 1136
• Identity: 212/1136 - (18%)
• Similarity: 398/1136 - (35%)
• Gaps: 354/1136 - (31%)

  Fly   151 RYNLTKVWQYSYDD-EDDESESEMD-------LEMELEDL-HARNTASPTDEHVQLYLNTQIESC 206
            :|:.:::.|..|.: |.|.:..|:|       |...:|:: |.::.|          :...:|:.
Mouse    59 KYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKKLAKIMEEMFHKKSEA----------VRRLVEAA 113

  Fly   207 QP-----DYETDLEYGSSSTQSIHYNRQQIQILNYLKSDDARATFLNENNARSLAVNGYISNQLV 266
            :.     :::.||:|.       ::|...|      ...|....||.......||.|.:.:|
Mouse   114 EEAHLKHEFDADLQYE-------YFNAVLI------NERDKDGNFLELGKEFILAPNDHFNN--- 162

  Fly   267 LLKRRLSRSDAE------NSNSKPISGNHFK---HIYFLSNSDG---------ASASLHFRQL-- 311
             |...:|.||.:      |.:...::|.::.   :..|:.|.|.         .||...|||.
Mouse   163 -LPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPG 226

  Fly   312 --------------------YV-SAIKQKFVLFLIDVGSALSAELFDLSKSFVHEMLQLLEDTDK 355
                                |: :|...|.|:.|:||..::......::|..|..:|..|.|.|.
Mouse   227 IKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDF 291

  Fly   356 VSLVTVASEANFMSLEAFPAEAGHGIYSATRAHKEEIISFINSLSRAQAFTNHSLGFEYSFELLH 420
            .:::|...|.:::.    |...| .:..|.|.:||.....::.|. |:......:....:|.:|.
Mouse   292 FNIITYNEELHYVE----PCLNG-TLVQADRTNKEHFREHLDKLF-AKGIGMLDIALNEAFNILS 350

  Fly   421 RLQQSGMINTAEQPVEFVYITRGLLTNLSDAMAVLRVVADGQRRLRA-PVIINTCAVVLDEKRIM 484
            ....:|..:...|.:  :.||.|.:.......|....   ..|::|. ..:|...|...|..:.|
Mouse   351 DFNHTGQGSICSQAI--MLITDGAVDTYDTIFAKYNW---PDRKVRIFTYLIGREAAFADNLKWM 410

  Fly   485 --YEKQFLNDVAS-----QNYTKYEIDVASWWPSGQEASELVGRFYVLSKMHAETSLPQTSSRIF 542
              ..|.|...:::     :|..:|                    .:|||:       |:...:..
Mouse   411 ACANKGFFTQISTLADVQENVMEY--------------------LHVLSR-------PKVIDQEH 448

  Fly   543 GPLFQERYLSDTLEVHPPVVDADSGDVLVSITHAVPPY-------------GVVGVNLYLSDLLE 594
            ..::.|.|:..||.....:.| |.|.||:: |.|:|.:             ||||.::.:.:||:
Mouse   449 DVVWTEAYIDSTLPQAQKLAD-DQGLVLMT-TVAMPVFSKQNETRSKGILLGVVGTDVPVKELLK 511

  Fly   595 DLLNYPSTTSSAKQGL-GYAFLLDRSTGNTLAHPAFPRPLIQ-----RETSY-PVNIAYLENATD 652
            .:..|       |.|: ||||.: .:.|..|.||.. |||.:     |:.:| .|:::.:| ..|
Mouse   512 TIPKY-------KLGIHGYAFAI-TNNGYILTHPEL-RPLYEEGKKRRKPNYSSVDLSEVE-WED 566

  Fly   653 FSSHIRDRLLREESGNVTTDVY----VGRQRLQRT--YYWQSVLG--FYVLCLVSSGGDTLRNVS 709
            ....:|:.::..::|..:.:|.    .|::.|..|  ||:..:.|  |.:...:|.|..
Mouse   567 RDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVALSRGHG------ 625

  Fly   710 STQRYNLKDTVSNYEPGYYGESMDL------LYHRLDLNQGGSAPPKTCRYFRQVATMDAPTLFL 768
               :|..:..|:..|..:..|..|:      .|...||:      |:    .|.::.::|..|:|
Mouse   626 ---KYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLH------PE----HRHLSQLEAIKLYL 677

  Fly   769 S----------------------AAAFESPFGFLHNNRPRTQLRHVESIMAYLRDSSGLLANMGL 811
            .                      :|..|:.:..|..|:.....:.||  :|:|...:||
Mouse   678 KGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVE--VAFLGTRTGL------ 734

  Fly   812 RPSIRHEVGVLYQAMQQLRRRHQDARGSLRSHVIRRYIASVSGVLQLYPGCLLSSSYDPTRRPWF 876
                 ..:. |:...:||..:.....|...:                    :.::.:.|.   |:
Mouse   735 -----SRIN-LFVGAEQLTNQDFLKAGDKEN--------------------IFNADHFPL---WY 770

  Fly   877 RQAIAQ-PGKIVSTAPYLDAG--GAGYIITIAHTIFEGKAHALHSAQQDRPVAVVALDVPYAFYY 938
            |:|..| .|..|.:.|: ..|  ....::|.:.:|      .|...::...||.|.:.:...|:.
Mouse   771 RRAAEQIAGSFVYSIPF-STGTVNKSNVVTASTSI------QLLDERKSPVVAAVGIQMKLEFFQ 828

  Fly   939 RLI---------LEG--TPICQLPHIKCLLFEHEGYLLAHPSMLQPATLTKNQRRPHEHLTHKES 992
            |..         |:|  :..|....:.|.|.::.|::|          ::::..:..:.....|.
Mouse   829 RKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFIL----------VSEDYTQTGDFFGEVEG 883

  Fly   993 YLANDMLNHGQLVRKLGCASYQ-------------NRTLQRYYAFNTSLSSILGNVV-------- 1036
            .:.|.:|..|.. :::....||             :..|..|.||.::...|:..:|
Mouse   884 AVMNKLLTMGSF-KRITLYDYQAMCRANKESSDSAHGLLDPYKAFLSAAKWIMTELVLFLVEFNL 947

  Fly  1037 ----HGERT----------------------------------------KYAIALIRGSNLFAAV 1057
                |.:.|                                        .:.|..|..||||..|
Mouse   948 CSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVV 1012

  Fly  1058 LNSSCDGGAFCPCSTID-----RECLNCKRM 1083
            ::|||...:..|.:...     .|.|.|:|:
Mouse  1013 VDSSCLCESVAPITMAPIEIRYNESLKCERL 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16868	NP_611469.1	vWFA	308..>426	CDD:469594	28/140 (20%)
		HK_sensor	<867..933	CDD:365792	15/68 (22%)
Cacna2d3	NP_033915.1	VWA_N	113..229	CDD:462464	26/132 (20%)
		vWA_VGCC_like	242..425	CDD:238740	39/193 (20%)
		MIDAS-like motif	262..266		2/3 (67%)
		dCache_1	<439..569	CDD:460673	39/148 (26%)
		PDC2_MCP_like	508..622	CDD:350337	31/123 (25%)
		VGCC_alpha2	655..1068	CDD:462488	75/454 (17%)