DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG16868 and Cacna2d1

DIOPT Version :9

Sequence 1:NP_611469.1 Gene:CG16868 / 37298 FlyBaseID:FBgn0034498 Length:1449 Species:Drosophila melanogaster
Sequence 2:XP_011248046.1 Gene:Cacna2d1 / 12293 MGIID:88295 Length:1110 Species:Mus musculus


Alignment Length:1264 Identity:243/1264 - (19%)
Similarity:419/1264 - (33%) Gaps:416/1264 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 VAKIQEIFDSMHFSSAKGASNTRQASS-----NDSNVVNPQLQRDLQLFSER-----LSKKIQKA 139
            |.|:||...::    ||.||...|.:.     .|...|.|...|.|...:.|     ||.:.:..
Mouse    37 VDKMQEDLVTL----AKTASGVTQLADIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKAL 97

  Fly   140 TYVVLELRELLRYNLTKVWQYSYDDEDDESESEM-------DLEMELEDLHARNTASPTDEHVQL 197
            ..:.:|..::         |.::...:|.:.:|:       ||:.|      ||.:.|..:.:  
Mouse    98 VRLAMEAEKV---------QAAHQWREDFASNEVVYYNAKDDLDPE------RNESEPGSQRI-- 145

  Fly   198 YLNTQIESCQPDYETDLEYGSSSTQSIHYNRQQIQI-----------LNYLKSDDARATFLNENN 251
                     :|.:..|..:|    :.|.|....:.|           ||.|....|.......|.
Mouse   146 ---------KPVFIEDANFG----RQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKRNR 197

  Fly   252 -----------------ARSLAVNGYISNQLVLLKRRLSRSDAENSNSKP--ISGNHFKHIYFLS 297
                             ||....:.::.|     .|..::.|..:...:|  |.|          
Mouse   198 DEDPTLLWQVFGSATGLARYYPASPWVDN-----SRTPNKIDLYDVRRRPWYIQG---------- 247

  Fly   298 NSDGASASLHFRQLYVSAIKQKFVLFLIDVGSALSAELFDLSKSFVHEMLQLLEDTDKVSLVTVA 362
                             |...|.:|.|:||..::|.....|.::.|.|||:.|.|.|   .|.||
Mouse   248 -----------------AASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDD---FVNVA 292

  Fly   363 S-EANFMSLEAFPAEAGHGIYSATRAHKEEIISFINSLSRAQAFTNHSLGFEYSFELLHRLQQSG 426
            | .:|...:..|.    |.:.:..| :|:.:...:|::: |:..|::..||.::||.|       
Mouse   293 SFNSNAQDVSCFQ----HLVQANVR-NKKVLKDAVNNIT-AKGITDYKKGFSFAFEQL------- 344

  Fly   427 MINTAEQPVEFVYITRGLLTNLSDAMA--VLRVVADGQRRLRAPVIINTCAVVLDEKRIMYEKQF 489
                             |..|:|.|..  ::.:..||... ||..|.   |....:|::   :.|
Mouse   345 -----------------LNYNVSRANCNKIIMLFTDGGEE-RAQEIF---AKYNKDKKV---RVF 385

  Fly   490 LNDVASQNYTK--------------YEI-DVASWWPSGQEASELVGRFYVLSKMHAETSLPQTSS 539
            ...|...||.:              ||| .:.:...:.||..:::||..||:...|:        
Mouse   386 TFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAK-------- 442

  Fly   540 RIFGPLFQERYLSDTLEVHPPVVDADSGDVLVSITHAVPPY------------------GVVGVN 586
                            :|....|..|:.::.:.||..:|.:                  ||:||:
Mouse   443 ----------------QVQWTNVYLDALELGLVITGTLPVFNVTGQSENKTNLKNQLILGVMGVD 491

  Fly   587 LYLSDLLEDLLNYPSTTSSAKQGLGYAFLLDRSTGNTLAHP---------AFP-------RPLIQ 635
            :.|.|:......:....:      ||.|.:| ..|..|.||         ..|       ||.:|
Mouse   492 VSLEDIKRLTPRFTLCPN------GYYFAID-PNGYVLLHPNLQPKPIGVGIPTINLRKRRPNVQ 549

  Fly   636 RETSY-PVNIAYL--ENATDFSSHIRDRLLREESGNVTTDVYVGRQ------RLQRTYYWQSVLG 691
            ...|. ||.:.:|  |...:....||::::..|||..|....|..|      :..|||.|..|.|
Mouse   550 NPKSQEPVTLDFLDAELENEIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNG 614

  Fly   692 F-YVLCLV----------SSGGDTLRNVSSTQRYNLKDTVSNYEPGYYGESMDLLYHRLDLNQGG 745
            . |.|.||          :...:|:....| ::..:||: ...:|..:.||            |.
Mouse   615 TDYSLALVLPTYSFYYIKAKLEETITQARS-KKGKMKDS-ETLKPDNFEES------------GY 665

  Fly   746 S--APPKTCRYFRQVATMDAPTLFLSAAAFESPFGFLHNNRPRTQLRHVESIMAYLRDSSGLLAN 808
            :  ||.:.|   ..:...|..|.||  ..|..   |:....|.....:.:.|...|.|:      
Mouse   666 TFIAPREYC---NDLKPSDNNTEFL--LNFNE---FIDRKTPNNPSCNTDLINRILLDA------ 716

  Fly   809 MGLRPSIRHEVGVLYQAMQQLRRRHQDARGSLRSHVIRRYIASVSGVLQLYP---GCLLSSSYDP 870
                       |...:.:|....:.::.:|     |..|::.:..|:.::||   |.....:.:.
Mouse   717 -----------GFTNELVQNYWSKQKNIKG-----VKARFVVTDGGITRVYPKEAGENWQENPET 765

  Fly   871 TRRPWFRQAIAQPGKIVSTAPYLDAGGAGYIITIAHTIFEGKAHALHSAQQDRPVAVVALDVPYA 935
            ....:::::: .....|.||||.:..|.|   .....|...||..|:...:....|||.:.:...
Mouse   766 YEDSFYKRSL-DNDNYVFTAPYFNKSGPG---AYESGIMVSKAVELYIQGKLLKPAVVGIKIDVN 826

  Fly   936 FYYRLILEGT-------PICQLPH----IKCLLFEHEGYLL-----------------AHPSMLQ 972
            .:.....:.:       |:|....    :.|::.:..|:||                 ..|||::
Mouse   827 SWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSMMR 891

  Fly   973 P---------------ATLTKNQRRPHEHLTHKESYLAN--DMLNHG------------QLVRKL 1008
            .               .::......|.:...|:.:|:.:  |:|..|            ||:..|
Mouse   892 HLVNISLYAFNKSYDYQSVCDPGAAPKQGAGHRSAYVPSIADILQIGWWATAAAWSILQQLLLSL 956

  Fly  1009 G---------------CASYQNR---TLQRYYAFNTSLSSILGNVVHGERTK-YAIALIRGSNLF 1054
            .               .||...:   |.|..|.|.....|..|.:..|..:: :.:..:..:||.
Mouse   957 TFPRLLEAVEMEEDDFTASLSKQSCITEQTQYFFKNDTKSFSGLLDCGNCSRIFHVEKLMNTNLV 1021

  Fly  1055 AAVLNSSCDGGAFCPCSTIDRECLNCKRMDQTDCECPCECPMVGDSSSPSSLMYFANYTRQFPYC 1119
            ..::.|.    ..|||.|  |..:   :.:||. :.|..|.||                :|..|.
Mouse  1022 FIMVESK----GTCPCDT--RLLM---QAEQTS-DGPDPCDMV----------------KQPRYR 1060

  Fly  1120 PPPSEHFIALPPTTQLLSTLPNCPGSAGI 1148
            ..|...|     ...:|....:|.|.:|:
Mouse  1061 KGPDVCF-----DNNVLEDYTDCGGVSGL 1084

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG16868NP_611469.1 vWFA 308..>426 CDD:294047 32/118 (27%)
Cache_1 559..627 CDD:280839 17/85 (20%)
Cacna2d1XP_011248046.1 VWA_N 104..223 CDD:369855 22/148 (15%)
vWA_VGCC_like 239..417 CDD:238740 53/244 (22%)
dCache_1 <437..622 CDD:376917 46/215 (21%)
VGCC_alpha2 651..1079 CDD:369894 87/505 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2353
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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