Protein Alignment CG16868 and Cacna2d1

DIOPT Version :10

• Sequence 1: NP_611469.1
• Gene: CG16868 / 37298
• FlyBaseID: FBgn0034498
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: XP_011248046.1
• Gene: Cacna2d1 / 12293
• MGIID: 88295
• Length: 1110
• Species: Mus musculus
• Alignment Length: 1264
• Identity: 243/1264 - (19%)
• Similarity: 419/1264 - (33%)
• Gaps: 416/1264 - (32%)

  Fly    85 VAKIQEIFDSMHFSSAKGASNTRQASS-----NDSNVVNPQLQRDLQLFSER-----LSKKIQKA 139
            |.|:||...::    ||.||...|.:.     .|...|.|...|.|...:.|     ||.:.:..
Mouse    37 VDKMQEDLVTL----AKTASGVTQLADIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKAL 97

  Fly   140 TYVVLELRELLRYNLTKVWQYSYDDEDDESESEM-------DLEMELEDLHARNTASPTDEHVQL 197
            ..:.:|..::         |.::...:|.:.:|:       ||:.|      ||.:.|..:.:
Mouse    98 VRLAMEAEKV---------QAAHQWREDFASNEVVYYNAKDDLDPE------RNESEPGSQRI-- 145

  Fly   198 YLNTQIESCQPDYETDLEYGSSSTQSIHYNRQQIQI-----------LNYLKSDDARATFLNENN 251
                     :|.:..|..:|    :.|.|....:.|           ||.|....|.......|.
Mouse   146 ---------KPVFIEDANFG----RQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKRNR 197

  Fly   252 -----------------ARSLAVNGYISNQLVLLKRRLSRSDAENSNSKP--ISGNHFKHIYFLS 297
                             ||....:.::.|     .|..::.|..:...:|  |.|
Mouse   198 DEDPTLLWQVFGSATGLARYYPASPWVDN-----SRTPNKIDLYDVRRRPWYIQG---------- 247

  Fly   298 NSDGASASLHFRQLYVSAIKQKFVLFLIDVGSALSAELFDLSKSFVHEMLQLLEDTDKVSLVTVA 362
                             |...|.:|.|:||..::|.....|.::.|.|||:.|.|.|   .|.||
Mouse   248 -----------------AASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDD---FVNVA 292

  Fly   363 S-EANFMSLEAFPAEAGHGIYSATRAHKEEIISFINSLSRAQAFTNHSLGFEYSFELLHRLQQSG 426
            | .:|...:..|.    |.:.:..| :|:.:...:|::: |:..|::..||.::||.|
Mouse   293 SFNSNAQDVSCFQ----HLVQANVR-NKKVLKDAVNNIT-AKGITDYKKGFSFAFEQL------- 344

  Fly   427 MINTAEQPVEFVYITRGLLTNLSDAMA--VLRVVADGQRRLRAPVIINTCAVVLDEKRIMYEKQF 489
                             |..|:|.|..  ::.:..||... ||..|.   |....:|::   :.|
Mouse   345 -----------------LNYNVSRANCNKIIMLFTDGGEE-RAQEIF---AKYNKDKKV---RVF 385

  Fly   490 LNDVASQNYTK--------------YEI-DVASWWPSGQEASELVGRFYVLSKMHAETSLPQTSS 539
            ...|...||.:              ||| .:.:...:.||..:::||..||:...|:
Mouse   386 TFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAK-------- 442

  Fly   540 RIFGPLFQERYLSDTLEVHPPVVDADSGDVLVSITHAVPPY------------------GVVGVN 586
                            :|....|..|:.::.:.||..:|.:                  ||:||:
Mouse   443 ----------------QVQWTNVYLDALELGLVITGTLPVFNVTGQSENKTNLKNQLILGVMGVD 491

  Fly   587 LYLSDLLEDLLNYPSTTSSAKQGLGYAFLLDRSTGNTLAHP---------AFP-------RPLIQ 635
            :.|.|:......:....:      ||.|.:| ..|..|.||         ..|       ||.:|
Mouse   492 VSLEDIKRLTPRFTLCPN------GYYFAID-PNGYVLLHPNLQPKPIGVGIPTINLRKRRPNVQ 549

  Fly   636 RETSY-PVNIAYL--ENATDFSSHIRDRLLREESGNVTTDVYVGRQ------RLQRTYYWQSVLG 691
            ...|. ||.:.:|  |...:....||::::..|||..|....|..|      :..|||.|..|.|
Mouse   550 NPKSQEPVTLDFLDAELENEIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNG 614

  Fly   692 F-YVLCLV----------SSGGDTLRNVSSTQRYNLKDTVSNYEPGYYGESMDLLYHRLDLNQGG 745
            . |.|.||          :...:|:....| ::..:||: ...:|..:.||            |.
Mouse   615 TDYSLALVLPTYSFYYIKAKLEETITQARS-KKGKMKDS-ETLKPDNFEES------------GY 665

  Fly   746 S--APPKTCRYFRQVATMDAPTLFLSAAAFESPFGFLHNNRPRTQLRHVESIMAYLRDSSGLLAN 808
            :  ||.:.|   ..:...|..|.||  ..|..   |:....|.....:.:.|...|.|:
Mouse   666 TFIAPREYC---NDLKPSDNNTEFL--LNFNE---FIDRKTPNNPSCNTDLINRILLDA------ 716

  Fly   809 MGLRPSIRHEVGVLYQAMQQLRRRHQDARGSLRSHVIRRYIASVSGVLQLYP---GCLLSSSYDP 870
                       |...:.:|....:.::.:|     |..|::.:..|:.::||   |.....:.:.
Mouse   717 -----------GFTNELVQNYWSKQKNIKG-----VKARFVVTDGGITRVYPKEAGENWQENPET 765

  Fly   871 TRRPWFRQAIAQPGKIVSTAPYLDAGGAGYIITIAHTIFEGKAHALHSAQQDRPVAVVALDVPYA 935
            ....:::::: .....|.||||.:..|.|   .....|...||..|:...:....|||.:.:...
Mouse   766 YEDSFYKRSL-DNDNYVFTAPYFNKSGPG---AYESGIMVSKAVELYIQGKLLKPAVVGIKIDVN 826

  Fly   936 FYYRLILEGT-------PICQLPH----IKCLLFEHEGYLL-----------------AHPSMLQ 972
            .:.....:.:       |:|....    :.|::.:..|:||                 ..|||::
Mouse   827 SWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSMMR 891

  Fly   973 P---------------ATLTKNQRRPHEHLTHKESYLAN--DMLNHG------------QLVRKL 1008
            .               .::......|.:...|:.:|:.:  |:|..|            ||:..|
Mouse   892 HLVNISLYAFNKSYDYQSVCDPGAAPKQGAGHRSAYVPSIADILQIGWWATAAAWSILQQLLLSL 956

  Fly  1009 G---------------CASYQNR---TLQRYYAFNTSLSSILGNVVHGERTK-YAIALIRGSNLF 1054
            .               .||...:   |.|..|.|.....|..|.:..|..:: :.:..:..:||.
Mouse   957 TFPRLLEAVEMEEDDFTASLSKQSCITEQTQYFFKNDTKSFSGLLDCGNCSRIFHVEKLMNTNLV 1021

  Fly  1055 AAVLNSSCDGGAFCPCSTIDRECLNCKRMDQTDCECPCECPMVGDSSSPSSLMYFANYTRQFPYC 1119
            ..::.|.    ..|||.|  |..:   :.:||. :.|..|.||                :|..|.
Mouse  1022 FIMVESK----GTCPCDT--RLLM---QAEQTS-DGPDPCDMV----------------KQPRYR 1060

  Fly  1120 PPPSEHFIALPPTTQLLSTLPNCPGSAGI 1148
            ..|...|     ...:|....:|.|.:|:
Mouse  1061 KGPDVCF-----DNNVLEDYTDCGGVSGL 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16868	NP_611469.1	vWFA	308..>426	CDD:469594	32/118 (27%)
		HK_sensor	<867..933	CDD:365792	14/65 (22%)
Cacna2d1	XP_011248046.1	VWA_N	104..223	CDD:462464	22/148 (15%)
		vWA_VGCC_like	239..417	CDD:238740	53/244 (22%)
		dCache_1	<435..>529	CDD:460673	23/124 (19%)
		VGCC_alpha2	651..1079	CDD:462488	87/505 (17%)