Protein Alignment CG16868 and cachd1

DIOPT Version :9

• Sequence 1: NP_611469.1
• Gene: CG16868 / 37298
• FlyBaseID: FBgn0034498
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: XP_002931660.2
• Gene: cachd1 / 100485053
• XenbaseID: XB-GENE-1010398
• Length: 1276
• Species: Xenopus tropicalis
• Alignment Length: 1416
• Identity: 416/1416 - (29%)
• Similarity: 656/1416 - (46%)
• Gaps: 282/1416 - (19%)

  Fly    98 SSAKGASNTRQASSNDSNVVNPQLQRDLQLFSERLSKKIQKATYVVLELRELLRYNLTKVW-QYS 161
            |||.....|.:|.| :.|::     .:.||.:.::.|         |...||..:::.::: .:.
 Frog    25 SSAVTVWGTARADS-EFNIL-----EEAQLVAAQMKK---------LAAEELGVFSMLRIFNSFV 74

  Fly   162 YDDEDDESESEM-DLEMELE-------DLHARN----TASPTDEHVQLYLNTQIESC----QPDY 210
            |.::....|:|: .|..::.       |:..||    .||.| .|:...| |.|:.|    ....
 Frog    75 YTEKISNGETEVQQLAKKIREKFNRYLDVVTRNKQVVEASYT-AHLTSPL-TAIQDCCTIPASMM 137

  Fly   211 ETDLEYGSSSTQSIHYNRQQIQILNYLKSDDARATFLNE---NNARSLAVNGYISNQLVLLKRRL 272
            |.|..:.::.:::|              |.|..:|.:|.   |..|.|       |.::
 Frog   138 EFDGNFNTNVSRTI--------------SCDRLSTTVNSRAFNPGRDL-------NSVL------ 175

  Fly   273 SRSDAENSNSKPISGNHFKHIYFLSNSDG-------------ASASLHFRQLYVSAIK--QKFVL 322
                |:|..|.|    ..|..|| |:.:|             :|.....|.:|||.::  .|.::
 Frog   176 ----ADNLKSNP----GIKWQYF-SSEEGIFTVFPAHKFRCKSSYEHRSRPVYVSTVRPQSKHIV 231

  Fly   323 FLIDVGSALSAELFDLSKSFVHEMLQLLEDTDKVSLVTVASEANFMSLE----AFPAEAGHGIYS 383
            .::|.|::::.....:::.....:|..:::.||:|::|||......||:    .|       :..
 Frog   232 VIMDHGASITETQLQIARDATLVILNSIDEHDKISVLTVADIGRTCSLDPCYKTF-------LSP 289

  Fly   384 ATRAHKEEIISFINSLSRAQAFTNHSLGFEYSFELLHRLQQSGMINTAEQPVEFVYITRGLLTNL 448
            ||...|.|:.||::|:..:.:.|.|:|||:.:|:|:...:....|: |...:..:|::.|:.:..
 Frog   290 ATSEAKREMASFVSSVKSSDSPTQHALGFQKAFQLIRNTKNGTKIH-ANTDIVIIYLSAGITSKD 353

  Fly   449 S---DAMAVLRVVADGQRRLRAPVIINTCAVVLDEKRIMYEKQFLNDVASQNYTKYEIDVASWWP 510
            |   |..|.|||:::....:...|:|.|.|::.:....:.|..||.|:|.||..||.:...:..|
 Frog   354 SSEEDKKATLRVISEENSLMNNSVMILTYAIMNEGVTGLKELAFLRDLAEQNSAKYGVSDKTGLP 418

  Fly   511 ------------SGQEASELVGRFYVLSKMHAETSLPQTSSRIFGPLFQERYLSDTLEVHPPVVD 563
                        |..|.:  |||||        |:||..             :.|......|..|
 Frog   419 VTKGSMMVLNQLSNLETT--VGRFY--------TNLPNR-------------MIDEAVFSLPFTD 460

  Fly   564 ADSGDVLVSITHAVPPY------GVVGVNLYLSDLLEDLLNYPSTTSSAKQGLGYAFLLDRSTGN 622
             :.||.|: :|.:.|.|      |:|||::.|:.:|||:..|..:.:|      |.||:| :.|.
 Frog   461 -EMGDGLI-MTVSKPCYFGNLLLGIVGVDVNLAYILEDVTYYQDSLAS------YTFLID-NKGY 516

  Fly   623 TLAHPAFPRPLIQRETSYPVNIAYLENATDFSSHIRDRLLREESGNVTTDVYV------------ 675
            ||.||:..||.:..|.....:|.:.||...|:. :|..:|....|:....|.|
 Frog   517 TLMHPSLTRPYLLVEPPLHTDIIHYENIPKFAL-VRQNILSLPLGSQIITVPVNSSLSWHINKLR 580

  Fly   676 --GRQRLQRTYYWQSVLG-FYVLCLVSSGGDTLRNVSSTQRYNLKDTVSNYEPGYYGESMDLLYH 737
              |:.....:|.|:.|.. .::||:|....:    :...|..|| :||         .|..||||
 Frog   581 DPGKDAYNVSYAWKMVQDTSFILCIVVIQPE----IPVKQLKNL-NTV---------PSSKLLYH 631

  Fly   738 RLDLNQGGSAPPKTCRYFRQVATMDAPTLFLSAAAFESPFGFLHNNRPRTQLRHVESIMAYLRDS 802
            ||||    ...|..|.:|:|:||:::||:.|:|.:|.||:.  |.::|.|: |.||...|||.|:
 Frog   632 RLDL----LGQPSACLHFKQLATLESPTVMLAAGSFSSPYE--HLSQPETK-RMVEHYTAYLSDN 689

  Fly   803 SGLLANMGLRPSIRHEV----GVLYQAMQQLRRRHQDARGSLRSHVIRRYIASVSGVLQLYPGCL 863
            :.|:||.||:.|:|:||    .|..:.|.|:.      ..||.|:::|||||:.:|||::|||.|
 Frog   690 TRLIANPGLKFSVRNEVMATSHVTDEWMTQME------MSSLNSYIVRRYIATPNGVLRIYPGSL 748

  Fly   864 LSSSYDPTRRPWFRQAIAQPGKIVSTAPYLDAGGAGYIITIAHTIFEGKAHALHSAQQDRP---V 925
            :..::|||||.|:..|:|.||.|..|.||||.|||||::||:|||     |:  |:.|..|   |
 Frog   749 MDKAFDPTRRQWYLHALANPGLITFTGPYLDVGGAGYVVTISHTI-----HS--SSSQISPGNTV 806

  Fly   926 AVVALDVPYAFYYRLILEGTPICQLP---HIKCLLFEHEGYLLAHPSMLQPATLTKNQRRPH--- 984
            ||:.:|....::|::::|..|:|...   .|:|.:.|..|||:|||:::.|        :.|
 Frog   807 AVMGIDFTLRYFYKVLMELLPVCNQDGGNKIRCFIMEDRGYLVAHPTLIDP--------KGHAPV 863

  Fly   985 --EHLTHKESYLANDMLNHGQLVRKLGCASYQNRTLQRYYAFNTSLSSILGNVVHGER-TKYAIA 1046
              :|:||||..:|||:|||...|:|..|.|:.:||:||:|.|||||...|.|:|||.. :||.:.
 Frog   864 EQQHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQRFYKFNTSLVGDLTNLVHGSHCSKYRLT 928

  Fly  1047 LIRGSNLFAAVLNSSCDGGAFCPCSTIDRECLNCKRMDQTDCECPCECPMVGDSSSPSSLMYFAN 1111
            .:.|:|.|..::|.:||..|||.||.:||.||||.||:|.:||||||||:..:..:.:    ..|
 Frog   929 RVPGTNAFVGIVNETCDSLAFCACSMVDRLCLNCHRMEQNECECPCECPLEVNECTGN----LTN 989

  Fly  1112 YTRQFPYCPPPSE--HFIALPPTTQLLSTLPNCPGSAGICETYSTQR----ECLGVMGCEWCQLD 1170
            ...:.|.|....|  .|..|.|:.|  ..|..|      ..|..|||    .|.||:.||||.:|
 Frog   990 AESRNPSCEVHQEPMTFTMLDPSLQ--DALFQC------VNTGCTQRMESSYCFGVLDCEWCMVD 1046

  Fly  1171 VDGNS-FSTSFCSSQASCFNGVLASLTPYGELDEMELLAAHNPQREQHAYSAFGPLGGAIVVLVM 1234
            .||.: ....:|:.|..||.|::.:.:||.  |:|..:............:..||:.|.|:..:|
 Frog  1047 SDGKTHLDKPYCALQKECFGGIVGAKSPYA--DDMSSIGDEVITLNMIKSAPVGPVAGGIMGCIM 1109

  Fly  1235 VIGFAIYCYRHNLDAQTQEHFYVDSVQEENYGLPLSRFNFDDCKAHDEPPLGGGYDHASAQRQLM 1299
            |:..|:|.|||.:..::.:|....:.||  ..:.:|....|    .||.......|.........
 Frog  1110 VLVLAVYAYRHQIHRRSHQHMSPLAAQE--MSVRMSNLEND----RDERDEDSHEDRGIISNTRF 1168

  Fly  1300 HAADISPYHVSSGSSYRR---PPNGESDHGYSTMTPHEDSSDQQCFTLAEPLLLHDKRHSKSDTM 1361
            .||.|. .|..|....||   ....|||||||||:|.|||.:..|               .:|.:
 Frog  1169 IAAVIE-RHAHSPERRRRYWGRSGTESDHGYSTMSPQEDSENPPC---------------NNDPL 1217

  Fly  1362 SISTSISSPTNRQQSSSQPNT---------HPYLSNQPTSKTERYKQVQAT 1403
            |....:.:.....:..:.|.|         |.|..:.|......:.|...|
 Frog  1218 SAGVDVGNHDEDLEPDTPPQTAALLSHKFHHHYRLHHPALHHSHHLQAAVT 1268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16868	NP_611469.1	vWFA	308..>426	CDD:294047	31/123 (25%)
		Cache_1	559..627	CDD:280839	25/73 (34%)
cachd1	XP_002931660.2	VWA_N	90..205	CDD:369855	31/152 (20%)
		vWFA	214..>331	CDD:381780	31/123 (25%)
		HK_sensor	<450..490	CDD:365792	13/41 (32%)
		dCache_1	675..>852	CDD:376917	80/190 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	497	1.000	Domainoid score	I363
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10854
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1349
OMA	1	1.010	-	-		QHG50145
OrthoDB	1	1.010	-	-		D137593at33208
OrthoFinder	1	1.000	-	-		FOG0006978
OrthoInspector	1	1.000	-	-		oto102509
Panther	1	1.100	-	-	LDO	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5065
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.080