DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9143 and MAK5

DIOPT Version :9

Sequence 1:	NP_611467.1	Gene:	CG9143 / 37296	FlyBaseID:	FBgn0034496	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_009700.1	Gene:	MAK5 / 852439	SGDID:	S000000346	Length:	773	Species:	Saccharomyces cerevisiae

Alignment Length:	892	Identity:	259/892 - (29%)
Similarity:	409/892 - (45%)	Gaps:	209/892 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QNKQKTAKPPKLLKGAAKEPALSKAENWQKVKIKGHVISDDGGGFEGLIGLEVLKDYDASLVKSS 67
            |..:...||.:::...:|       .||:.|.|...:  ||.|||   .|||.:...|..:|...
Yeast     8 QKGKTVTKPQEIIVDESK-------LNWKPVDIPDTL--DDFGGF---YGLEEIDGVDVKVVDGK 60

  Fly    68 QKRTTSRNPDRERKLKKKKRKVSKGDEEESSESSSESESEDEVAVAARTSKKARLAERHAQKMQK 132
            ....|.    ::.|:.|...|...||::||.|:.|.|:||.|:.                 :.:.
Yeast    61 VTFVTK----KDSKVLKDSNKEKVGDDQESVENESGSDSESELL-----------------EFKN 104

  Fly   133 LREKREKRKELRKQKKSKGKENDNSEESSDEHAADRFALLRPPPSDDEEEV---VKAEDSADQQE 194
            |.:.:|..........|...|..|.|.|.          |..|..|.:|:|   |..|:..::..
Yeast   105 LDDIKEGELSAASYSSSDEDEQGNIESSK----------LTDPSEDVDEDVDEDVLKENVFNKDI 159

  Fly   195 STDEEAPELVPISTGEAEDMSAWNGLG-VPASILRALGEQGFKTPTQIQALTLPAAIHGKKDILG 258
            :.|:.:|..:|          .|..|. :..:||::|....|..||:||..::|..:.| .|::|
Yeast   160 NIDDISPVNLP----------EWTNLAPLSMTILQSLQNLNFLRPTEIQKKSIPVIMQG-VDVMG 213

  Fly   259 AAETGSGKTLAFGIPMLAGIMELKQRNIRSGIRKAPKVKGQQPEPAADEHELTPPPEELDHVSGA 323
            .|.||||||||:|||::                                       |:|  :|..
Yeast   214 KASTGSGKTLAYGIPIV---------------------------------------EKL--ISNF 237

  Fly   324 SDEESDAEEQAQRVQTPLYGLVLTPTRELAVQVKNHL-------VAAAKYTGIRVAAIFGGLAVA 381
            |          |:.:.|: .|:.|||||||.||.:||       :|.::|:   :.::.|||::.
Yeast   238 S----------QKNKKPI-SLIFTPTRELAHQVTDHLKKICEPVLAKSQYS---ILSLTGGLSIQ 288

  Fly   382 KQERVLR--QCPDIVVATPGRLWELYAQGNRHLGKIEDVSFLVIDETDRMVEKGHFEELRSLLKV 444
            ||:|:|:  ....||:|||||..||..:.|..:.:...|:.|::||.||:::.|||:|...::|.
Yeast   289 KQQRLLKYDNSGQIVIATPGRFLELLEKDNTLIKRFSKVNTLILDEADRLLQDGHFDEFEKIIKH 353

  Fly   445 LNSDEQKKHQR--------QNFVYSATLTLVHDLPDHMQKRNVGKRPKFVKQTVDQ---KIESLI 498
            |..:.:|..:.        |..::|||.::  ||.|.:......|..:| |...|:   .|:.|:
Yeast   354 LLVERRKNRENSEGSSKIWQTLIFSATFSI--DLFDKLSSSRQVKDRRF-KNNEDELNAVIQHLM 415

  Fly   499 EELGI-SQPKIVDITSSQQTAQTLTESRLLCPIDHKDYHLYYFIQRHPGRTIVFCNSIDCVKRLA 562
            .::.. |:|.|:|.....:.:..:.||.:.||...:|.:.|||:...||.|::|||:||.||:|.
Yeast   416 SKIHFNSKPVIIDTNPESKVSSQIKESLIECPPLERDLYCYYFLTMFPGTTLIFCNAIDSVKKLT 480

  Fly   563 TLFGLLDCNPLPLHANMIQKQRLKNLERFRDSP----------------TGLLIATDVAARGLDI 611
            .....|......:|::|.||.|||:||||:...                :.:|||:|||||||||
Yeast   481 VYLNNLGIPAFQIHSSMTQKNRLKSLERFKQQSAKQKTINHSNPDSVQLSTVLIASDVAARGLDI 545

  Fly   612 PNVEHVIHYQVPRTSENYVHRSGRTARANKHGITVMFMEPGEVKSYV-KLYKTLER----TEDL- 670
            |.|:|||||.:||:::.|:|||||||||...|::.|...|.|....: ||.|||..    :.||
Yeast   546 PGVQHVIHYHLPRSTDIYIHRSGRTARAGSEGVSAMICSPQESMGPLRKLRKTLATKNSVSTDLN 610

  Fly   671 ---------------PLFPILERFMGAVRERVNLARDLDKEELKLKRVQSERGWMKKHAEEMDMI 720
                           ||.||....:..:|||..||.:|...|:....::.:..|:||.|:|:.:.
Yeast   611 SRSTNRKPIKWQNTVPLLPIETDILSQLRERSRLAGELADHEIASNSLRKDDNWLKKAADELGID 675

  Fly   721 IDGYNDESGSDQDEDPFVIERRR-------NRLRVETVRAQLNALLAQPIFPRGFSFKYPNSEAA 778
            :|...|:. |..:.|.|:::.:.       |:.:|:.:||.||.||:.|| .:....||......
Yeast   676 VDSDEDDI-SKSNSDTFLLKNKNKKMQKTINKDKVKAMRATLNELLSVPI-RKDRRQKYLTGGLV 738

  Fly   779 QLATS------------HTQ-SAVETMKAAIEDQKQAKKDRNKRKRN 812
            .||.:            |.: :|:||:|             .|:|||
Yeast   739 NLADNLVKKRGHNSIIGHEKTNALETLK-------------KKKKRN 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9143	NP_611467.1	BLVR	<125..191	CDD:283923	14/68 (21%)
		SrmB	201..747	CDD:223587	190/611 (31%)
		P-loop_NTPase	217..465	CDD:304359	80/265 (30%)
		HELICc	531..648	CDD:238034	59/132 (45%)
MAK5	NP_009700.1	SrmB	151..729	CDD:223587	201/648 (31%)
MAK5	NP_009700.1	DEADc_DDX24	182..428	CDD:350704	90/304 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344334
Domainoid	1	1.000	115	1.000	Domainoid score	I1321
eggNOG	1	0.900	-	-		E2759_KOG0347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	299	1.000	Inparanoid score	I507
Isobase	1	0.950	-	0	Normalized mean entropy	S2436
OMA	1	1.010	-	-		QHG53695
OrthoFinder	1	1.000	-	-		FOG0004383
OrthoInspector	1	1.000	-	-		oto99751
orthoMCL	1	0.900	-	-		OOG6_102605
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R679
SonicParanoid	1	1.000	-	-		X3667
TreeFam	1	0.960	-	-
	15	14.740