Protein Alignment CG9143 and DDX24

DIOPT Version :10

• Sequence 1: NP_611467.1
• Gene: CG9143 / 37296
• FlyBaseID: FBgn0287774
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_065147.1
• Gene: DDX24 / 57062
• HGNCID: 13266
• Length: 859
• Species: Homo sapiens
• Alignment Length: 907
• Identity: 327/907 - (36%)
• Similarity: 477/907 - (52%)
• Gaps: 166/907 - (18%)

  Fly     5 KQKTAKPPKLLKGAAKEPALSKAENWQKVKIKGHVISDDGGGFEGLIGLEVLKDYDASLVKSSQK 69
            |...::|.:...|..:...:.....|::|||..::.:|  |..:.|:..|.|.||        |.
Human     4 KDTKSRPKQSSCGKFQTKGIKVVGKWKEVKIDPNMFAD--GQMDDLVCFEELTDY--------QL 58

  Fly    70 RTTSRNPD---RERKLKKKKRKVSKGDEEESSESSSESESEDEVAVAARTSKKARLAERHAQKMQ 131
            .:.::||.   .:...|:|.:.||:.:|||..:|||..:.     :..:.||.........||
Human    59 VSPAKNPSSLFSKEAPKRKAQAVSEEEEEEEGKSSSPKKK-----IKLKKSKNVATEGTSTQK-- 116

  Fly   132 KLREKREKRKELRKQKKSKGKENDNSEESSDEHAADRFALLRPPPSDDEEEVVKAEDSADQQEST 196
               |...|..||..|......::..:.|.:.|:      |::..|...:.   |.:...:..:||
Human   117 ---EFEVKDPELEAQGDDMVCDDPEAGEMTSEN------LVQTAPKKKKN---KGKKGLEPSQST 169

  Fly   197 DEEAPE----LVPISTGEAEDMSAWNGLGVPASILRALGEQGFKTPTQIQALTLPAAIHGKKDIL 257
            ..:.|:    .:|....:..|:|||..|.||..:||||...||..||.||||||..||..|.|||
Human   170 AAKVPKKAKTWIPEVHDQKADVSAWKDLFVPRPVLRALSFLGFSAPTPIQALTLAPAIRDKLDIL 234

  Fly   258 GAAETGSGKTLAFGIPMLAGIMELKQRNIRSGIRKAPKVKGQQPEPAADEHELTPPPEELDHVSG 322
            |||||||||||||.|||:..:::.::||             ..|.|:..|    .||.|....:|
Human   235 GAAETGSGKTLAFAIPMIHAVLQWQKRN-------------AAPPPSNTE----APPGETRTEAG 282

  Fly   323 A-------SDEESDA-------------------------------------------------- 330
            |       ::.||||
Human   283 AETRSPGKAEAESDALPDDTVIESEALPSDIAAEARAKTGGTVSDQALLFGDDDAGEGPSSLIRE 347

  Fly   331 ----------EEQAQRVQT--------------------PLYGLVLTPTRELAVQVKNHLVAAAK 365
                      ||...:.||                    ||.|||||||||||||||.|:.|.|:
Human   348 KPVPKQNENEEENLDKEQTGNLKQELDDKSATCKAYPKRPLLGLVLTPTRELAVQVKQHIDAVAR 412

  Fly   366 YTGIRVAAIFGGLAVAKQERVLRQCPDIVVATPGRLWELYAQGNRHLGKIEDVSFLVIDETDRMV 430
            :|||:.|.:.||::..||:|:|.:.|:||||||||||||..:.:.||..:..:..||:||.||||
Human   413 FTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHYHLRNLRQLRCLVVDEADRMV 477

  Fly   431 EKGHFEELRSLLKVLNSDEQKKHQRQNFVYSATLTLVHDLPDH-MQKRNVGKRPKFVKQTVDQKI 494
            |||||.||..||::|| |.|...:||..|:||||||||..|.. :.|::..|..|      ..|:
Human   478 EKGHFAELSQLLEMLN-DSQYNPKRQTLVFSATLTLVHQAPARILHKKHTKKMDK------TAKL 535

  Fly   495 ESLIEELGI-SQPKIVDITSSQQTAQTLTESRLLCPIDHKDYHLYYFIQRHPGRTIVFCNSIDCV 558
            :.|::::|: .:||::|:|.::.|.:||||:::.|..|.||::||||:.::|||::||.|||.|:
Human   536 DLLMQKIGMRGKPKVIDLTRNEATVETLTETKIHCETDEKDFYLYYFLMQYPGRSLVFANSISCI 600

  Fly   559 KRLATLFGLLDCNPLPLHANMIQKQRLKNLERFRDSPTGLLIATDVAARGLDIPNVEHVIHYQVP 623
            |||:.|..:||..||.|||.|.|||||:|||:|......:|:||||||||||||.|:||||||||
Human   601 KRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQVP 665

  Fly   624 RTSENYVHRSGRTARANKHGITVMFMEPGEVKSYVKLYKTLERTEDLPLFPILERFMGAVRERVN 688
            ||||.|||||||||||...|:::|.:.|.:|.::.|:||||::.||:||||:..::|..|:||:.
Human   666 RTSEIYVHRSGRTARATNEGLSLMLIGPEDVINFKKIYKTLKKDEDIPLFPVQTKYMDVVKERIR 730

  Fly   689 LARDLDKEELKLKRVQSERGWMKKHAEEMDMIIDGYNDESG-SDQDEDPFVIERRRNRLRVETVR 752
            |||.::|.|.:..:......|:::.|..:::.::....:.| :||.|     ||||.: :::.::
Human   731 LARQIEKSEYRNFQACLHNSWIEQAAAALEIELEEDMYKGGKADQQE-----ERRRQK-QMKVLK 789

  Fly   753 AQLNALLAQPIFPRGFSFKYPNSEAAQ----LATSHTQSAVETMKAAIEDQKQAKKDRNKRK 810
            .:|..||:||:|......|||......    .|.|.::||:..:      .||.||...|.|
Human   790 KELRHLLSQPLFTESQKTKYPTQSGKPPLLVSAPSKSESALSCL------SKQKKKKTKKPK 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9143	NP_611467.1	DEADc_DDX24	226..510	CDD:350704	140/372 (38%)
		SF2_C_DEAD	521..648	CDD:350174	79/126 (63%)
DDX24	NP_065147.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	61..170		27/127 (21%)
		Q motif	192..220		15/27 (56%)
		DEADc_DDX24	203..552	CDD:350704	140/372 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..300		13/54 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	326..376		4/49 (8%)
		DEAD box	471..474		2/2 (100%)
		SF2_C_DEAD	563..691	CDD:350174	80/127 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	799..859		15/53 (28%)