DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9143 and pit

DIOPT Version :9

Sequence 1:	NP_611467.1	Gene:	CG9143 / 37296	FlyBaseID:	FBgn0034496	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster

Alignment Length:	769	Identity:	193/769 - (25%)
Similarity:	310/769 - (40%)	Gaps:	222/769 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 RERKLKKK--KRKVSKGDEEESSESSSESESEDEVAVAARTSKK-ARLAERHAQKMQ-------- 131
            ||:.|.||  ||:..|.:..:...:.:..:.|.......:.||| .:|:::|..|.:
  Fly     4 REKLLMKKIVKREKMKKELSQKKGNKNAQKQEPPKQNGNKPSKKPEKLSKKHVAKDEDDDLEEDF 68

  Fly   132 ---KLREKREKRKELRKQKKSKGKENDNSEESSDEHAADRFALLRPPPSDDEEEVVKAEDSADQQ 193
               .|.:|:::::..:||:......:..|::...|..||..:.|......|||:|....:..|||
  Fly    69 QEAPLPKKKQQKQPPKKQQIQVANSDSESDDDEQEDEADEDSDLDEVAEVDEEDVDSGSEDDDQQ 133

  Fly   194 ESTDEEAP------ELVP-------------------------ISTGEAEDMSAWNGLG-VPASI 226
            |..|||.|      :|:|                         :...:::|.|..:..| |..:.
  Fly   134 EDEDEEEPVPAKKTKLLPNKSKAQNGKPAKDDEPFTVESSLAALDYRDSDDRSFASLKGAVSEAT 198

  Fly   227 LRALGEQGFKTPTQIQALTLPAAIHGKKDILGAAETGSGKTLAFGIPMLAGIMELK--QRNIRSG 289
            |||:.|.||...|:||:.:|...:.| :|::|||:|||||||||.||.:..|.:|:  .|| .:|
  Fly   199 LRAIKEMGFTEMTEIQSKSLTPLLKG-RDLVGAAQTGSGKTLAFLIPAVELINKLRFMPRN-GTG 261

  Fly   290 IRKAPKVKGQQPEPAADEHELTPPPEELDHVSGASDEESDAEEQAQRVQTPLYGLVLTPTRELAV 354
            :                                                     ::::|||||::
  Fly   262 V-----------------------------------------------------IIISPTRELSM 273

  Fly   355 Q---VKNHLVAAAKYTGIRVAAIFGGLAVAKQERVLRQCPDIVVATPGRLWELYAQGNRHLGKIE 416
            |   |...|:|...:|   ...:.||.....:...|.:..:|:|||||||.:       ||....
  Fly   274 QTFGVLKELMAHHHHT---YGLVMGGSNRQVESEKLGKGINILVATPGRLLD-------HLQNSP 328

  Fly   417 DVSF-----LVIDETDRMVEKGHFEELRSLLKVLNSDEQKKHQRQNFVYSATLTLVHDLPDHMQK 476
            |..:     |:|||.||::|.|..|||:.::.:|      ..:||..::|||.|
  Fly   329 DFLYKNLQCLIIDEVDRILEIGFEEELKQIINLL------PKRRQTMLFSATQT----------- 376

  Fly   477 RNVGKRPKFVKQTVDQKIESLIEELGISQPKIVDITSSQQTAQT--LTESRLLCPIDHKDYHLYY 539
                           .:||:|.:....|:|..|.:..:|.||..  |.:..::||.:.:...|:.
  Fly   377 ---------------ARIEALSKLALKSEPIYVGVHDNQDTATVDGLEQGYIVCPSEKRLLVLFT 426

  Fly   540 FIQRH-PGRTIVFCNSIDCVKRLATLFGLLDCNPLPLHANMIQKQRLKNLERFRDSPTGLLIATD 603
            |:::: ..:.:||.:|...||....||..:|.....:|....|.:|.....:|.::.:|:|:.||
  Fly   427 FLKKNRKKKVMVFFSSCMSVKYHHELFNYIDLPVTSIHGKQKQTKRTTTFFQFCNAESGILLCTD 491

  Fly   604 VAARGLDIPNVEHVIHYQVPRTSENYVHRSGRTAR-ANKHGITVMFMEPGEV------------- 654
            |||||||||.|:.::.|..|.....|:||.||||| :...|..::.|.|.|:
  Fly   492 VAARGLDIPQVDWIVQYDPPDDPREYIHRVGRTARGSGTSGHALLLMRPEELGFLRYLKAAKVPL 556

  Fly   655 -----------------------------------KSYVKLY-----KTLERTEDLPLFPILERF 679
                                               ||||:.|     |.:.....|.|..:.:.|
  Fly   557 NEFEFSWQKIADIQLQLEKLIAKNYFLNQSAKEAFKSYVRAYDSHQLKQIFNVNTLDLQAVAKSF 621

  Fly   680 MGAVRERVNLARDLDKEELKLKRVQSER-GWMKKHAEEMDMIIDGYNDESGSDQ 732
            ...|...|:|.....|.|...|||.... |:.||           .|:.|.|.|
  Fly   622 GFLVPPVVDLKVGAAKRERPEKRVGGGGFGFYKK-----------MNEGSASKQ 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9143	NP_611467.1	BLVR	<125..191	CDD:283923	15/76 (20%)
		SrmB	201..747	CDD:223587	158/632 (25%)
		P-loop_NTPase	217..465	CDD:304359	74/258 (29%)
		HELICc	531..648	CDD:238034	39/118 (33%)
pit	NP_001287459.1	SrmB	186..677	CDD:223587	154/587 (26%)
		DEADc	187..394	CDD:238167	80/303 (26%)
		HELICc	408..537	CDD:238034	42/128 (33%)
		DUF4217	569..627	CDD:290667	10/57 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451548
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950