DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10444 and slc5a6b

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_005158632.1	Gene:	slc5a6b / 796312	ZFINID:	ZDB-GENE-050913-86	Length:	603	Species:	Danio rerio

Alignment Length:	610	Identity:	241/610 - (39%)
Similarity:	355/610 - (58%)	Gaps:	53/610 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PVG--TFDAWDAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSA 64
            |.|  .|...|..:...:||.|..||:||.:|||:|.||||:|:||:||...|:|.||||:|.||
Zfish     3 PAGHKYFTVIDYVIFGLLLVASMSIGLYYAFTGGRQSTTQEFLIADRSMKCLPLSLSLMATFQSA 67

  Fly    65 ISLMGVSNESYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLSASL 129
            ::::|...|.|..||.:..|..:|||...|.|:.|:|:|||:..||||:|||.||.:|.|:..::
Zfish    68 VAIIGTPAEVYAHGTQYWFIGCSYVLGLLIPAHIFIPLFYRLHLTSVYQYLELRFCKAVRICGTV 132

  Fly   130 AFTVQMVLYMGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQSFLMFA 194
            .|..|||:|||:.:|.|||||.||||.|...|::..|||||.|:.|||||||:.|||||:.:||.
Zfish   133 TFIFQMVIYMGVGIYTPALALNAVTGFHLWGAVLATGLVCTLYTALGGLKAVVWTDVFQTVVMFT 197

  Fly   195 AIYAVIAVSAIKAGGFAAIWDVAVERGRVNFIEFSLDPTVRHTWWSLIIGGMVTYLSLYGVNQTQ 259
            ...|||.|...:|||.:..|....:.||::.|:.:.|||||||:|:|.:||:...||||||||.|
Zfish   198 GQLAVIIVGVHQAGGLSEAWGKVRDGGRISGIDLNPDPTVRHTFWTLAVGGVFLMLSLYGVNQAQ 262

  Fly   260 VQRLLSVRNLKSAQSALWWNLPILGMLSFSTIFSGLSIFYYYRDCDPLLKGRIDKRDQIMPLFAL 324
            |||.||.|..:.|..:.:...|.|.:....:...||.:|..|....|:.:..|..:||::..|.:
Zfish   263 VQRYLSSRTEREAVMSCYMVFPCLQLALLLSCLMGLVMFACYGQNSPVEQQYITSKDQMVLYFVM 327

  Fly   325 ETMGQYPGLCGLFVSGIFSASLSTISSAVTSLSAVTLEDYLKPLYKAIFKRTLIDSKSTMPTKIV 389
            :.:..:|||.||||:.:|||||||||||..||:.||:.|.:||.|      ::.::::|:.:|::
Zfish   328 DMLQNFPGLPGLFVACLFSASLSTISSAFNSLATVTMVDLIKPHY------SMTEARATLLSKLL 386

  Fly   390 ACIFGLLCIGLAFVAGSM-GGVLQASLTIFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIV 453
            |..:|::|:.:|::...| ..||||:|:|||::|||||.:|.||:....:|..|.:.|....|::
Zfish   387 ALSYGIICLAMAYLVHLMNSSVLQAALSIFGMIGGPLLGLFCLGIFFPCANSIGAVTGLSAGLLM 451

  Fly   454 SFWMGFGG---PKPKPV-TLEFSTAG----CENATAVMARAIELSSKSSGVVIEPDYFWLYRISY 510
            :||:|.||   ..|.|| .|..||..    .||.||..|. :|..|:|:|:      ...|.:||
Zfish   452 AFWVGIGGFLTRMPSPVIPLLNSTITVPDVSENITAATAE-LEADSRSAGL------HGFYSLSY 509

  Fly   511 LWLSVIGFLIAVVVGYFSSIVLAHCGKAEN------------AEIYLDKS--------RKQLDYD 555
            :|.|.:.....::||...|.:.... |.::            |:.||..|        .||:|
Zfish   510 MWYSALSSCTVLIVGLIISCITGPT-KGDDVASGTVYPVVKTAQSYLKPSTCCKTTAEHKQVD-- 571

  Fly   556 LFAPMLSRRWRRHKEEQDQTAQDET 580
                  .::......::|..:|:||
Zfish   572 ------GQKEMNGTVKEDAGSQEET 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	226/530 (43%)
slc5a6b	XP_005158632.1	SLC5-6-like_sbd	9..532	CDD:294310	227/535 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596891
Domainoid	1	1.000	358	1.000	Domainoid score	I922
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1798
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D327628at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm6386
orthoMCL	1	0.900	-	-		OOG6_101204
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.760