Protein Alignment CG10444 and SLC5A2

DIOPT Version :9

• Sequence 1: NP_611465.2
• Gene: CG10444 / 37294
• FlyBaseID: FBgn0034494
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: XP_006721135.2
• Gene: SLC5A2 / 6524
• HGNCID: 11037
• Length: 705
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 135/633 - (21%)
• Similarity: 259/633 - (40%)
• Gaps: 151/633 - (23%)

  Fly    17 ILVISA----LIGI-YYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSA---ISLMGVSNE 73
            ||||:|    :||: .:......:.|...|.:|.:||..:||..||.||.:.:   :.|.|....
Human    33 ILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAA 97

  Fly    74 S------YEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRF-GQATRLSASLAF 131
            |      :|:..:|.|:         :..:.|.||:......::.:||.:|| |:..||..|:
Human    98 SGLAVAGFEWNALFVVL---------LLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSV-- 151

  Fly   132 TVQMVLY----MGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQSFLM 192
             :.:.||    :.:.:::.|:.::...|.:...:::.:..:...|:..|||.|::.||..|:|::
Human   152 -LSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVI 215

  Fly   193 FAAIYAVIAVSAIKAGGFAAIWDVAVERGRVNFIEFSLDPTV------------------RH--- 236
            ......::..:..:.||::.::|..:  |....:..|.||.|                  ||
Human   216 LGGACILMGYAFHEVGGYSGLFDKYL--GAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVT 278

  Fly   237 ---TWWSLIIGGMVTYLSLYGVNQTQVQRLLSVRNLKSAQSALWWNLPILGMLSFSTIFSGLSIF 298
               .|.:|::|..:.....:..:|..|||.|:.::|...::    ...:.|.|..:.:|  |.:.
Human   279 GDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKA----GCILCGYLKLTPMF--LMVM 337

  Fly   299 YYYRDCDPLLKGRIDKRDQ---IMPLFALETMG--------QYP---------GLCGLFVSGIFS 343
                   |.:..||...|:   ::|.......|        .||         ||.||.::.:.:
Human   338 -------PGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLA 395

  Fly   344 ASLSTISSAVTSLSAV-TLEDYLKPLYKAIFKRTLIDSKSTMPTKIVACIFGLLCIGLAFVAGSM 407
            |.:|:::|...|.|.: |::.|.:...:|..:..|:..:..:...:|..:     ..|..|..:.
Human   396 ALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSV-----AWLPVVQAAQ 455

  Fly   408 GGVL----QASLTIFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVSFWMGFGGPKPKPVT 468
            ||.|    ||   :...:..|:.|:|.|.:...|.|::|...|.:..|:    ||
Human   456 GGQLFDYIQA---VSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLL----MG---------- 503

  Fly   469 LEFSTAGCENATAVMARAIELSSKSSGVVIEPDY--FWLYRISYLWLSVIGFLIAVVVGYFSSIV 531
                          :||.|...|..||..::|..  .:|..:.||:.:::.|..:.::    ::.
Human   504 --------------LARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL----TLT 550

  Fly   532 LAHCGKAENAEIYLDKSRKQLDYDLFAPMLSRRWRRHKEEQDQTAQDE 579
            ::.|    .|.|    .||.|...:|:      .|..|||::....||
Human   551 VSLC----TAPI----PRKHLHRLVFS------LRHSKEEREDLDADE 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	122/583 (21%)
SLC5A2	XP_006721135.2	SLC5sbd_SGLT2	31..705	CDD:212056	135/633 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810