DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10444 and Slc5a2

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_072112.2	Gene:	Slc5a2 / 64522	RGDID:	620217	Length:	670	Species:	Rattus norvegicus

Alignment Length:	622	Identity:	136/622 - (21%)
Similarity:	256/622 - (41%)	Gaps:	129/622 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ILVISA----LIGI----YYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSA---ISLMGV 70
            ||||:|    :||:    .:|...|   |...|.:|.:||..:||..||.||.:.:   :.|.|.
  Rat    24 ILVIAAYFLLVIGVGLWSMFRTNRG---TVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGT 85

  Fly    71 SNES------YEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRF-GQATRLSAS 128
            ...|      :|:..:|.|:         :..:.|:||:......::.:||.:|| |:..||..|
  Rat    86 GAASGLAVAGFEWNALFVVL---------LLGWLFVPVYLTAGVITMPQYLRKRFGGRRIRLYLS 141

  Fly   129 LAFTVQMVLY----MGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQS 189
            :   :.:.||    :.:.:::.|:.::...|.:...:::.:..:...|:..|||.|::.||..|:
  Rat   142 V---LSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQT 203

  Fly   190 FLMFAAIYAVIAVSAIKAGGFAAIWDVAVERGRVNFIEFSLDPTVRH------------------ 236
            |::.|..:.:...:..:.||::.::|..:  |.|..:..|.||.|.:
  Rat   204 FVILAGAFILTGYAFHEVGGYSGLFDKYL--GAVTSLTVSKDPAVGNISSTCYQPRPDSYHLLRD 266

  Fly   237 ------TWWSLIIGGMVTYLSLYGVNQTQVQRLLSVRNLK--SAQSALWWNLPILGMLSFSTIFS 293
                  .|.:|::|..:.....:..:|..|||.|:.:||.  .|...|...|.::.|  |..:..
  Rat   267 PVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPM--FLMVMP 329

  Fly   294 GLSIFYYYRD---------CDPLLKGRIDKRDQIMPLFALETMGQYPGLCGLFVSGIFSASLSTI 349
            |:.....|.|         |..:....:...:...|...::.|..  ||.||.::.:.:|.:|::
  Rat   330 GMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPN--GLRGLMLAVMLAALMSSL 392

  Fly   350 SSAVTSLSAV-TLEDYLKPLYKAIFKRTLIDSKSTMPTKIVACIFGLLCIGLAFVAGSMGGVLQA 413
            :|...|.|.: |::.|.:...:|..:..|:..:..     |..|..:....|..|..:.||.|..
  Rat   393 ASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLW-----VVFIVAVSVAWLPVVQAAQGGQLFD 452

  Fly   414 SL-TIFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVSFWMGFGGPKPKPVTLEFSTAGCE 477
            .: ::...:..|:.|:|.|.:...|.|::|...|.:..|:    ||.....|:   ..|.|..|.
  Rat   453 YIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLIGGLL----MGLARLIPE---FFFGTGSCV 510

  Fly   478 NATAVMARAIELSSKSSGVVIEPDYFWLYRISYLWLSVIGFLIAVVVGYFSSIVLAHCGKAENAE 542
            ..:|.                 |..|  .|:.||:.::|.|..:    .|.::.::.|    .|.
  Rat   511 RPSAC-----------------PAIF--CRVHYLYFAIILFFCS----GFLTLAISLC----TAP 548

  Fly   543 IYLDKSRKQLDYDLFAPMLSRRWRRHKEEQDQTAQDE 579
            |    .:|.|...:|:      .|..|||::....:|
  Rat   549 I----PQKHLHRLVFS------LRHSKEEREDLDAEE 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	125/572 (22%)
Slc5a2	NP_072112.2	SLC5-6-like_sbd	22..670	CDD:382020	136/622 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810