DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10444 and Slc5a4b

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_075708.2	Gene:	Slc5a4b / 64454	MGIID:	1890478	Length:	660	Species:	Mus musculus

Alignment Length:	569	Identity:	119/569 - (20%)
Similarity:	235/569 - (41%)	Gaps:	92/569 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPVGTFDAWDAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSAI 65
            :||...:|.|.:|::...::...:|: :......:.|...:.:|...|..:|:..||.||.:.:.
Mouse    19 VPVRIQNAADISVIVIYFIVVLAVGL-WSMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSN 82

  Fly    66 SLMGVSNESYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLS---A 127
            ..:|::......|.....:....:|...:..:.|||::.:....::.|||.:||| ..||.   :
Mouse    83 HFVGLAGTGAASGIAIAAVEWNALLMVLVLGWVFLPIYIKAGVLTMPEYLRKRFG-GKRLQIYLS 146

  Fly   128 SLAFTVQMVLYMGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQSFLM 192
            .|:..:.:.|.....:::.|:.::...|::..:|:.::..:..||:..|||.:|:.||..|:|:|
Mouse   147 VLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLAITAFYTVAGGLASVIYTDSVQTFIM 211

  Fly   193 FAAIYAVIAVSAIKAGGFAAIWD-------VAVERGRVNFIE--FSLDPTVRHT----------W 238
            ......::..:..:.||:.:..:       ..||...:....  ::..|...|.          |
Mouse   212 LLGSLILMGFAFAEVGGYESFTEKYMNAIPSVVEGDNLTISPKCYTPQPDSFHVFRDPVTGDIPW 276

  Fly   239 WSLIIGGMVTYLSLYGVNQTQVQRLLSVRNLKSAQSA--LWWNLPILGMLSFSTIFSGLSIFYYY 301
            ..||.|..:..:..:..:|..|||.|..:|:...::|  |...|.:|.|  |..:..|:.....|
Mouse   277 PGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPM--FLMVMPGMISRILY 339

  Fly   302 RD---------CDPLLKGRIDKRDQIMPLFALETMGQYPGLCGLFVSGIFSASLSTISSAVTSLS 357
            .|         |:......:...:...|...||.|..  ||.||.:|.:.::.:|:::|...|.|
Mouse   340 TDKVACVVPSECEKQCGTAVGCTNYAYPTLVLELMPD--GLRGLMLSVMLASLMSSLTSIFNSAS 402

  Fly   358 AV-TLEDYLKPLYKAIFKRTLIDSKSTMPTKIVACIFGLLCIGLA-----FVAGSMGGVLQASL- 415
            .: |::.|.|...||..:..:|..:          |||::.|.::     .|..|..|.|...:
Mouse   403 TLFTIDLYTKIRKKASERELMIAGR----------IFGMVLIAVSILWVPLVQVSQNGQLFHYIG 457

  Fly   416 TIFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVSFWMGFGGPKPKPVTLEF--STAGC-- 476
            ::...:|.||.|:|.|.:...|.|::|...|.:|.|:|....         :..||  .|..|
Mouse   458 SVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIR---------LIAEFVYGTGSCVA 513

  Fly   477 -ENATAVMARAIELSSKSSGVVIEPDYFWLYRISYLWLSVIGFLIAVVV 524
             .|...::.                      .:.|::.::|.|.::::|
Mouse   514 PSNCPKIIC----------------------GVHYMYFAIILFFVSIIV 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	116/561 (21%)
Slc5a4b	NP_075708.2	SLC5-6-like_sbd	27..660	CDD:294310	116/561 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810