DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10444 and slc5a6a

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001020700.2	Gene:	slc5a6a / 563356	ZFINID:	ZDB-GENE-041001-177	Length:	625	Species:	Danio rerio

Alignment Length:	536	Identity:	224/536 - (41%)
Similarity:	327/536 - (61%)	Gaps:	24/536 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FDAWDAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSAISLMGV 70
            |...|..:.:.:||.||.||:||.::||:|:||||:|:||:||...|||.||:|:|.||::::|.
Zfish     9 FSTVDYVIFVVLLVASAGIGLYYAFSGGRQRTTQEFLLADRSMRCLPVSLSLLATFQSAVAILGA 73

  Fly    71 SNESYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLSASLAFTVQM 135
            .:|.|.:||.:..:..:|.|...|.|:.|:|||||:|.:|.|||||.||.::.|:..::.|..||
Zfish    74 PSEIYTYGTQYWFLGCSYFLGLLIPAHIFIPVFYRLRLSSAYEYLELRFSKSVRICGTVTFIFQM 138

  Fly   136 VLYMGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQSFLMFAAIYAVI 200
            |:|||:.||||||||.||||.....|::.:|||||.|:.|||||||:.|||||:.:|||...|||
Zfish   139 VIYMGVVLYAPALALNAVTGFDLWGAVLAMGLVCTLYTALGGLKAVIWTDVFQTIVMFAGQLAVI 203

  Fly   201 AVSAIKAGGFAAIWDVAVERGRVNFIEFSLDPTVRHTWWSLIIGGMVTYLSLYGVNQTQVQRLLS 265
            .|...:|||.|.:|..|....|:..::.:.||..|||:|:|.:||:...|:||||||.||||.||
Zfish   204 VVGTHQAGGIAEVWRKAQNGSRIAGLDLNPDPLERHTFWTLGVGGVFLMLALYGVNQAQVQRYLS 268

  Fly   266 VRNLKSAQSALWWNLPILGMLSFSTIFSGLSIFYYYRDCDPLLKGRIDKRDQIMPLFALETMGQY 330
            .|..|.|..:.:...|...::.......||.::..|.:..||.:|.:...||::....::.:...
Zfish   269 SRTEKEAIMSCYAVFPCQQVVLTLGCLMGLVMYARYGEESPLDQGYVTTNDQMVLYLVMDVLRDL 333

  Fly   331 PGLCGLFVSGIFSASLSTISSAVTSLSAVTLEDYLKPLYKAIFKRTLIDSKSTMPTKIVACIFGL 395
            |||.||||:.:||.:|||||||..||:.||:||.:||...|     :.::::|:.:|::|..:||
Zfish   334 PGLPGLFVACLFSGALSTISSAFNSLATVTMEDLIKPHVPA-----MTEARATLLSKMLALAYGL 393

  Fly   396 LCIGLAFVAGSMGGVLQASLTIFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVSFWMGFG 460
            :|:.:|::|..||.||||:|:|||:||||||.:|.||:....:|..|.|:|....|:::||:|.|
Zfish   394 VCLAMAYIASLMGSVLQAALSIFGMVGGPLLGLFCLGMFFPWANSTGALVGLASGLVMAFWIGIG 458

  Fly   461 GPKPKPVTLEFSTAGCENA----------TAVMARAIELSSKSSGVVIEPDYFWLYRISYLWLSV 515
            ....:   :..|.....||          ||||........:.|||..      ||.:||:|.|.
Zfish   459 SFVSR---MSLSALPVINATIIPDVGNMTTAVMTTLTTTKPRPSGVQA------LYSLSYMWYSA 514

  Fly   516 IGFLIAVVVGYFSSIV 531
            ......||||...|.:
Zfish   515 HNSATVVVVGLVVSFL 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	223/531 (42%)
slc5a6a	NP_001020700.2	SLC5-6-like_sbd	9..532	CDD:294310	224/536 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596893
Domainoid	1	1.000	358	1.000	Domainoid score	I922
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1798
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D327628at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm6386
orthoMCL	1	0.900	-	-		OOG6_101204
Panther	1	1.100	-	-	LDO	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760