DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10444 and Slc5a8

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001178916.1	Gene:	Slc5a8 / 500820	RGDID:	1564146	Length:	611	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	239/575 - (41%)
Similarity:	355/575 - (61%)	Gaps:	33/575 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VGTFDAWDAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSAISL 67
            :|:|..||..|...:|:|||.|||||.:.||.|:|::::||..:||:..||:.||.||||||:::
  Rat     7 IGSFVVWDYVVFAGMLLISAAIGIYYAFAGGGQQTSKDFLMGGRSMSAVPVALSLTASFMSAVTV 71

  Fly    68 MGVSNESYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLSASLAFT 132
            :|...|.|.||.||.:..:.|.....|:|..|||||||:..||.|||||.||.:..||..::.|.
  Rat    72 LGTPAEVYRFGAIFSIFGVTYFFVVVISAEVFLPVFYRLGITSTYEYLELRFNRFIRLCGTVLFI 136

  Fly   133 VQMVLYMGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQSFLMFAAIY 197
            ||.:||.||.:|||||||..|||.....|:|..|:|||||.||||||||:.|||||..:|.|...
  Rat   137 VQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFA 201

  Fly   198 AVIAVSAIKAGGFAAIWDVAVERGRVNFIEFSLDPTVRHTWWSLIIGGMVTYLSLYGVNQTQVQR 262
            :||..::|..||...|...|...||:||..|:.:|..|||:|::|:||..|:.::|||||:||||
  Rat   202 SVIIQASITQGGINTILSDASNGGRLNFWNFNPNPLQRHTFWTIIVGGTFTWTTIYGVNQSQVQR 266

  Fly   263 LLSVRNLKSAQSALWWNLPILGMLSFSTIFSGLSIFYYYRDCDPLLKGRIDKRDQIMPLFALETM 327
            .:|.::...|:.:|:.||..|.::...::|.||:::..|.||||....::.:.||:||...|:.:
  Rat   267 YISCKSRLHAKLSLYVNLVGLWVILICSVFCGLALYSRYHDCDPWTSKKVSEVDQLMPYLVLDIL 331

  Fly   328 GQYPGLCGLFVSGIFSASLSTISSAVTSLSAVTLEDYLKPLYKAIFKRTLIDSKSTMPTKIVACI 392
            ..|||:.||||:..:|.:|||:||::.:|:|||:||.:||.:|::.:::|     :..::.::.:
  Rat   332 KNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFKSLSEKSL-----SWISQGMSVL 391

  Fly   393 FGLLCIGLAFVAGSMGGVLQASLTIFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVSFWM 457
            :|.||||:|.||..||.:|||:|:|||:||||||.:|:||:....:|..|...|.|....||.|:
  Rat   392 YGALCIGMAAVASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSVGAFAGLLAGFAVSLWV 456

  Fly   458 GFGG----PKPK---PVTLEFSTAGC---ENATAVMA--------RAIELSSKSSGVVIEPDYFW 504
            |.|.    |.|:   |::||  |.||   .|.|..|:        .|.::.......:::.   |
  Rat   457 GIGAQLYPPLPERTLPLSLE--THGCNSTHNGTDWMSTTEMPFSTSAFQIHDVERSALMDN---W 516

  Fly   505 LYRISYLWLSVIGFLIAVVVGYFSSIVLAHCGKAENAE--IYLDKSRKQLDYDLF 557
             |.:|||:.|.||.|..::||..  |.||..|:.:|.:  ..|.|.....::|:|
  Rat   517 -YSLSYLYFSTIGTLTTLLVGIL--ISLATGGRKQNLDPRFLLTKQDFLSNFDVF 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	228/539 (42%)
Slc5a8	NP_001178916.1	SLC5sbd_SMCT1	7..549	CDD:271402	234/554 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	371	1.000	Domainoid score	I866
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1652
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9146
orthoMCL	1	0.900	-	-		OOG6_101204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770