DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10444 and slc5a11

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001007301.1	Gene:	slc5a11 / 492334	ZFINID:	ZDB-GENE-041114-9	Length:	668	Species:	Danio rerio

Alignment Length:	567	Identity:	127/567 - (22%)
Similarity:	232/567 - (40%)	Gaps:	101/567 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TFDAWDAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSAISLMG 69
            |....|..||:...::...:|::..:. .|:.|...|.:|.::||.:||..||.||.:.:...:|
Zfish    23 TLATTDIVVLVIYFLLVLAVGLWSMWK-TKRSTVDGYFLAGKNMTWWPVGASLFASNVGSGHFIG 86

  Fly    70 VSNESYEFGTIFCVINIAY----VLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLSASLA 130
            ::......|    :..:||    :|...:..:.|||::...|.|::.|||::||| ..|:...|.
Zfish    87 LAGSGAAAG----IGAVAYEWNGMLMVLVMGWLFLPIYIASRVTTMPEYLKKRFG-GKRIQLFLC 146

  Fly   131 FTVQMVLYM--------GIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVF 187
                 |||:        .:.:||.|:.::.....:..:|:|::..:...|:..|||.||:.||..
Zfish   147 -----VLYLFIYIFTKISVDMYAGAVFIQQALQWNIYLAVVLLLGITALYTIAGGLAAVIYTDAV 206

  Fly   188 QSFLMFAAIYAVIAVSAIKAGGFAAIWD---VAVERGRV-----------NFIEFSLDPTVRHTW 238
            |:.:|......::..|..:.|||.|:.|   .|:...||           .|..|....|....|
Zfish   207 QTIIMVIGALILMGFSFAEVGGFEAVLDKYPQAIPSIRVPNTTCGIPRDDAFHIFRHPVTSDLPW 271

  Fly   239 WSLIIGGMVTYLSLYGVNQTQVQRLLSVRNLKSAQSALWWNLPILGMLSFSTIFSGLSIFYYYRD 303
            ..:|:|..:..:..:..:|..|||.|:.:|:..|:........|..:..|..:..|:.....|.|
Zfish   272 PGVILGMSIPSMWYWCSDQVIVQRSLAAKNILHAKGGSLLAAYIKVLPFFMMVIPGMISRILYPD 336

  Fly   304 ---------CDPLLKGRIDKRDQIMPLFALETMGQYPGLCGLFVSGIFSASLSTISSAVTSLSAV 359
                     |..:....:...|.......:|.:.  .||.||.::.:.:|.:|:::|...|.|.:
Zfish   337 EVGCGDPEVCKEVCGNSVGCSDIAYAKLVMELLP--AGLRGLMMAVMLAALMSSLTSIFNSSSTI 399

  Fly   360 TLEDYLKPLYKAIFKRTLIDSKSTMPTKIVACIFGLLCI-----GLAFVAGSMGG---VLQASLT 416
            ...|         ..|.:..:.|.....||..:|.|:.:     .:..|..|.||   :...|::
Zfish   400 FTMD---------LWRNIRHTASEWELMIVGRVFVLVLVVVSVLWIPLVQASQGGQLFIYIQSIS 455

  Fly   417 IFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVS---FWMGFGGPKPKPVTLEFSTAGC-E 477
            ::  :..|:..||..|....|:|::|...|.:|.:.|.   ..:.|..|.|:          | |
Zfish   456 MY--LQPPITVIFVAGCFWKRTNEKGAFWGLMVGMAVGCTRMILDFIYPTPQ----------CYE 508

  Fly   478 NATAVMARAIELSSKSSGVVIEPDYFWLYRISYLWLSVIGFLIAVVV 524
            :.|                  .||.  :..:.:|:.|:|..::.:||
Zfish   509 SDT------------------RPDI--IKYVHFLYFSIILTILTLVV 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	126/563 (22%)
slc5a11	NP_001007301.1	SLC5sbd_SGLT6	28..668	CDD:271381	126/562 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810