DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10444 and CG6723

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	601	Identity:	195/601 - (32%)
Similarity:	315/601 - (52%)	Gaps:	61/601 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AW-DAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSAISLMGVS 71
            || |....:::.::...||||:.:. .|..:..:|::..:.|...|::|||:|||:|.|:|:|:.
  Fly    15 AWPDYVAFVSMFLLCIGIGIYFGFM-NKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITLLGLP 78

  Fly    72 NESYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLSASLAFTVQMV 136
            .|.|.:|..:..::...:....:...|:||||:.:..||.|||||.||.:..||..|:.|.:..|
  Fly    79 TEVYSYGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRFDRRLRLYGSVMFAIMNV 143

  Fly   137 LYMGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQSFLMFAAIYAVIA 201
            .|:.|.:|.||||...||||.......::.::|.||::|||||||:.|||.|:..|..|:..|..
  Fly   144 AYLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGALCLVAI 208

  Fly   202 VSAIKAGGFAAIWDVAVERGRVNFIEFSLDPTVRHTWWSLIIGGMVTYLSLYGVNQTQVQRLLSV 266
            ......||...:.:.|....|:...:.|:|||||||:|.|..||:|.:.....|:|..:||.||:
  Fly   209 KGTRDIGGAGVVLERAWSSDRLEAPDLSIDPTVRHTFWCLFFGGIVYWTQTNAVSQNMIQRYLSL 273

  Fly   267 RNLKSAQSALWWNLPILGMLSFSTI--FSGLSIFYYYRDCDPLLKGRIDKRDQIMPLFALETMGQ 329
            .:|..|:.||.  :..:|:|....:  ::||.|:..|::||||.......|||::|||.::|:|:
  Fly   274 PSLGDARKALC--IFCVGVLILMALCGYNGLLIYATYQNCDPLTTKLAKARDQLLPLFVMKTLGE 336

  Fly   330 YPGLCGLFVSGIFSASLSTISSAVTSLSAVTLEDYLKPLYKAIFKRTLIDSKSTMPTKIVACIFG 394
            .||:.|||::|:|||:||::|:.:.|:|||.|||::||    ..|:.|..|......::|....|
  Fly   337 LPGMTGLFIAGVFSAALSSLSTCLNSMSAVVLEDFVKP----YVKKPLSSSAINWIMRLVVVGVG 397

  Fly   395 LLCIGLAFVAGSMGGVLQASLTIFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVSFWMGF 459
            :||:.|.:|...||.|||.::::..:..|||..|||:|:.....|....|:|.::.:|...|:..
  Fly   398 VLCVCLVYVVEHMGTVLQLTMSLEAITNGPLFGIFTIGLFLPWINGNSALVGGVMGVIAMSWVSL 462

  Fly   460 GGP----------KPKPVTLEFSTAGCE---NATAVMARAIELSSKSSGVVIEPDYFWLYRISYL 511
            ...          |.||:.:|    .|:   |.|..:|....|.:.:.      |.|.||||||:
  Fly   463 NAQWAIASGAITYKTKPLNVE----QCDYSFNVTTSLANTTHLGASAE------DIFPLYRISYM 517

  Fly   512 WLSVIGFLIAVVVGYFSS-------------IVLAHCGK---AENAEIYLDKSRKQLDYDLFAPM 560
            |.:..|..|.:.|....:             ::|..|.:   |..:|.::|..|..:      |:
  Fly   518 WYTTFGASITIFVALLGTFVFGKNNPNKVDPVLLTPCIRKFFAFGSEKHMDAFRPDI------PL 576

  Fly   561 LSRRWRRHKEEQDQTA 576
                  :||...|:.|
  Fly   577 ------QHKLRNDEVA 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	183/550 (33%)
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	182/536 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448274
Domainoid	1	1.000	233	1.000	Domainoid score	I1353
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I1946
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	10	9.900