DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10444 and slc5a12

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_956662.1	Gene:	slc5a12 / 393339	ZFINID:	ZDB-GENE-040426-1343	Length:	623	Species:	Danio rerio

Alignment Length:	607	Identity:	214/607 - (35%)
Similarity:	336/607 - (55%)	Gaps:	48/607 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VGTFDAWDAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSAISL 67
            ||.|.|.|..|...:.|:|:.||:::......:..::|:|:..:.|:..||:.||.||||||:::
Zfish     4 VGRFQAGDYVVFACLFVVSSGIGVFFAIKERNKAPSKEFLVGGRQMSCGPVALSLTASFMSAVTV 68

  Fly    68 MGVSNESYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLSASLAFT 132
            :|...:.|.||..:.:..:||.......|..|||||||...||.|||||.||.:..|::|:|.:.
Zfish    69 IGAPADVYRFGASYVIFGVAYTFVVFFTAELFLPVFYRSGITSTYEYLELRFCKLVRVAATLIYI 133

  Fly   133 VQMVLYMGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQSFLMFAAIY 197
            :|.:||.|:.:|||||||..|||.....:|...|:|||||.||||||||:.||.||..:|.....
Zfish   134 IQTILYTGVVVYAPALALNQVTGFDLWGSIFATGIVCTFYCTLGGLKAVVWTDAFQMVVMVVGFL 198

  Fly   198 AVIAVSAIKAGGFAAIWDVAVERGRVNFIEFSLDPTVRHTWWSLIIGGMVTYLSLYGVNQTQVQR 262
            .|:...:.:|||...:|..:...||:...:|.:.|..|||:|:|.:||..|:|.:|||||:.:||
Zfish   199 TVLIQGSSRAGGIENVWSTSRTGGRLQVFDFDVSPLRRHTFWTLSVGGTFTWLGIYGVNQSTIQR 263

  Fly   263 LLSVRNLKSAQSALWWNLPILGMLSFSTIFSGLSIFYYYRDCDPLLKGRIDKRDQIMPLFALETM 327
            .:|.:....|:.||:.||..|.::.|..:.|||.::.||..|||...|.|...||:||.|.:|.:
Zfish   264 CISCKTEGHARWALYLNLLGLWIILFCAVVSGLIMYSYYSHCDPWSSGLISAPDQLMPYFVMEIL 328

  Fly   328 GQYPGLCGLFVSGIFSASLSTISSAVTSLSAVTLEDYLKPLYKAIFKRTLIDSKSTMPTKIVACI 392
            |.:|||.||||:..||.:|||:::::.:|:.|..||::...:..:..|.     ::..:|.:...
Zfish   329 GAFPGLPGLFVACAFSGTLSTVAASINALATVMYEDFVSQCFPDLSNRA-----ASWISKALCVA 388

  Fly   393 FGLLCIGLAFVAGSMGGVLQASLTIFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVSFWM 457
            ||:.|..:|..|..|||::||:|:|.|:.|||:|.:|:||:....:|.:|.:.|.:|.:.:|||:
Zfish   389 FGVACTTMAVAASYMGGIVQAALSIHGMCGGPVLGLFSLGILFPFTNLKGAVGGLIVGISLSFWV 453

  Fly   458 GFGG---PKPKPVT--LEFSTAGCENATAVMARAIELSSKSSGVVIEPDYFWL----YRISYLWL 513
            |.|.   |.|...|  ||.:||||.    :.|.|.|.:| ::...:..|..||    |.:|||:.
Zfish   454 GVGAFIYPAPSNNTHALELNTAGCN----ITAAAFEPTS-ATVTQLTSDRNWLADSWYSMSYLYY 513

  Fly   514 SVIGFLIAVVVGYFSSI--------------------VLAHCGKAENAEIYLDKSRKQL-DYDLF 557
            |.:||:..|..|...::                    |:..|.: :..|..|.:.::.: |:
Zfish   514 SAVGFIGTVAAGLLITLLTGPMDPKLLKPGMTRSVKEVMCFCTE-KFTEADLGEGKEDVGDF--- 574

  Fly   558 APMLSRRWRRHKEEQDQTAQDE 579
                .:.|.:|.::......||
Zfish   575 ----GKAWEKHPDQGCTLRMDE 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	201/550 (37%)
slc5a12	NP_956662.1	SLC5sbd_SMCT2	4..533	CDD:212089	205/538 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	358	1.000	Domainoid score	I922
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15107
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1798
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm6386
orthoMCL	1	0.900	-	-		OOG6_101204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.870