DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10444 and CG5687

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001286910.1	Gene:	CG5687 / 38255	FlyBaseID:	FBgn0035293	Length:	683	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	207/587 - (35%)
Similarity:	328/587 - (55%)	Gaps:	63/587 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TFDAWDAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSAISLMG 69
            ||..:|..:|:.:||||..|||:|.:......::.|:|:..: |:.|||:.||..||::||.|:|
  Fly    95 TFSGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGSE-MSIFPVTLSLTTSFITAIELLG 158

  Fly    70 VSNESYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLSASLAFTVQ 134
            ..:|.|..||.|.:|.|..|:..|:|...|.|::::|..||.||||..|||:..|:..::.:.:|
  Fly   159 NPSEMYFQGTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRFGKEIRILGAVLYVIQ 223

  Fly   135 MVLYMGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQSFLMFAAIYAV 199
            |..|..:|:.|||:||...||:...:|:|:|.:||.|||:.||:|||:|.|.||:.::..::..:
  Fly   224 MCFYTAVAVLAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVVIADSFQAAVLAVSLVLI 288

  Fly   200 IAVSAIKAGGFAAIWDVAVERGRVNFIEFSLDPTVRHTWWSLIIGGMVTYLSLYGVNQTQVQRLL 264
            :.:....:|....::..|.:..|:.|.....|||.|||.||::|||...:.||:..||..||:.:
  Fly   289 VGLGCFYSGNPIQVFQTASDHNRLEFFNMDPDPTTRHTVWSVVIGGFFYWTSLFCTNQASVQKCM 353

  Fly   265 SVRNLKSAQSALWW---NLPILGMLSFSTIFSGLSIFYYYRDCDPLLKGRIDKRDQIMPLFALET 326
            |:::|:.|:.||.:   .|.::.:|:|   ::||.:|.:|.|||||..|||...||::|.:.:.|
  Fly   354 SLKSLRLAKIALGFAIIGLIVVFLLNF---YTGLMVFTHYADCDPLTAGRISATDQLLPYYVINT 415

  Fly   327 MGQYPGLCGLFVSGIFSASLSTISSAVTSLSAVTLEDYL--------KPLYKAIFKRTLIDSKST 383
            ......:.|:||:|||:|||.|::||:.||||||.||.|        .|            .|..
  Fly   416 YEHISSVAGIFVAGIFAASLGTVASALNSLSAVTCEDLLVNGMNIKISP------------EKGA 468

  Fly   384 MPTKIVACIFGLLCIGLAFVAGSMGGVLQASLTIFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFL 448
            ...|.::..||:...||.|:...:||||||:||:.|::||..|.:|.||:...::|.:|...|.|
  Fly   469 TYAKWMSLGFGIASFGLVFIVEHLGGVLQATLTLNGLIGGVTLGLFVLGIACKQANTKGAFYGGL 533

  Fly   449 VSLIVSFWMGFGGP--KPKPVTLEFSTAGCE---NAT----AVMARAIELSSKSSGVVIEPDYF- 503
            :||.:..::|....  ..:...|..|...|:   |.|    :::...:|        |||...|
  Fly   534 LSLALVIFVGVVAQIVSVEQPALPTSIDKCDCHVNMTNIIGSLLTEPLE--------VIEEGGFT 590

  Fly   504 -W-LYRISYLWLSVIGFLIAVVVGYFSSI---------VLAHCGK-----AENAEIYLDKSRKQL 552
             | ::|:||:|.|:||.|:.|.:|:|.|:         ||...||     |.:.||:  ||..|:
  Fly   591 SWPIFRLSYMWYSMIGCLLTVFLGWFISLIIDFIQRRNVLKITGKDIDNPAVSEEIF--KSDSQV 653

  Fly   553 DY 554
            .|
  Fly   654 QY 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	194/553 (35%)
CG5687	NP_001286910.1	SLC5sbd_NIS-SMVT	99..620	CDD:271383	194/544 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	233	1.000	Domainoid score	I1353
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I1946
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	9	8.970