DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10444 and Slc5a12

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001102058.1	Gene:	Slc5a12 / 362188	RGDID:	1311652	Length:	619	Species:	Rattus norvegicus

Alignment Length:	596	Identity:	218/596 - (36%)
Similarity:	337/596 - (56%)	Gaps:	41/596 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPVGTFDAWDAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSAI 65
            |.|.:|:|||..|...:.|||:.||:::.....|:.|::|:|:..:.|:..||:.||.||||||:
  Rat     1 MAVKSFEAWDYVVFAALFVISSGIGVFFAIKERKKTTSREFLVGGRQMSFAPVALSLTASFMSAV 65

  Fly    66 SLMGVSNESYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLSASLA 130
            :::|...|.|.||..|.:..|:|.......:..|||||||...||.||||:.||.:..|.:|::.
  Rat    66 TVLGTPAEVYRFGASFLIFLISYAFVVFFTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATII 130

  Fly   131 FTVQMVLYMGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQSFLMFAA 195
            :.:|.:||.|:.:|||||||..|||.:...::...|:|||||.:|||||||:.||.||..:|...
  Rat   131 YILQTILYTGVVVYAPALALNQVTGFNLWASVFATGIVCTFYCSLGGLKAVVWTDAFQMVVMIVG 195

  Fly   196 IYAVIAVSAIKAGGFAAIWDVAVERGRVNFIEFSLDPTVRHTWWSLIIGGMVTYLSLYGVNQTQV 260
            ...|:...:...|||..:.:.|....|::.::|.:||..|||:|::.:||..|:|.:|||||:.:
  Rat   196 FLTVLIQGSNHVGGFDNVLEQARNGSRLDIVDFDVDPLRRHTFWTIAVGGTFTWLGIYGVNQSTI 260

  Fly   261 QRLLSVRNLKSAQSALWWNLPILGMLSFSTIFSGLSIFYYYRDCDPLLKGRIDKRDQIMPLFALE 325
            ||.:|.:..|.|:.||::||..|.::....:|.||.::.||:||||...|.|...||:||.|.:|
  Rat   261 QRCISCKTEKHAKLALYFNLLGLWIIVVCAVFCGLIMYAYYKDCDPWTSGAILAPDQLMPYFVME 325

  Fly   326 TMGQYPGLCGLFVSGIFSASLSTISSAVTSLSAVTLEDYLKPLYKAIFKRTLIDSKSTMPTKIVA 390
            .....|||.||||:..||.:|||:::::.:|:.||.||::|..:.     .|.|:.||..:|.:.
  Rat   326 IFATMPGLPGLFVACAFSGTLSTVAASINALATVTFEDFVKSCFP-----HLSDTLSTWISKGLC 385

  Fly   391 CIFGLLCIGLAFVAGSMGGVLQASLTIFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVSF 455
            .:||::|..:|.:|..||.|:||:|:|.|:.|||:|.:||||:.....|.:|.|.|.|..:.:||
  Rat   386 LLFGIICTSMAVLASLMGSVVQAALSIHGMCGGPMLGLFTLGLVFPFVNWKGALGGLLTGITLSF 450

  Fly   456 WMGFG-----GPKPKPVTLEFSTAGCENATAVMARAIELSSKSSGVVIEPDYFWLYRISYLWLSV 515
            |:|.|     .|..|.:.|..||..|.........|.:|||:.  |:.:.   | |.:|||:.|.
  Rat   451 WVGIGAFVYPAPDSKTLPLPLSTEFCVQQNKTTTEAYQLSSRP--VLADT---W-YSLSYLYFSA 509

  Fly   516 IGFLIAVVVGYFSSIVLAHCGKAENAEIYLDKSRKQLDYDLFAPML------SRRWR-------R 567
            :|.|..:..|...|.:...            :..|.:|..|..|:.      |::::       |
  Rat   510 VGCLGCIAAGIIISFLTGR------------QRGKDVDPLLIRPVCNLFCFWSKKYKTLCWCGVR 562

  Fly   568 HKEEQDQTAQD 578
            |.:|.:|...|
  Rat   563 HDQETEQDYLD 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	204/526 (39%)
Slc5a12	NP_001102058.1	SLC5sbd_SMCT2	3..527	CDD:212089	207/534 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	371	1.000	Domainoid score	I866
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15107
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1652
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9146
orthoMCL	1	0.900	-	-		OOG6_101204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.770