DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10444 and Slc5a6

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001171092.1	Gene:	Slc5a6 / 330064	MGIID:	2660847	Length:	634	Species:	Mus musculus

Alignment Length:	590	Identity:	228/590 - (38%)
Similarity:	337/590 - (57%)	Gaps:	43/590 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VGTFDAWDAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSAISL 67
            :.||...|..|...:||:|.:||:|:...|....|..|.||||:.|...||:.||:|:|.||:::
Mouse    20 ISTFSVVDYVVFGLLLVLSLVIGLYHACRGWGHHTVGELLMADRKMGCLPVALSLLATFQSAVAI 84

  Fly    68 MGVSNESYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLSASLAFT 132
            :|...|.:.|||.:..:..:|.|...|.|:.|:|||||:..||.|||||.||.:|.|:..::.|.
Mouse    85 LGAPAEIFRFGTQYWFLGCSYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRFNKAVRICGTVTFI 149

  Fly   133 VQMVLYMGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQSFLMFAAIY 197
            .|||:|||:|||||:|||.||||....::::.:|:||..|:.|||||||:.|||||:.:||....
Mouse   150 FQMVIYMGVALYAPSLALNAVTGFDLWLSVLALGIVCNIYTALGGLKAVIWTDVFQTLVMFLGQL 214

  Fly   198 AVIAVSAIKAGGFAAIWDVAVERGRVNFIEFSLDPTVRHTWWSLIIGGMVTYLSLYGVNQTQVQR 262
            .||.|.|.:.||...:|:|..:.|.::.|....||.||||:|:|..||:...||||||||.||||
Mouse   215 VVIIVGAARVGGLGHVWNVTSQHGLISGINLDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQR 279

  Fly   263 LLSVRNLKSAQSALWWNLPILGMLSFSTIFSGLSIFYYYR--DCDPLLKGRIDKRDQIMPLFALE 325
            .||..:.::|..:.:...|...:....:...||.:|.||.  ...|.||....  ||::..|.::
Mouse   280 YLSSHSERAAVLSCYAVFPCQQVALCMSCLIGLVMFAYYNMYSMSPELKQAAP--DQLVLYFVMD 342

  Fly   326 TMGQYPGLCGLFVSGIFSASLSTISSAVTSLSAVTLEDYLKPLYKAIFKRTLIDSKSTMPTKIVA 390
            .:...|||.||||:.:||.||||||||..||:.||:||.::|.:.     .|.::::.|.::.:|
Mouse   343 LLKDMPGLPGLFVACLFSGSLSTISSAFNSLATVTMEDLIQPWFP-----QLTETRAIMLSRGLA 402

  Fly   391 CIFGLLCIGLAFVAGSMGGVLQASLTIFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVSF 455
            ..:||:|:|:|:::..:|.||||:|:|||:||||||.:|.||:....:|..|.::|.|..|.::|
Mouse   403 FAYGLVCLGMAYISSHLGSVLQAALSIFGMVGGPLLGLFCLGLFFPCANPLGAIVGLLTGLTMAF 467

  Fly   456 WMGFG----------GPKPKPVTLEFSTAGCENA--TAVMARAIELSSKSSGVVIEPDYFWLYRI 508
            |:|.|          .|.|...:..|..|....|  |.||...:   ||.:|:    .:|  |.:
Mouse   468 WIGIGSIVSRMSSAVAPPPLNGSSSFLPANVTVAAVTTVMPSTL---SKPTGL----QHF--YSL 523

  Fly   509 SYLWLSVIGFLIAVVVGYFSSIVLAHC-GKAEN-AEIY--LDKSRKQLDYDLFAPMLSRR---WR 566
            ||||.|.......:|||...|::.... |::.| ..||  |.|....|      |:..::   ||
Mouse   524 SYLWYSAHNSTTVIVVGLIVSLLTGGMRGRSLNPGTIYPVLPKLLALL------PLSCQKRLCWR 582

  Fly   567 RHKEE 571
            .|.::
Mouse   583 SHSQD 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	215/535 (40%)
Slc5a6	NP_001171092.1	SLC5-6-like_sbd	23..548	CDD:320982	216/540 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850849
Domainoid	1	1.000	366	1.000	Domainoid score	I922
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1711
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm8902
orthoMCL	1	0.900	-	-		OOG6_101204
Panther	1	1.100	-	-	LDO	PTHR42985
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6277
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790