DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10444 and Slc5a4

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001099853.1	Gene:	Slc5a4 / 294341	RGDID:	1306923	Length:	671	Species:	Rattus norvegicus

Alignment Length:	638	Identity:	142/638 - (22%)
Similarity:	269/638 - (42%)	Gaps:	125/638 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSAISLMGVSNES 74
            |.:|::...|:...:|: :......:.|...:.:|.:|||.:|:..||.||.:.:...:|::...
  Rat    39 DISVIVIYFVVVMAVGV-WAMVKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTG 102

  Fly    75 YEFG---TIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLS---ASLAFTV 133
            ...|   |.|...:.|.:|   :..:||:|::.:....::.|||.:||| ..||.   :.|:..:
  Rat   103 AATGIAVTAFESHSFALLL---VLGWFFVPIYIKAGVMTMPEYLRKRFG-GKRLQIYLSVLSLFI 163

  Fly   134 QMVLYMGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQSFLMFAAIYA 198
            .::|.:...:::.|:.::...|:...:||.::..:...::..|||.:|:.||..|:.:|....:.
  Rat   164 CVILTISADIFSGAIFIKLALGLDLYLAIFILLAITAVFTITGGLASVIYTDTLQAIIMLVGSFI 228

  Fly   199 VIAVSAIKAGGFAAIWD-------VAVERGRVNFIE--FSLDPTVRHTWWSLIIG---------G 245
            ::..:.::.||:.:..:       ..||...:....  ::..|...|.:...:.|         |
  Rat   229 LMIYAFVEVGGYESFTEKYMNAIPSVVEGDNLTISPKCYTPQPDSFHIFRDAVTGDIPWPGTAFG 293

  Fly   246 M-VTYLSLYGVNQTQVQRLLSVRNLKSAQSALWWNLPILGMLSFSTIFSGLSIFYYYRDCDPLLK 309
            | :|.|..:.:||..|||.|..:|:...::|    ..:.|.|..      |.||:...   |.:.
  Rat   294 MPITALWYWCINQVIVQRCLCGKNMSHVKAA----CIVCGYLKL------LPIFFMVM---PGMI 345

  Fly   310 GRIDKRDQIMPLFALETMGQ-----------YP---------GLCGLFVSGIFSASLSTISSAVT 354
            .||...|.:..:...|.:.|           ||         ||.||.:|.:.::.:|:::|...
  Rat   346 SRILYTDMVACVVPSECVKQCGVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSIFN 410

  Fly   355 SLSAV-TLEDYLKPLYKAIFKRTLIDSKSTMPTKIVACIFGLLCIGLAFVAGSMGG-VLQASLTI 417
            |.|.: |::.|.|...||..:..||..:..:...||..|     :.:..|..|.|| ::..:..|
  Rat   411 SASTLFTMDLYTKIRKKASERELLIAGRLFVSVLIVTSI-----LWVPIVEVSQGGQLIHYTEAI 470

  Fly   418 FGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVSFWMGFGGPKPKPVTLEFS--TAGCENAT 480
            ...:|.|:.|:|.:.:...|.|::|...|.:|.|::....         :..|||  |..|
  Rat   471 SSYLGPPIAAVFLVAIFCKRVNEQGAFWGLMVGLVLGLIR---------MIAEFSYGTGSC---- 522

  Fly   481 AVMARAIELSSKSSGVVIEPDYFWLYRISYLWLSVIGFLIAVV----VGYFSS-IVLAH----CG 536
                    |:..|...||       ..:.||:.::|.|.::::    |.|.:. |...|    |.
  Rat   523 --------LAPSSCPKVI-------CGVHYLYYAIILFFVSILVILGVSYLTKPIPDVHLYRLCW 572

  Fly   537 KAENAE---IYLD-KSRKQLDYDLFAPMLSRRWRRHKEEQDQTAQDETLTKLT 585
            ...|:|   |.|| :.|::.:.|.            :.|:|||.:.....|.|
  Rat   573 SLRNSEEERIDLDAEDREENEADA------------RTEEDQTEKPRGCLKKT 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	126/574 (22%)
Slc5a4	NP_001099853.1	SLC5-6-like_sbd	38..671	CDD:294310	142/638 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810