DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10444 and Slc5a9

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_663526.3	Gene:	Slc5a9 / 230612	MGIID:	2140201	Length:	685	Species:	Mus musculus

Alignment Length:	572	Identity:	126/572 - (22%)
Similarity:	234/572 - (40%)	Gaps:	107/572 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WDAAVLITILVISALIGIY--YRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSAISLMGVS 71
            :|..|::...|....:||:  .|.:.|   |...|.:|.:|||.:|:..|||:|.:.:...:|::
Mouse    32 YDIVVVVIYFVFVLAVGIWSSIRASRG---TVGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLA 93

  Fly    72 NE---------SYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLSA 127
            ..         .:|:...|.::.:.::         |:||:......::.:||::||| ..|:..
Mouse    94 GTGAAGGLAVGGFEWNATFLLLALGWI---------FVPVYIAAGVVTMPQYLKKRFG-GQRIQV 148

  Fly   128 SLAFTVQMVLY----MGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQ 188
            .:: .:.::||    :...:::.||.::...|.:..::.|::.:|...|:..|||.||:.||..|
Mouse   149 YMS-VLSLILYIFTKISTDIFSGALFIQMALGWNLYLSTVILLVVTAVYTIAGGLTAVIYTDALQ 212

  Fly   189 SFLMFAAIYAVIAVSAIKAG---GFAAIWDVAVERGRVNFIEFSLD-PTVRH----------TWW 239
            :.:|......::.:...:.|   |...::..|:....|......|. |...|          .|.
Mouse   213 TVIMVGGALVLMFLGFQEVGWYPGLQQLYRQAIPNTTVPNTTCHLPRPDAFHMLRDPVNGDIPWP 277

  Fly   240 SLIIGGMVTYLSLYGVNQTQVQRLLSVRNLKSAQ--SALWWNLPILGMLSFSTIFSGLSIFYYYR 302
            .||.|..|.....:..:|..|||.|:.:||..|:  |.|...|.||.|  |..:..|:.....|.
Mouse   278 GLIFGLTVLATWCWCTDQVIVQRSLAAKNLSHAKGGSVLGGYLKILPM--FFIVMPGMISRALYP 340

  Fly   303 D---------CDPLLKGRIDKRDQIMPLFALETMGQYP-GLCGLFVSGIFSASLSTISSAVTSLS 357
            |         |..:...|:...:...|...:..|   | ||.||.::.|.:|.:|:::|...|.|
Mouse   341 DEVACVDPDICQRVCGARVGCSNIAYPKLVMALM---PVGLRGLMIAVIMAALMSSLTSIFNSSS 402

  Fly   358 AVTLEDYLKPLYKAIFKRTLIDSKSTMPTKIVACIFGLLCIGLAFV------AGSMGGVLQASLT 416
            .:...|..:.     |:|    ..|.....:|..:|.:..:.::.:      :.:.|.:.....:
Mouse   403 TLFAIDVWQR-----FRR----QASEQELMVVGRLFVVFLVVISILWIPIIQSSNSGQLFDYIQS 458

  Fly   417 IFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVSFWMGFGGPKPKPVTLEF--STAGC--- 476
            |...:..|:.|:|.|.:...|.|:.|...|.:..|:|....         :.|||  |...|
Mouse   459 ITSYLAPPITALFLLAIFCKRVNEPGAFWGLMFGLVVGILR---------MILEFSYSAPACGEM 514

  Fly   477 ENATAVMARAIELSSKSSGVVIEPDYFWLYRISYLWLSVIGFLIAVVVGYFS 528
            :...||:                .|:.:||  ..|.|..:..:|.||:.:|:
Mouse   515 DRRPAVL----------------KDFHYLY--FALLLCGLTAIIIVVISFFT 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	126/572 (22%)
Slc5a9	NP_663526.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SLC5-6-like_sbd	45..685	CDD:382020	123/559 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..616
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6277
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840