DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10444 and Slc5a8

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_663398.2	Gene:	Slc5a8 / 216225	MGIID:	2384916	Length:	611	Species:	Mus musculus

Alignment Length:	572	Identity:	239/572 - (41%)
Similarity:	351/572 - (61%)	Gaps:	27/572 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VGTFDAWDAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSAISL 67
            :|:|..||..|...:|:|||.|||||.:.||.|:|::::||..:||:..||:.||.||||||:::
Mouse     7 IGSFVVWDYVVFAGMLLISAAIGIYYAFAGGGQQTSKDFLMGGRSMSAVPVALSLTASFMSAVTV 71

  Fly    68 MGVSNESYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLSASLAFT 132
            :|...|.|.||.||.:..|.|.....|:|..|||||||:..||.|||||.||.:..||..::.|.
Mouse    72 LGTPAEVYRFGAIFSIFVITYFFVVVISAEVFLPVFYRLGITSTYEYLELRFNRCIRLCGTILFI 136

  Fly   133 VQMVLYMGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQSFLMFAAIY 197
            ||.:||.||.:|||||||..|||.....|:|..|:|||||.||||||||:.|||||..:|.|...
Mouse   137 VQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFA 201

  Fly   198 AVIAVSAIKAGGFAAIWDVAVERGRVNFIEFSLDPTVRHTWWSLIIGGMVTYLSLYGVNQTQVQR 262
            :||..::|...|...|...|...||:||..|..:|..|||:|:::|||..|:.::|||||:||||
Mouse   202 SVIIQASITQHGINKILSDAFNGGRLNFWNFDPNPLQRHTFWTIVIGGTFTWTTIYGVNQSQVQR 266

  Fly   263 LLSVRNLKSAQSALWWNLPILGMLSFSTIFSGLSIFYYYRDCDPLLKGRIDKRDQIMPLFALETM 327
            .:|.::...|:.:|:.||..|.::...:||.||:::..||:|||....::...||:||...|:.:
Mouse   267 YISCKSRLHAKLSLYVNLVGLWVILTCSIFCGLALYSRYRECDPWTSKKVSAIDQLMPYLVLDIL 331

  Fly   328 GQYPGLCGLFVSGIFSASLSTISSAVTSLSAVTLEDYLKPLYKAIFKRTLIDSKSTMPTKIVACI 392
            ..|||:.||||:..:|.:|||:||::.:|:|||:||.:||.:|::.:::|     :..::.::.:
Mouse   332 KNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFKSLSEKSL-----SWISQGMSVL 391

  Fly   393 FGLLCIGLAFVAGSMGGVLQASLTIFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVSFWM 457
            :|.||||:|.:|..||.:|||:|:|||:||||||.:|:||:....:|..|.|.|.|....:|.|:
Mouse   392 YGALCIGMAALASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSIGALTGLLAGFAISLWV 456

  Fly   458 GFGG----PKPK---PVTLEFSTAGC---ENATAVMARAIELSSKSSGVVIE-----PDYFWLYR 507
            |.|.    |.|:   |:.||  |.||   .|.:..|: ..|:...:|...|.     |.....|.
Mouse   457 GIGAQLYPPLPERTLPLPLE--TYGCNITHNGSDWMS-TTEMPFSTSAFQIHNAERTPLMDNWYS 518

  Fly   508 ISYLWLSVIGFLIAVVVGYFSSIVLAHCGKAENAE--IYLDKSRKQLDYDLF 557
            :|||:.|.||.|..:.||..  |.|:..|:.:|.:  ..|.|.....::|:|
Mouse   519 LSYLYFSTIGTLTTLFVGIL--ISLSTGGRKQNLDPRFLLTKQDFLSNFDVF 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	229/536 (43%)
Slc5a8	NP_663398.2	SLC5sbd_SMCT1	7..549	CDD:271402	234/551 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	366	1.000	Domainoid score	I922
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1711
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm8902
orthoMCL	1	0.900	-	-		OOG6_101204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6277
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.800