DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10444 and SLC5A11

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001339171.1	Gene:	SLC5A11 / 115584	HGNCID:	23091	Length:	675	Species:	Homo sapiens

Alignment Length:	510	Identity:	129/510 - (25%)
Similarity:	221/510 - (43%)	Gaps:	102/510 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSA---ISL---- 67
            |.|||:...:....:|: :.....|:.|.:.|.:|...|..:||..||.||.:.:   |.|
Human    28 DIAVLVLYFLFVLAVGL-WSTVKTKRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSG 91

  Fly    68 --MGVSNESYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLSASLA 130
              .|:|..:||...:|.|:.:|::         |||::...:.|::.|||.:||| ..|:...||
Human    92 AATGISVSAYELNGLFSVLMLAWI---------FLPIYIAGQVTTMPEYLRKRFG-GIRIPIILA 146

  Fly   131 FTVQMVLYM--------GIALYAPALALEAVTGIHRSMAIVVIGL--VCTFYSTLGGLKAVLITD 185
                 |||:        .:.:||.|:.::  ..:|..:.:.::||  :...|:..|||.||:.||
Human   147 -----VLYLFIYIFTKISVDMYAGAIFIQ--QSLHLDLYLAIVGLLAITAVYTVAGGLAAVIYTD 204

  Fly   186 VFQSFLMFAAIYAVIAVSAIKAGGFAAIWD-----VAVERG--------RVNFIEFSLDPTVRHT 237
            ..|:.:|......::..|....||...:.:     :|..|.        |.:......||.....
Human   205 ALQTLIMLIGALTLMGYSFAAVGGMEGLKEKYFLALASNRSENSSCGLPREDAFHIFRDPLTSDL 269

  Fly   238 WWSLIIGGM-VTYLSLYGVNQTQVQRLLSVRNLKSAQ-----SALWWNLPILGMLSFSTIFSGLS 296
            .|..::.|| :..|..:..:|..|||.|:.:||..|:     :|....||:     |..:|.|:.
Human   270 PWPGVLFGMSIPSLWYWCTDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPL-----FIMVFPGMV 329

  Fly   297 IFYYYRD----CDPLLKGRIDKR-----DQIMPLFALETMGQYPGLCGLFVSGIFSASLSTISSA 352
            ....:.|    .||.:..:|...     |...|...||.:.  .||.||.::.:.:|.:|:::|.
Human   330 SRILFPDQVACADPEICQKICSNPSGCSDIAYPKLVLELLP--TGLRGLMMAVMVAALMSSLTSI 392

  Fly   353 VTSLSAV---TLEDYLKPLYKAIFKRTLIDSKSTMPTKIVACIFGLLCI-----GLAFVAGSMGG 409
            ..|.|.:   .|.::|:|  :|..|..:          ||..:|.||.:     .:..|..|.||
Human   393 FNSASTIFTMDLWNHLRP--RASEKELM----------IVGRVFVLLLVLVSILWIPVVQASQGG 445

  Fly   410 VLQASL-TIFGVVGGPLLAIFTLGVCTTRSNQR--------GVLLGFLVSLIVSF 455
            .|...: :|...:..|:..:|.:|....|:|::        |:||| ||.|::.|
Human   446 QLFIYIQSISSYLQPPVAVVFIMGCFWKRTNEKGAFWGLISGLLLG-LVRLVLDF 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	129/510 (25%)
SLC5A11	NP_001339171.1	SLC5sbd_SGLT6	28..675	CDD:271381	129/510 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910