DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10444 and Slc5a5

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_443215.2	Gene:	Slc5a5 / 114613	RGDID:	69267	Length:	618	Species:	Rattus norvegicus

Alignment Length:	595	Identity:	213/595 - (35%)
Similarity:	321/595 - (53%)	Gaps:	37/595 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TFDAWDAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSAISLMG 69
            ||.|||..|..|:|::|..||::.....|.|::..::....:.:...||..||.||||||:.::|
  Rat    11 TFGAWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVGLSLAASFMSAVQVLG 75

  Fly    70 VSNESYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLSASLAFTVQ 134
            |..|:..:|..|..:....:|::.:.|:.|||:|||:..||.|:|||.||.:|.||..:|.:.|.
  Rat    76 VPAEAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLVA 140

  Fly   135 MVLYMGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQSFLMFAAIYAV 199
            .:||.||.:|||||.|..|||:....:::..|::||.|:|:||:|||:.|||||..:|....:.:
  Rat   141 TMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVMLVGFWVI 205

  Fly   200 IAVSAIKAGGFAAIWDVAVERGRVNFIEFSLDPTVRHTWWSLIIGGMVTYLSLYGVNQTQVQRLL 264
            :|...|..||...:..:|....|:|.::|..||..|:|:|:.|:||.:.:||:|||||.||||.:
  Rat   206 LARGVILLGGPRNMLSLAQNHSRINLMDFDPDPRSRYTFWTFIVGGTLVWLSMYGVNQAQVQRYV 270

  Fly   265 SVRNLKSAQSALWWNLPILGMLSFSTIFSGLSIFYYYRDCDPLLKGRIDKRDQIMPLFALETMGQ 329
            :......|:.||..|...|.::..|....|:.:|.||:||||||.|||...||.|||..|:....
  Rat   271 ACHTEGKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRISAPDQYMPLLVLDIFED 335

  Fly   330 YPGLCGLFVSGIFSASLSTISSAVTSLSAVTLEDYLKPLYKAIFKRTLIDSKSTMPTKIVACIFG 394
            .||:.|||::..:|.:|||.|:::.:::|||:||.:||....:..|.|:     ..:|.::.|:|
  Rat   336 LPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPGLAPRKLV-----FISKGLSFIYG 395

  Fly   395 LLCIGLAFVAGSM-GGVLQASLTIFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVSFWMG 458
            ..|:.:|.::..: |||||.|.|:.||:.||||..||||:.....|..|||.|....|.||.|:.
  Rat   396 SACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLAAGLAVSLWVA 460

  Fly   459 FGGPKPKP-----VTLEFSTAGCENATAVM--------ARAIELSSKSSGVVIEPDYFWLYRISY 510
            .|.....|     ..|..|.|||.|.:.::        :..|..|...:|.....|.|  |.|||
  Rat   461 VGATLYPPGEQTMGVLPTSAAGCTNDSVLLGPPGATNASNGIPSSGMDTGRPALADTF--YAISY 523

  Fly   511 LWLSVIGFLIAVVVGYFSSIVLAHCGKAENAEIYL--DKSRKQLDYDLFAPMLSRRWRRHKEEQD 573
            |:...:|.|..::.|...|              ||  ...|..|...|....|:|:......::|
  Rat   524 LYYGALGTLTTMLCGALIS--------------YLTGPTKRSSLGPGLLWWDLARQTASVAPKED 574

  Fly   574 QTAQDETLTK 583
            ....:|:|.|
  Rat   575 TATLEESLVK 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	199/535 (37%)
Slc5a5	NP_443215.2	SLC5sbd_NIS	15..549	CDD:271393	201/554 (36%)
Slc5a5	NP_443215.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	371	1.000	Domainoid score	I866
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1652
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9146
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870