DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10444 and slc5a3a

DIOPT Version :9

Sequence 1:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001153309.1	Gene:	slc5a3a / 100004287	ZFINID:	ZDB-GENE-090312-3	Length:	671	Species:	Danio rerio

Alignment Length:	569	Identity:	139/569 - (24%)
Similarity:	233/569 - (40%)	Gaps:	93/569 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TFDAWDAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSAISLMG 69
            |.:|.|..|:....|:....|.:..:...: .|...|.:|.:||..|.:..||..|.:.:...:|
Zfish     4 TMEAADIIVVAMYFVLVLCFGFFSMWRANR-GTVSGYFLAGRSMNWFVIGASLFVSNIGSEHFIG 67

  Fly    70 VSNESYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLS---ASLAF 131
            ::......|..........:|...:..:.|:||:......::.|||.:||| ..||.   |||..
Zfish    68 LAGSGAASGLAVGAWEFNAILLLQLLGWVFIPVYIHSGVYTMPEYLSKRFG-GNRLKIYFASLTL 131

  Fly   132 TVQMVLYMGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQSFLMFAAI 196
            .:.:...:.:.||:.||.::...|.:..::|:::..:....:..|||.||:.||..|:|||.:..
Zfish   132 LLYIFTKLSVDLYSGALFIQESLGWNLYLSIILLITLTALLTVTGGLVAVIYTDTLQAFLMISGA 196

  Fly   197 YAVIAVSAIKAGGFAA-----------IWDVAVERG-------RVN-------FIEFSLDPTVRH 236
            ..::|:|.:|.||...           |..:.:|..       .||       .:...||..:
Zfish   197 LCLMAISLVKVGGLEGLRTKYMNALPNITFITLENNLTYSNSCHVNPKADSFKLLRSPLDKDL-- 259

  Fly   237 TWWSLIIGGMVTYLSLYGVNQTQVQRLLSVRNLKSAQSA--LWWNLPILGMLSFSTIFSGLSIFY 299
            .|.:.::|.....:..:..:|..|||:|:.||:..|:.:  |...|.:|.|  |..:..|:....
Zfish   260 PWPAFLLGQTPASIWYWCADQVIVQRVLAARNIAHAKGSTLLAGVLKVLPM--FIIVIPGMISRV 322

  Fly   300 YYRD---------CDPLLKGRIDKRDQIMPLFALETMGQYP-GLCGLFVSGIFSASLSTISSAVT 354
            .:.|         |..:...|....:...|...:..|   | ||.||.::.:.:|.:|.:.|...
Zfish   323 LFADELACIGPEHCMQVCNSRAGCTNTAYPRLVMNIM---PVGLRGLMMAVMLAALMSDLDSIFN 384

  Fly   355 SLSAV-TLEDYLKPLYKAIFKRTLIDSKSTMPTKIVACIFGLLCIGLA-----FVAGSMGGVLQA 413
            |.|.: ||:     :||.|  |....||..|   :|..:|.:|.:.::     ||....||  |.
Zfish   385 SASTIFTLD-----IYKMI--RHQASSKELM---VVGRLFVVLIVAISIAWVPFVIEMQGG--QM 437

  Fly   414 SLTIFGV---VGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVSFWMGFGGPKPKPVTLEFSTAG 475
            .|.|..|   :..|:.|:|.|||...|.|:.|           :||.||.|.....|.|
Zfish   438 FLYIQEVSDYLTPPIAALFLLGVLWKRCNETG-----------AFWGGFVGLILGIVRL------ 485

  Fly   476 CENATAVMARAIELSSKSSGVVIEPDYFWLYRISYL-WLSVIGFLIAVV 523
               ..|.:.|..:..|.........|..::|..:.| |:|  ||::.||
Zfish   486 ---ILAFVYREPDCDSVDDRPAFIKDVHFMYVAAVLFWVS--GFVMVVV 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	137/565 (24%)
slc5a3a	NP_001153309.1	SLC5-6-like_sbd	9..671	CDD:294310	137/564 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810