DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8908 and Abca1

DIOPT Version :10

Sequence 1:NP_611464.3 Gene:CG8908 / 37293 FlyBaseID:FBgn0034493 Length:1626 Species:Drosophila melanogaster
Sequence 2:XP_038965774.1 Gene:Abca1 / 313210 RGDID:631344 Length:2263 Species:Rattus norvegicus


Alignment Length:1804 Identity:434/1804 - (24%)
Similarity:748/1804 - (41%) Gaps:411/1804 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   124 YVGIEFDDSFSDINELPINVTVGLRFPL-HLRKNPKM---VWDNTSILKHSKMDVDYYQVEGFLV 184
            :.||.|.....|..|||.:|...:|..: ::.:..|:   .||...  :....:...|...||..
  Rat   533 WAGIVFTGITPDSVELPHHVKYKIRMDIDNVERTNKIKDGYWDPGP--RADPFEDMRYVWGGFAY 595

  Fly   185 VQAKLSEALIRAKNEAVVLPEVILQHYPDVAEVDRLDNRVALGGV-LFLPVT--ISAAYLAQMIV 246
            :|..:.:|:||..........|.:|..|....||.:..||....: ||:.:.  .|.|.:.:.||
  Rat   596 LQDVVEQAIIRVLTGTEKKTGVYVQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKSIV 660

  Fly   247 MERRDHLRDMLELMGVRAWIYWLSWFLVAFLLLSIPTVFMVLLLK-WRYFSLSDSSLVLFFLLVY 310
            .|:...|::.:.:||:...|.|.|||:.:.:.|.:....:|::|| ......||.|:|..||.|:
  Rat   661 YEKEARLKETMRIMGLDNGILWFSWFISSLIPLLVSAGLLVIILKLGDLLPYSDPSVVFVFLSVF 725

  Fly   311 NLEVLTSAFMISSFFSDT------VGVQVAIVIVHLIGCLPWRLLLMGYVPTLPRTIFVCLFLNS 369
            .:..:...|:||:.||.|      .|:....:.:..:.|:.|:    .|| .....||..|....
  Rat   726 AVVTILQCFLISTLFSRTNLAAACGGIIYFTLYLPYVLCVAWQ----DYV-GFSIKIFASLLSPV 785

  Fly   370 SLAMGLQQFIKSENLRLGLHWTYLFERTDWDEFVHLGPILLFMLFGCLLRILVLAYMEQLRSYQ- 433
            :...|.:.|...|...:|:.|..||:....::..:|...:..|||...:..::..|:|.:...| 
  Rat   786 AFGFGCEYFALFEEQGIGVQWDNLFKSPVEEDGFNLTTSVSMMLFDTFIYGVMTWYIEAVFPGQY 850

  Fly   434 --NRKWYFPVQPSFWCRWNRRPRSDDFDVEGQETGIRGHP--------------------LIVRA 476
              .|.||||...|:|.              |:|...:.||                    |.|..
  Rat   851 GIPRPWYFPCTKSYWF--------------GEEIDEKSHPGSSQKGASEICMEEEPTHLKLGVSI 901

  Fly   477 RNIEKVFNEW--IAVKDLNLNFYQDEITVFLGHNDSGKSTILMLLAGFLRPSAGEITINGYDLAT 539
            :|:.||:.:.  :||..|.||||:.:||.|||||.:||:|.:.:|.|...|::|...|.|.|:.:
  Rat   902 QNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRS 966

  Fly   540 NQRKARQSMCICPQPNVLFEKVNARWHLQFYCRLKGLNRQEASAETDKY-LEIGRLQDFANTKVK 603
            .....||::.:|||.||||:.:....|:.||.|||||:.:...||.::. |::|.......:|..
  Rat   967 EMNSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPPSKLKSKTS 1031

  Fly   604 NLPSGIKRMLMLCCNLCGNSKILLLDEPGTSMDPAMRSNMWDLLRRERKGRCIIMATHNMNEAEV 668
            .|..|::|.|.:.....|.||:::||||...:||..|..:|:||.:.|:||.||::||:|:||::
  Rat  1032 QLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADI 1096

  Fly   669 VADQIVVLCDAQVIGYGTTGFLTQIAGTGSSYLLICTKMD---------------TCI------- 711
            :.|:|.::...::...|::.||....|||  |.|...|.|               :|:       
  Rat  1097 LGDRIAIISHGKLCCVGSSLFLKNQLGTG--YYLTLVKKDVESSLSSCRNSSSTVSCLKKVVPEL 1159

  Fly   712 ----------------------VAEVTNFLQIRFPDIKLHNEFSIYVTYELPTKYVQQ--YAALF 752
                                  |:.::|.::....:.:|..:....:||.||.:..::  :..||
  Rat  1160 PAAGQSGGRGGEVQRLVALTQDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELF 1224

  Fly   753 LELEEALGELNLAEISVCAPTLGSVFLQMGEEM----------------RQSWN----------- 790
            .|:::.|.:|.::...:...||..:||::.||.                |:::.           
  Rat  1225 HEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLHPFTE 1289

  Fly   791 ------RISSFDLLSSPSPMLSLLNLLPTFEVREDDGRVKCCNQWRAIVEKKRLFTLRHQK-FYC 848
                  ..|..|..|..:.:||.::...:::::   |......|:.|::.|:.|...|.:| |:.
  Rat  1290 DDAVDPNDSDLDPESRETDLLSGMDGKGSYQLK---GWKLTQQQFVALLWKRLLIARRSRKGFFA 1351

  Fly   849 MIIATPIIICLLIISFSIFI---------------------FL-----VDHHLSELL-------- 879
            .|:...:.:|:.:: ||:.:                     |:     .|....|||        
  Rat  1352 QIVLPAVFVCIALV-FSLIVPPFGKYPNLELQPWMYNEQYTFVSNDAPEDMGTQELLNALTKDPG 1415

  Fly   880 -----------------------------VTDLSIYPKAVFVIDSPAEGNRFERHYMANVI---- 911
                                         .|.:.::....:.:.:|:...:.....:..::    
  Rat  1416 FGTRCMEGNPIPNTPCLVGEEDWTTGPVPQTLMDLFQNGNWTMKNPSPSCQCSSDKIKKMLPVCP 1480

  Fly   912 -GQGG------------TVRSTSGTPIDDYL-------LAEMESDQVKV---------------- 940
             |.||            .:::.:|..|.|||       :|:...::|.|                
  Rat  1481 PGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQIIAKSLKNKVWVNEFRYGGFSLGVSDSQ 1545

  Fly   941 -------------QHTFLAGATFDSNA-----------------NSIIAWSNNKLKHGSALSMGL 975
                         |...|...|.||:|                 |::..|.|||..|..:..:.:
  Rat  1546 ALPPSQEVNNAIKQMKKLLKLTKDSSADRFLSSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNV 1610

  Fly   976 VYAAI-------GQELAKLDIRIVNKPYQDTVQQAVRGLIYASTIE--FAVLVFHYLVLGTAIFA 1031
            :..||       |:..::..|...|.|...|.||.....:..::::  .::.|...:....|.|.
  Rat  1611 INNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFV 1675

  Fly  1032 VLPIVERRSKVQHQQFSSGMSRSTYWLSHLSWDYCFYIAMILPLIVVAGITI---------GSVL 1087
            |..|.||.||.:|.||..|:....||||:..||.|.|   ::|..:|..|.|         .:.|
  Rat  1676 VFLIQERVSKAKHLQFICGVKPVIYWLSNFVWDMCNY---VVPATLVVIIFICFQQKSYVSSTNL 1737

  Fly  1088 PVI-VQLLAFGFSAISFTY----LLCLMSNDFGKMFSIILYINMIGVLALFIHPKSPQTRY---- 1143
            ||: :.||.:|:|.....|    :..:.|..:..:.|:.|:|.:.|.:|.|:.......::    
  Rat  1738 PVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKFNDIN 1802

  Fly  1144 AVIESVLLVHPHYSLCCGMYEAIR----------------MSTFSLKQLPYLIFSGAAYLTIVVF 1192
            .:::||.|:.||:.|..|:.:.::                :|..|...:...:|:.|  :..|||
  Rat  1803 DILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMA--VEGVVF 1865

  Fly  1193 AWVPRRLNYVFKSIRNEKI---YPSYKDEDKEVDKMRRRLAYLTTAHYAFFPLILKNLSKRY--G 1252
            ..|...:.|.| .||...:   .|...|||::|.:.|:|:......:..   |.:|.|:|.|  .
  Rat  1866 FLVTVLIQYRF-FIRPRPVKARLPPLNDEDEDVRRERQRILEGGGQNDI---LEIKELTKIYRRK 1926

  Fly  1253 SFVAVRSLTLDLNPFECVGLLGRNGSGKSSIFRMIVGMESITVGSIHIKGYSLKTRPKDASRHVG 1317
            ...||..:.:.:.|.||.||||.||:||:|.|:|:.|..::|.|...:...|:.:...:..:::|
  Rat  1927 RKPAVDRICVGIPPGECFGLLGVNGAGKTSTFKMLTGDTAVTRGDALLNKNSILSNIHEVHQNMG 1991

  Fly  1318 FCPRELMLLSFMTGKDALRFCCLINGIRREYIKSLVASLAECFELVPHMNKRISTYSNGTKRKLM 1382
            :||:...:...:||::.|.|..|:.|:..:.:..:.........||.:..|..|.||.|.||||.
  Rat  1992 YCPQFDAITELLTGREHLEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLS 2056

  Fly  1383 IAMGTL-APSLMCLDEPTAGVDMHAKYEIWSILDGIRQGGRSILLTTHNLEECEFLCTNVGIMDH 1446
            .|:..: .|.::.|||||.|:|..|:..:|:....|.:.|||::||:|::||||.|||.:.||.:
  Rat  2057 TAIALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIIKEGRSVVLTSHSMEECEALCTRMAIMVN 2121

  Fly  1447 GSLLCYGSLSRLKHRFNMGIFVKVKMGTRAEMDDERDNWMQITMMPPNDSEMGSTVGARRMMLAH 1511
            |...|.||:..||:||..|..:.|::.                         ||           
  Rat  2122 GRFRCLGSVQHLKNRFGDGYTIVVRIA-------------------------GS----------- 2150

  Fly  1512 LLRHHNPPVEPVKKSRTSRAQPDTTNSELNMRKDYEALLQELEEVFKKDHPYSTVSEKYSYRGMI 1576
                 ||.::||                              :|.|....|.|.:.||  :|.|:
  Rat  2151 -----NPDLKPV------------------------------QEFFGLAFPGSVLKEK--HRNML 2178

  Fly  1577 TFCIPRGQIKWSAIFEYMENLKDEMQILYYSVSHTTFQDVFMKFVRKQN 1625
            .:.:|......:.||..:...|..:.|..||||.||...||:.|.:.|:
  Rat  2179 QYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQS 2227

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8908NP_611464.3 rim_protein <124..1626 CDD:130324 434/1804 (24%)
Abca1XP_038965774.1 rim_protein 1..2238 CDD:130324 434/1804 (24%)

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