DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8908 and ABCA5

DIOPT Version :10

Sequence 1:NP_611464.3 Gene:CG8908 / 37293 FlyBaseID:FBgn0034493 Length:1626 Species:Drosophila melanogaster
Sequence 2:NP_061142.2 Gene:ABCA5 / 23461 HGNCID:35 Length:1642 Species:Homo sapiens


Alignment Length:1805 Identity:409/1805 - (22%)
Similarity:746/1805 - (41%) Gaps:386/1805 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 KTQSSICLLWLVICKTARFQFSNTLTSVIIIVGPIVVFLVYAATALFREPQEETSVKYPPVN-IT 72
            :|::.:...:|:.|:|.:......|..:..:...|::.:::..    ::.:|..:::..|:: .|
Human    13 QTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPN----KKYEEVPNIELNPMDKFT 73

  Fly    73 TKVPYIYYSPENLVLAAVIEDVV--HDLKAVGSKAFASASELNKALIGKDTYGYVGIEFDDSFSD 135
            .....:.|:|...:.:::::.|.  |....:.::.:.:..|:..:.:.|.: .:||:.|.||.| 
Human    74 LSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPS-NFVGVVFKDSMS- 136

  Fly   136 INELPINVTVGLRFPLHLRKNPKMVWDNTSILKHSK------MDVDYYQVEGFLVVQAKLSEALI 194
                           ..||..|.|: ..:||...|:      .:...|...||.|:||.:..|:|
Human   137 ---------------YELRFFPDMI-PVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASIDAAII 185

  Fly   195 RAK-----------NEAVVLPEVILQHYPDVAEVDRLDNRVALGGVLFLPVTIS--AAYLAQMIV 246
            :.|           .:||::.|..      |.|:|.....|.|   ::|.:..|  ..:||..||
Human   186 QLKTNVSLWKELESTKAVIMGETA------VVEIDTFPRGVIL---IYLVIAFSPFGYFLAIHIV 241

  Fly   247 MERRDHLRDMLELMGVRAWIYWLSWFLVAFLLLSIPTVFMVLLLKWRYFSLSDSSLVLFFL-LVY 310
            .|:...:::.|::||:....:||||.|:...|:.:.::.|.::..........||:|:|.| .:|
Human   242 AEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLY 306

  Fly   311 NLEVLTSAFMISSFF--SDTVGVQVAIVIVHLIGCLPWRLLLMGYVPTLPRTIFVCL---FLNSS 370
            .|..:..|.|::..|  |..||: |...:....|.:...::|   :.:.|::: |.|   |.:.:
Human   307 GLSSVFFALMLTPLFKKSKHVGI-VEFFVTVAFGFIGLMIIL---IESFPKSL-VWLFSPFCHCT 366

  Fly   371 LAMGLQQFIKSENLRLGLHWTYLFERTDWDEFVHLGP----ILLFML-FGCLLRILVLAYMEQL- 429
            ..:|:.|.:..|:...|..::.|          ..||    |.:.|| ...:..:|:..|::|: 
Human   367 FVIGIAQVMHLEDFNEGASFSNL----------TAGPYPLIITIIMLTLNSIFYVLLAVYLDQVI 421

  Fly   430 ---RSYQNRKWYFPVQPSFWCRWNR--------------------RPRSDDFDVEGQETGIRGHP 471
               ...:....|| ::||:|.:..|                    .|.|.:|  .|:|.      
Human   422 PGEFGLRRSSLYF-LKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEF--VGKEA------ 477

  Fly   472 LIVRARNIEKVFNE----WIAVKDLNLNFYQDEITVFLGHNDSGKSTILMLLAGFLRPSAGEITI 532
              :|...|:|.:.:    ..|:::|:.:.|:.:||..|||:.:||||::.:|.|...||.|..:|
Human   478 --IRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI 540

  Fly   533 NGYDLA--TNQRKARQSMCICPQPNVLFEKVNARWHLQFYCRLKGLNRQEASAETDKYLEIGRLQ 595
            .|:.::  ....:||:.:.||||.::.|:.:....:|.....:||:.......|..|.|....:|
Human   541 YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQ 605

  Fly   596 DFANTKVKNLPSGIKRMLMLCCNLCGNSKILLLDEPGTSMDPAMRSNMWDLLRRERKGRCIIMAT 660
            ...:.:.|.|..|.||.|.|...:.||.||||||||...|||..|..:|:||:..:..|..:.:|
Human   606 TIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFST 670

  Fly   661 HNMNEAEVVADQIVVLCDAQVIGYGTTGFLTQIAGTGSSYLLICTKMDTCIVAEVTNFLQIRFPD 725
            |.|:||:::||:..|:....:...|::.||....|.|....:...|.  |....:::.::...|.
Human   671 HFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKY--CATESLSSLVKQHIPG 733

  Fly   726 IKLHNEFSIYVTYELPTKYVQQYAALFLELEEALGELNLAEIS--VCAPTLGSVFLQ-------- 780
            ..|..:....:.|.||.|.:.:::.||..|:   ...||..||  |...||..|||:        
Human   734 ATLLQQNDQQLVYSLPFKDMDKFSGLFSALD---SHSNLGVISYGVSMTTLEDVFLKLEVEAEID 795

  Fly   781 -----------MGEEMRQSWNRISSFDLLSSPSPMLSLLNLLPTFEVREDDGRVKCCNQWRA--- 831
                       :.|||..     .|||.:..     |||.|..|     ....|...:.|:.   
Human   796 QADYSVFTQQPLEEEMDS-----KSFDEMEQ-----SLLILSET-----KAALVSTMSLWKQQMY 845

  Fly   832 IVEKKRLFTLRHQKFYCMIIATPIIICLLIISFSIFIFLVDHHLSELLVTDLSIYPKAVFVI--D 894
            .:.|...|||:.:.   ..:.:.:::.|:..:..||:||| ||..:..|..:.:.|...|:.  |
Human   846 TIAKFHFFTLKRES---KSVRSVLLLLLIFFTVQIFMFLV-HHSFKNAVVPIKLVPDLYFLKPGD 906

  Fly   895 SPAEGNRFERHYMANVIGQGGTVRSTSGTPIDDYLLAEMESDQVKVQHTFLAGATFDSNANSIIA 959
            .|       ..|..:::     :::::.:.|.| |::...|..:.|  |.:..:.:.|.|     
Human   907 KP-------HKYKTSLL-----LQNSADSDISD-LISFFTSQNIMV--TMINDSDYVSVA----- 951

  Fly   960 WSNNKLKHGSALSM-----GLVYAAIGQEL----AKLDIRIVNKPY------QDTVQ-------Q 1002
                  .|.:||::     ..|:||:....    ..:.:.|::..|      .:|:|       |
Human   952 ------PHSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQ 1010

  Fly  1003 AVRGLIYASTIEFAVLVFHYLVLGTAIFAVLPIVERRSKVQH------QQFSSGMSRSTYWLSHL 1061
            .:..:::  .||   |.|...:||..:.|:.|.....:...|      |...||:..|.||:...
Human  1011 EITDIVF--KIE---LYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQA 1070

  Fly  1062 SWDY-CFYIAMILPLIVVAGITIG------SVLPVIVQLLAFGFSAISFTYLL------CLMSND 1113
            ..|. .|:|.:||.|..:.....|      ..|.|:..|:.:..|.|.|||:.      .|.:.:
Human  1071 VVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKE 1135

  Fly  1114 FGKMFSIILYINMIGV----------LALFIHPKSPQTRYAVIESVLLVHPHYSLCCGMYEAIRM 1168
            |......:..:..|.:          :|..:|       ||    ..::.|.|.|...:...|::
Human  1136 FWSFIYSVAALACIAITEITFFMGYTIATILH-------YA----FCIIIPIYPLLGCLISFIKI 1189

  Fly  1169 STFSLK----------QLPYLIFSGAAYLTIVVFAWVPRRLNYVFK-----SIRNEKIY------ 1212
            |..:::          :|...:.|  .||..|::.::   |.|..|     |||.:..:      
Human  1190 SWKNVRKNVDTYNPWDRLSVAVIS--PYLQCVLWIFL---LQYYEKKYGGRSIRKDPFFRNLSTK 1249

  Fly  1213 ---------PSYKDEDKEVDKMRRRLAYLTTAHYAFF--PLILKNLSKRYG-----------SFV 1255
                     |..:|||::|...|.::..|........  .:::.||.|.|.           ..|
Human  1250 SKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKV 1314

  Fly  1256 AVRSLTLDLNPFECVGLLGRNGSGKSSIFRMIVGMESITVGSIHIKGYSLKTRPKDAS-RHVGFC 1319
            |.:.::..:...|.:||||.||:|||:|..::||....|.|.:.:..||.:|...|.| :.:|:|
Human  1315 ATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYC 1379

  Fly  1320 PRELMLLSFMTGKDALRFCCLINGIRREYIKSLVASLAECFELVPHMNKRISTYSNGTKRKLMIA 1384
            |:...|....|.::.......:.|:....:|.:::.:....:|..|:.|.:.....|.||||..|
Human  1380 PQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFA 1444

  Fly  1385 MGTLA-PSLMCLDEPTAGVDMHAKYEIW-SILDGIRQGGRSILLTTHNLEECEFLCTNVGIMDHG 1447
            :..|. |.:..||||:.|:|..||..:| :|....:...|:.:||||.:||.|.:|..|.||..|
Human  1445 LSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSG 1509

  Fly  1448 SLLCYGSLSRLKHRFNMGIFVKVKMGTRAEMDDERDNWMQITMMPPNDSEMGSTVGARRMMLAHL 1512
            .|.|.|::..||.:|..|.|:::|:          .:|::                         
Human  1510 QLRCIGTVQHLKSKFGKGYFLEIKL----------KDWIE------------------------- 1539

  Fly  1513 LRHHNPPVEPVKKSRTSRAQPDTTNSELNMRKDYEALLQELEEVFKKDHPYSTVSEKYSYRGMIT 1577
                                    |.|:      :.|.:|::.:|      ...|.:.|:..::.
Human  1540 ------------------------NLEV------DRLQREIQYIF------PNASRQESFSSILA 1568

  Fly  1578 FCIPRGQIK-WSAIFEYMENLKDEMQILYYSVSHTTFQDVFMKFVRKQNQ 1626
            :.||:..:: .|..|..:|..|....|..||.|..|.:.||::..::|.:
Human  1569 YKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEE 1618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8908NP_611464.3 rim_protein <124..1626 CDD:130324 394/1685 (23%)
ABCA5NP_061142.2 rim_protein <84..1618 CDD:130324 398/1728 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1249..1268 4/18 (22%)

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