DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8908 and Abca1

DIOPT Version :10

Sequence 1:NP_611464.3 Gene:CG8908 / 37293 FlyBaseID:FBgn0034493 Length:1626 Species:Drosophila melanogaster
Sequence 2:XP_006537617.1 Gene:Abca1 / 11303 MGIID:99607 Length:2263 Species:Mus musculus


Alignment Length:1803 Identity:439/1803 - (24%)
Similarity:746/1803 - (41%) Gaps:409/1803 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   124 YVGIEFDDSFSDINELPINVTVGLRFPL-HLRKNPKM---VWDNTSILKHSKMDVDYYQVEGFLV 184
            :.||.|.....|..|||.:|...:|..: ::.:..|:   .||...  :....:...|...||..
Mouse   533 WAGIVFTGITPDSVELPHHVKYKIRMDIDNVERTNKIKDGYWDPGP--RADPFEDMRYVWGGFAY 595

  Fly   185 VQAKLSEALIRAKNEAVVLPEVILQHYPDVAEVDRLDNRVALGGV-LFLPVT--ISAAYLAQMIV 246
            :|..:.:|:||....:.....|.:|..|....||.:..||....: ||:.:.  .|.|.:.:.||
Mouse   596 LQDVVEQAIIRVLTGSEKKTGVYVQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKSIV 660

  Fly   247 MERRDHLRDMLELMGVRAWIYWLSWFLVAFLLLSIPTVFMVLLLK-WRYFSLSDSSLVLFFLLVY 310
            .|:...|::.:.:||:...|.|.|||:.:.:.|.:....:|::|| ......||.|:|..||.|:
Mouse   661 YEKEARLKETMRIMGLDNGILWFSWFVSSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVF 725

  Fly   311 NLEVLTSAFMISSFFSDT------VGVQVAIVIVHLIGCLPWRLLLMGYVPTLPRTIFVCLFLNS 369
            .:..:...|:||:.||..      .|:....:.:..:.|:.|:    .|| .....||..|....
Mouse   726 AMVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQ----DYV-GFSIKIFASLLSPV 785

  Fly   370 SLAMGLQQFIKSENLRLGLHWTYLFERTDWDEFVHLGPILLFMLFGCLLRILVLAYMEQLRSYQ- 433
            :...|.:.|...|...:|:.|..|||....::..:|...:..|||...|..::..|:|.:...| 
Mouse   786 AFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTAVSMMLFDTFLYGVMTWYIEAVFPGQY 850

  Fly   434 --NRKWYFPVQPSFWCRWNRRPRSDDFDVEGQETGIRGHP--------------------LIVRA 476
              .|.||||...|:|.              |:|...:.||                    |.|..
Mouse   851 GIPRPWYFPCTKSYWF--------------GEEIDEKSHPGSSQKGVSEICMEEEPTHLRLGVSI 901

  Fly   477 RNIEKVFNEW--IAVKDLNLNFYQDEITVFLGHNDSGKSTILMLLAGFLRPSAGEITINGYDLAT 539
            :|:.||:.:.  :||..|.||||:.:||.|||||.:||:|.:.:|.|...|::|...|.|.|:.:
Mouse   902 QNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRS 966

  Fly   540 NQRKARQSMCICPQPNVLFEKVNARWHLQFYCRLKGLNRQEASAETDKY-LEIGRLQDFANTKVK 603
            .....||::.:|||.||||:.:....|:.||.|||||:.:...||.::. |::|.......:|..
Mouse   967 EMSSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPPSKLKSKTS 1031

  Fly   604 NLPSGIKRMLMLCCNLCGNSKILLLDEPGTSMDPAMRSNMWDLLRRERKGRCIIMATHNMNEAEV 668
            .|..|::|.|.:.....|.||:::||||...:||..|..:|:||.:.|:||.||::||:|:||::
Mouse  1032 QLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADI 1096

  Fly   669 VADQIVVLCDAQVIGYGTTGFLTQIAGTGSSYLLICTKMD---------------TCI------- 711
            :.|:|.::...::...|::.||....|||  |.|...|.|               :|:       
Mouse  1097 LGDRIAIISHGKLCCVGSSLFLKNQLGTG--YYLTLVKKDVESSLSSCRNSSSTVSCLKKVVPGL 1159

  Fly   712 ----------------------VAEVTNFLQIRFPDIKLHNEFSIYVTYELPTKYVQQ--YAALF 752
                                  |:.::|.::....:.:|..:....:||.||.:..::  :..||
Mouse  1160 PAAGQSGGRGGEVQRLVALTQDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELF 1224

  Fly   753 LELEEALGELNLAEISVCAPTLGSVFLQMGEEM----------------RQSWN----------- 790
            .|:::.|.:|.::...:...||..:||::.||.                |:::.           
Mouse  1225 HEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLHPFTE 1289

  Fly   791 ------RISSFDLLSSPSPMLSLLNLLPTFEVREDDGRVKCCNQWRAIVEKKRLFTLRHQK-FYC 848
                  ..|..|..|..:.:||.::...:::::   |......|:.|::.|:.|...|.:| |:.
Mouse  1290 DDAVDPNDSDIDPESRETDLLSGMDGKGSYQLK---GWKLTQQQFVALLWKRLLIARRSRKGFFA 1351

  Fly   849 MIIATPIIICLLIISFSIFI---------------------FL-----VDHHLSELL-------- 879
            .|:...:.:|:.:: ||:.:                     |:     .|....|||        
Mouse  1352 QIVLPAVFVCIALV-FSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDMGTQELLNALTKDPG 1415

  Fly   880 -------------------VTDLSIYPKAVFVID------------SPA---EGNRFERHYMANV 910
                               ..|.:|.|....::|            |||   ..::.::......
Mouse  1416 FGTRCMEGNPIPDTPCLAGEEDWTISPVPQSIVDLFQNGNWTMKNPSPACQCSSDKIKKMLPVCP 1480

  Fly   911 IGQGG------------TVRSTSGTPIDDYLL--------------------------------- 930
            .|.||            .:::.:|..|.|||:                                 
Mouse  1481 PGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNSQ 1545

  Fly   931 ----AEMESDQVKVQHTFLAGATFDSNA-----------------NSIIAWSNNKLKHGSALSMG 974
                :...:|.:| |...|...|.||:|                 |::..|.|||..|..:..:.
Mouse  1546 ALPPSHEVNDAIK-QMKKLLKLTKDSSADRFLSSLGRFMAGLDTKNNVKVWFNNKGWHAISSFLN 1609

  Fly   975 LVYAAI-------GQELAKLDIRIVNKPYQDTVQQAVRGLIYASTIE--FAVLVFHYLVLGTAIF 1030
            ::..||       |:..::..|...|.|...|.||.....:..::::  .::.|...:....|.|
Mouse  1610 VINNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASF 1674

  Fly  1031 AVLPIVERRSKVQHQQFSSGMSRSTYWLSHLSWDYCFYIAMILPLIVV------AGITIGSVLPV 1089
            .|..|.||.||.:|.||.||:....||||:..||.|.|:.....:|::      ......:.|||
Mouse  1675 VVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPV 1739

  Fly  1090 I-VQLLAFGFSAISFTY----LLCLMSNDFGKMFSIILYINMIG-----VLALFIHPKSPQTRYA 1144
            : :.||.:|:|.....|    :..:.|..:..:.|:.|:|.:.|     ||.||.:.|..... .
Mouse  1740 LALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLNDIN-D 1803

  Fly  1145 VIESVLLVHPHYSLCCGMYEAIR----------------MSTFSLKQLPYLIFSGAAYLTIVVFA 1193
            :::||.|:.||:.|..|:.:.::                :|..|...:...:|:.|  :..|||.
Mouse  1804 ILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMA--VEGVVFF 1866

  Fly  1194 WVPRRLNYVFKSIRNEKI---YPSYKDEDKEVDKMRRRLAYLTTAHYAFFPLILKNLSKRY--GS 1253
            .:...:.|.| .||...:   .|...|||::|.:.|:|:......:..   |.:|.|:|.|  ..
Mouse  1867 LITVLIQYRF-FIRPRPVKAKLPPLNDEDEDVRRERQRILDGGGQNDI---LEIKELTKIYRRKR 1927

  Fly  1254 FVAVRSLTLDLNPFECVGLLGRNGSGKSSIFRMIVGMESITVGSIHIKGYSLKTRPKDASRHVGF 1318
            ..||..:.:.:.|.||.||||.||:|||:.|:|:.|...:|.|...:...|:.:...:..:::|:
Mouse  1928 KPAVDRICIGIPPGECFGLLGVNGAGKSTTFKMLTGDTPVTRGDAFLNKNSILSNIHEVHQNMGY 1992

  Fly  1319 CPRELMLLSFMTGKDALRFCCLINGIRREYIKSLVASLAECFELVPHMNKRISTYSNGTKRKLMI 1383
            ||:...:...:||::.:.|..|:.|:..:.:..:.........||.:..|..|.||.|.||||..
Mouse  1993 CPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLST 2057

  Fly  1384 AMGTL-APSLMCLDEPTAGVDMHAKYEIWSILDGIRQGGRSILLTTHNLEECEFLCTNVGIMDHG 1447
            ||..: .|.::.|||||.|:|..|:..:|:....|.:.|||::||:|::||||.|||.:.||.:|
Mouse  2058 AMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGRSVVLTSHSMEECEALCTRMAIMVNG 2122

  Fly  1448 SLLCYGSLSRLKHRFNMGIFVKVKMGTRAEMDDERDNWMQITMMPPNDSEMGSTVGARRMMLAHL 1512
            ...|.||:..||:||..|..:.|::.                         ||            
Mouse  2123 RFRCLGSVQHLKNRFGDGYTIVVRIA-------------------------GS------------ 2150

  Fly  1513 LRHHNPPVEPVKKSRTSRAQPDTTNSELNMRKDYEALLQELEEVFKKDHPYSTVSEKYSYRGMIT 1577
                ||.::||                              :|.|....|.|.:.||  :|.|:.
Mouse  2151 ----NPDLKPV------------------------------QEFFGLAFPGSVLKEK--HRNMLQ 2179

  Fly  1578 FCIPRGQIKWSAIFEYMENLKDEMQILYYSVSHTTFQDVFMKFVRKQN 1625
            :.:|......:.||..:...|..:.|..||||.||...||:.|.:.|:
Mouse  2180 YQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQS 2227

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8908NP_611464.3 rim_protein <124..1626 CDD:130324 439/1803 (24%)
Abca1XP_006537617.1 rim_protein 6..2238 CDD:130324 439/1803 (24%)

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