DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8908 and ABCA9

DIOPT Version :10

Sequence 1:NP_611464.3 Gene:CG8908 / 37293 FlyBaseID:FBgn0034493 Length:1626 Species:Drosophila melanogaster
Sequence 2:XP_024306297.1 Gene:ABCA9 / 10350 HGNCID:39 Length:1634 Species:Homo sapiens


Alignment Length:1793 Identity:387/1793 - (21%)
Similarity:717/1793 - (39%) Gaps:390/1793 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 WLVICKTA-------RFQFSNTLTSVIIIVGPIVVFLVYAATALFREPQEETSVKYPPVNITTKV 75
            |.::||..       |......|.|.:::   :.::|.::......:..:.:|:....|:.....
Human    21 WALLCKNCLKKWRMKRQTLLEWLFSFLLV---LFLYLFFSNLHQVHDTPQMSSMDLGRVDSFNDT 82

  Fly    76 PY-IYYSPENLVLAAVIEDVVHDLKAVGSKAFASASELNKALIGKDTYGYVGIEFDDSFSDINEL 139
            .| |.::||:.....::..|            |||..|.    |:...|:.    |:...|  ||
Human    83 NYVIAFAPESKTTQEIMNKV------------ASAPFLK----GRTIMGWP----DEKSMD--EL 125

  Fly   140 PINVTVGL-------RFPLHLRKNPKMVWDN---------------TSILKHSKMDVDYYQVEGF 182
            .:|.::..       .|..||    |..|.:               .::.:..|.:...:..:||
Human   126 DLNYSIDAVRVIFTDTFSYHL----KFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGF 186

  Fly   183 LVVQAKLSEALIR-AKNEAVV-----LPEVILQHYPDVAEVDRLDNRVALGGV------LFLPVT 235
            :..||.::.|:|. |.|.:|:     :..|.::..|.||:          |||      .|..::
Human   187 VAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQ----------GGVATDFFIFFCIIS 241

  Fly   236 ISA-AYLAQMIVMERRDHLRDMLELMGVRAWIYWLSWFLVAFLLLSIPTVFMVLLLKWRYFSLSD 299
            .|. .|...:.|.:.|.::..::.:||:|...:||||.|:....:.|....|.|::|.....:..
Human   242 FSTFIYYVSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLT 306

  Fly   300 SSLVLFFL-LVYNLEVLTSAFMISSFFSD--TVGVQVAIVIVHLIGCLPWRLLLMGYVPT-LPRT 360
            ..:::|.| |:|.|.::|.||::|.....  ..|:.|.::||.      |.:|....:.| ||..
Human   307 GFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVF------WGILGFPALYTRLPAF 365

  Fly   361 I--FVCLFLNSSLAMGLQQFIKSENLRLGLHWTYLFERTDWDEFVHL----GPIL----LFML-F 414
            :  .:||....:..:|:.|.|         |..|     |.:...||    .|.|    |||| |
Human   366 LEWTLCLLSPFAFTVGMAQLI---------HLDY-----DVNSNAHLDSSQNPYLIIATLFMLVF 416

  Fly   415 GCLLRILVLAYMEQL--RSYQNRKWYFPVQPSFW---CRWNRRPRSDDFDVE------------- 461
            ..||.:::..|.:::  ..|.:|     ..|.|:   |.|.:..|::...:|             
Human   417 DTLLYLVLTLYFDKILPAEYGHR-----CSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCF 476

  Fly   462 --------GQETGIRGHPLIVRARNIEKVF----NEWIAVKDLNLNFYQDEITVFLGHNDSGKST 514
                    |:|.        :|.:|::|.:    ....|:|.:..:.|:.:||..|||:.:||:|
Human   477 EPVSPEFCGKEA--------IRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTT 533

  Fly   515 ILMLLAGFLRPSAGEITINGYDLA--TNQRKARQSMCICPQPNVLFEKVNARWHLQFYCRLKGLN 577
            :|.:|:|...|::|.:|:..:.|:  .:.....:....|||.||.|..:..:.:|:.:.::||:.
Human   534 LLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGIL 598

  Fly   578 RQEASAETDKYLEIGRLQDFANTKVKNLPSGIKRMLMLCCNLCGNSKILLLDEPGTSMDPAMRSN 642
            ..|...|..:.::...:::..:...:||..|..|.|.....:.|:.::||||||...:||..|..
Human   599 PHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHR 663

  Fly   643 MWDLLRRERKGRCIIMATHNMNEAEVVADQIVVLCDAQVIGYGTTGFLTQIAGTGSSYLLICTKM 707
            :|:||:..:..|.|:.:|..::||:::||:.|.:.:.::...|::.||.:..|.|  |.|.....
Human   664 IWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIG--YHLSLHLN 726

  Fly   708 DTCIVAEVTNFLQIRFPDIKLHNEFSIYVTYELPTKYVQQYAALFLELEEALGELNLAEISVCAP 772
            :.|....:|:.::....|.||..:....:.|.||.:...::..|:.:|:....: .:.:..|...
Human   727 ERCDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQ-GIEDYGVSIT 790

  Fly   773 TLGSVFLQM------GEEMRQSWNRISSFDLLSSPSPMLSLLNLLPTF-EVREDDGRVKCCNQWR 830
            ||..|||::      .|.....|.::.: |.......::.|..:|.:| |.|:....|....|..
Human   791 TLNEVFLKLEGKSTIDESDIGIWGQLQT-DGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQV 854

  Fly   831 AIVEKKRLFTLRHQKFYCMIIATPIIICLLIISFSIFIFLVDHHLSELLVTDL--SIYPKAVFVI 893
            ..:.|.|...|:.::.....|       ||:...|....|::|...|......  .:.|...|: 
Human   855 CAIAKVRFLKLKKERKSLWTI-------LLLFGISFIPQLLEHLFYESYQKSYPWELSPNTYFL- 911

  Fly   894 DSPAEGNRFERHYMANVIGQGGTVRSTSGTPIDDYLLA-EMESDQVKVQHTFLAGATFDSNANSI 957
             ||.:..:....::        .|.:.:|:.||::|.: ..::..::|........|.|.:.|..
Human   912 -SPGQQPQDPLTHL--------LVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPSYNGA 967

  Fly   958 IAWSNNKLKHG-----------------SALSMGLVYAAIGQELAKLDIRIVNKPYQDTVQQAVR 1005
            |..|.::..|.                 ..:|.||:......|..:.|.....:.:.|....   
Human   968 IIVSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTDRSTFFEEHMDYEYG--- 1029

  Fly  1006 GLIYASTIEFAVLVFHYLVLG---TAIFAVLPIVERRSKVQHQQFSSGMSRSTYWLSHLSWDYCF 1067
               |.|.      .|.::.:.   |...|:..|.:.:.|...|...||:..|.||......|...
Human  1030 ---YRSN------TFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSL 1085

  Fly  1068 YIAMILPLIVVAGITIGSVLPVIVQ------LLAFGF--SAISFTYLLCLMSNDFGK-------- 1116
            |..::|.:.::..|.....:..|:|      |.:.|:  |.:..||::..:..:..|        
Human  1086 YFLILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFF 1150

  Fly  1117 -----MFSIILY-INMIGVLALFIHPKSPQTRYAVIESVLLVHPHYSLCCGMYEAIRMSTFSLKQ 1175
                 :|||:.. :|..|.|.||.             ..:|: |.::|...::   ..|..|...
Human  1151 FLIVVIFSIVATDLNEYGFLGLFF-------------GTMLI-PPFTLIGSLF---IFSEISPDS 1198

  Fly  1176 LPYLIFSGAA------------YLTIVVFAWVPR-----------RLNYVFK-SIRNEKIYPS-- 1214
            :.||   ||:            ||..::|.::.|           |.:.||: |.|:..|:|:  
Human  1199 MDYL---GASESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPE 1260

  Fly  1215 ---YKDEDKEVDKMRRRLAYLTTAHYAFFPLIL------------KNLSKRYGSFVAVRSLTLDL 1264
               .::||.::::||...| :....:...|:|:            ||...:....:|.|:::..:
Human  1261 EPEGEEEDIQMERMRTVNA-MAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCV 1324

  Fly  1265 NPFECVGLLGRNGSGKSSIFRMIVGMESITVGSIHIKGYSLKTRPKDASRHVGFCPRELMLLSFM 1329
            ...|.:||||.||:|||:..:||.|....|.|.:.:||    :...:....:|:||:|..|...:
Human  1325 KKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKG----SGGGEPLGFLGYCPQENALWPNL 1385

  Fly  1330 TGKDALRFCCLINGIRREYIKSLVASLAECFELVPHMNKRISTYSNGTKRKLMIAMGTLA-PSLM 1393
            |.:..|.....:.|:|:......:..|.:..:|...:...:.|.|.|.||||...:..|. ||::
Human  1386 TVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPSVV 1450

  Fly  1394 CLDEPTAGVDMHAKYEIWSILDG-IRQGGRSILLTTHNLEECEFLCTNVGIMDHGSLLCYGSLSR 1457
            .||||:.|:|...:.::|.::.. .|...|..|||||.:.|.|.:|..|.||..|.|.|.||:..
Human  1451 LLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQH 1515

  Fly  1458 LKHRFNMGIFVKVKMGTRAEMDDERDNWMQITMMPPNDSEMGSTVGARRMMLAHLLRHHNPPVEP 1522
            ||.:|.....:::|:...|:|                                            
Human  1516 LKSKFGKDYLLEMKLKNLAQM-------------------------------------------- 1536

  Fly  1523 VKKSRTSRAQPDTTNSELNMRKDYEALLQELEEVFKKDHPYSTVSEKYSYRGMITFCIPRGQIK- 1586
                                    |.|..|:..:|    |.:...|::|  .::.:.:|...:: 
Human  1537 ------------------------EPLHAEILRLF----PQAAQQERFS--SLMVYKLPVEDVRP 1571

  Fly  1587 WSAIFEYMENLKDEMQILYYSVSHTTFQDVFMKFVRKQ 1624
            .|..|..:|.:|....:..||:|.:|.:.||::..::|
Human  1572 LSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQ 1609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8908NP_611464.3 rim_protein <124..1626 CDD:130324 367/1679 (22%)
ABCA9XP_024306297.1 ABC2_membrane_3 53..416 CDD:463674 92/418 (22%)
rim_protein <245..1609 CDD:130324 337/1528 (22%)

Return to query results.
Submit another query.