DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsl and nceh1b.1

DIOPT Version :9

Sequence 1:	NP_611463.1	Gene:	Hsl / 37289	FlyBaseID:	FBgn0034491	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_001071229.1	Gene:	nceh1b.1 / 777713	ZFINID:	ZDB-GENE-061110-43	Length:	408	Species:	Danio rerio

Alignment Length:	439	Identity:	100/439 - (22%)
Similarity:	147/439 - (33%)	Gaps:	171/439 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 HCHGGGFVAQSSKSHELYLR--DWAVALDCPILSVDYSLAPEAPFPRALQEVYYAYCWLLNNTEL 459
            :.||||:...|:|....||:  :.|..||..:|||:|.|||:..||....:|:.|...:| ..|:
Zfish   110 YLHGGGWTVGSAKMEAYYLQCMEMAKQLDAVVLSVEYRLAPDGRFPDQYNDVFQAAKHIL-TAEV 173

  Fly   460 LGTTA---ERVVCAGDSAGANLSIGVALKCIEQGVRVPDGLFLAYCPTLVSFVPSPARLLCLMDP 521
            |...:   :||..:|||||.||:..||     |.:.|.            |.||...:|..|:.|
Zfish   174 LSRYSIDPKRVAVSGDSAGGNLAAAVA-----QQMAVD------------SSVPIKFKLQALIYP 221

  Fly   522 LLPFGFMMRCLRAYAAPAQETLQQNAKQVEDAAQIRNVPKSNVGSLNSSRRTSMARSPLSPLEAS 586
            :|. |.      .:..|   :.||||                        .|.:...||
Zfish   222 VLQ-GL------DFNTP---SYQQNA------------------------FTPILYRPL------ 246

  Fly   587 MNPDDESSDTFASASASYHSQTVERTDLPHTEGDNSSCVSFEDDSQPIVHYPIEISADP-PKDTA 650
                                  :.|..|.:..|        |....|.:...|:.:.|. ||..|
Zfish   247 ----------------------MARFWLEYLNG--------EQILLPTMLANIQSAQDQGPKIEA 281

  Fly   651 SAAYIDNFLDKYLIDTATMEVTEETAPEAVQAQANGHAKISSDDDILVETGRDLVAIDTLQGRLQ 715
            :.|.||..|   |:..|..:..:..:|      .:|..|:                ::.|.|.|
Zfish   282 ARAKIDWTL---LLPVAFQKSYKPVSP------LHGDPKL----------------LEKLPGLL- 320

  Fly   716 EAVNNITNTLTRCTQSYEIHGSNVMAQQDVRNMDALIARSPSEEFAFDVPKDPFLSPYWASDEWL 780
                                        |||                       .:|..|..|.|
Zfish   321 ----------------------------DVR-----------------------AAPLLAESEVL 334

  Fly   781 SQLPETKILTLNMDPCLDDCVMFAKKLKRLGRQVDLEILEGLPHGFLNF 829
            ..:|...|:|...|...||.:|:|.:|::.|..|.|:..|...||.|:|
Zfish   335 KAVPPAYIMTCEHDVLRDDGLMYATRLQQAGVHVYLDHYEDGFHGCLSF 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsl	NP_611463.1	HSL_N	51..376	CDD:283906
		Aes	350..>537	CDD:223730	46/144 (32%)
		Abhydrolase	395..>539	CDD:304388	46/146 (32%)
		Abhydrolase	<767..827	CDD:304388	19/59 (32%)
nceh1b.1	NP_001071229.1	Aes	88..408	CDD:223730	100/439 (23%)
nceh1b.1	NP_001071229.1	Abhydrolase_3	108..382	CDD:285143	98/436 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0657
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263520at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820