DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsl and lipe

DIOPT Version :9

Sequence 1:	NP_611463.1	Gene:	Hsl / 37289	FlyBaseID:	FBgn0034491	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	XP_012822152.2	Gene:	lipe / 733899	XenbaseID:	XB-GENE-988272	Length:	863	Species:	Xenopus tropicalis

Alignment Length:	890	Identity:	284/890 - (31%)
Similarity:	418/890 - (46%)	Gaps:	184/890 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 AACQDHAAFFARDHTEFGQRLHAAHIAWQDFIVLANRLVQQIDAFAHEYDFDEQTPGNGYRSFIY 120
            |.|.::.:.|....:|.|.||..|....|:.|......::.:.|....:|.|..||.|||||.:.
Frog    38 ALCDENISHFGESSSEVGSRLVQAFSRIQEQIREIEPALRALAAVCPLFDLDPSTPANGYRSLMK 102

  Fly   121 VTNACIAHGISICQQLTATRSTIFFRKKFYMKEVEACS----QLLSSLCTCLQYLLILRQWSAST 181
            |..:|..:.:..|:.:|..|.::|||......|:||..    ||.:.||.. |.||...|    .
Frog   103 VVLSCTQYILHKCRYVTDNRRSLFFRAAHNCSELEAYGSALIQLRALLCFA-QRLLTANQ----H 162

  Fly   182 GDLFACGNH-TAEQLFELGDTINQYCFYGRCLGFQYGDSIRGVLRFLGISMASYSESYYSQE--- 242
            ||||..... .:|:......|:::.||||||||||:..|||..|:.:.|.:.|:.|:|...|
Frog   163 GDLFFWQERGLSEEFLREYSTMHKGCFYGRCLGFQFTPSIRPFLQTISIGLVSFGENYKRHESGI 227

  Fly   243 GDGPIVK----TTRSLWTSGKYLMNPELRARRIVNISQNAKIDFCKSFWFLAESEMMHKLPSIVG 303
            .:|.|..    ...|.:.||:|.::||||......|:||..::|.|:||.:.|.|::..:..|..
Frog   228 NEGAIGTYYGVAASSFFISGRYAIDPELRGAEFERITQNLDVNFWKTFWNITEMEVLTSIVGIAS 292

  Fly   304 SSIKVNRLIELPAEPLKLPRRKNFKASDNLSSDVNQNQGDGDFVEIPVPTAHLGPGLPVSVRLLS 368
            :::::|:.:.:|.|||::|          |.||....      |.|..|.||.||| ||.:||:|
Frog   293 TNVRINKCLSVPPEPLEMP----------LYSDPRLT------VTINPPVAHTGPG-PVHMRLIS 340

  Fly   369 ARRRSG---------MLGEG------RYRGWHKPIPPSPSILFHCHGGGFVAQSSKSHELYLRDW 418
            .:.|.|         |..||      |.|.  :|.|.||.::.|.||||||||:|||||.|||.|
Frog   341 YQLREGQESEQLSALMKPEGPLSIDLRLRS--RPAPLSPDLIIHFHGGGFVAQTSKSHEPYLRTW 403

  Fly   419 AVALDCPILSVDYSLAPEAPFPRALQEVYYAYCWLLNNTELLGTTAERVVCAGDSAGANLSIGVA 483
            |..|:.|||||||||||||||||||:|.:|||||.|.|..|||:|||||..||||||.||.|.|:
Frog   404 AQELEAPILSVDYSLAPEAPFPRALEECFYAYCWALKNCRLLGSTAERVCLAGDSAGGNLCITVS 468

  Fly   484 LKCIEQGVRVPDGLFLAYCPTLVSFVPSPARLLCLMDPLLPFGFMMRCLRAYAAPAQETLQQNAK 548
            |:....|:|:|||:..||..||:....||:|||.|||||||...:.:||.|||...:..:.:.|.
Frog   469 LRAASVGIRMPDGIMAAYPATLLQATASPSRLLTLMDPLLPLSVLSKCLSAYAGTERVPIDERAL 533

  Fly   549 QVEDAAQ---------IRNVPKSNVGSLNS------------SRRTSMARSPLSPLEASMNPDDE 592
            :.:.|..         :|::.:.....|:|            :.|||::.:.|:         :|
Frog   534 EKQSALSQVKRGTALFLRDIRQGATSWLSSFMDGKKEKGNLETMRTSVSEAALT---------EE 589

  Fly   593 SSDTFASASASYHSQTVERTDLPHTEGDNSSCVSFEDDS--------------------QPIVHY 637
            |:..|..:..|...|.:.|......:|:.:..::....|                    :|:...
Frog   590 STAHFRGSLKSKTCQDLSRHQYVEQDGNQNQHLTQNKHSLKSHKQNTAKGLQNGCGNVQRPLSTL 654

  Fly   638 PIEISADPPKDTASAAYIDNFLDKYLIDTATMEVTEETAPEAVQAQANGHAKISSDDDILVETGR 702
            |::    |.:|.                      ||:.:|.:.|.|........|:.|
Frog   655 PVQ----PGQDG----------------------TEQLSPLSPQMQGGSFFLSESESD------- 686

  Fly   703 DLVAIDTLQGRLQEAVNNITNTLTRCTQSYE-IH------------GSN---------VMAQQDV 745
                               ::|..:|.:... ||            ||.         :.:|..|
Frog   687 -------------------SDTSGQCLKGESPIHLKENIPPFHSSEGSTLGFPEGFQPLRSQNGV 732

  Fly   746 RNMDALIARSPSEEFAFDVPKDPFLSPYWASDEWLSQLPETKILTLNMDPCLDDCVMFAKKLKRL 810
            .||....:.         :..:|::||..|.|..|..||...|:...:||.|||.|||||:|:.|
Frog   733 ANMTLQTSA---------IVHNPYMSPLLAPDNMLQGLPPIHIVACALDPMLDDSVMFAKRLRAL 788

  Fly   811 GRQVDLEILEGLPHGFLNFTMLSNEAMEGSKKCIKSLQTLLQTDS 855
            .|.|.|:::|.||||||:.:.||.|..|.:..|::.::.:|..::
Frog   789 NRPVTLQVVENLPHGFLSLSQLSRETREATAVCVQCIRQVLHNEA 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsl	NP_611463.1	HSL_N	51..376	CDD:283906	108/340 (32%)
		Aes	350..>537	CDD:223730	113/201 (56%)
		Abhydrolase	395..>539	CDD:304388	92/143 (64%)
		Abhydrolase	<767..827	CDD:304388	29/59 (49%)
lipe	XP_012822152.2	HSL_N	32..347	CDD:399389	107/330 (32%)
		Abhydrolase	380..>522	CDD:419691	91/141 (65%)
		Abhydrolase	<743..805	CDD:419691	29/61 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3189
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1862
OMA	1	1.010	-	-		QHG48026
OrthoDB	1	1.010	-	-		D1263520at2759
OrthoFinder	1	1.000	-	-		FOG0006107
OrthoInspector	1	1.000	-	-		oto105366
Panther	1	1.100	-	-	LDO	PTHR23025
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4404
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080