Protein Alignment Hsl and Aadac

DIOPT Version :9

• Sequence 1: NP_611463.1
• Gene: Hsl / 37289
• FlyBaseID: FBgn0034491
• Length: 881
• Species: Drosophila melanogaster
• Sequence 2: NP_075872.1
• Gene: Aadac / 67758
• MGIID: 1915008
• Length: 398
• Species: Mus musculus
• Alignment Length: 488
• Identity: 102/488 - (20%)
• Similarity: 153/488 - (31%)
• Gaps: 199/488 - (40%)

  Fly   362 VSVRLLSARRRSGMLGEGRYRGWHKPIPPSPSILFHCHGGGFVAQSSKSHELY--LRDW-AVALD 423
            |.||:...:|:|..|..|               ||:.||||: ...|.:|..|  |..| |..||
Mouse    88 VPVRIYIPKRKSMALRRG---------------LFYIHGGGW-CLGSAAHFSYDTLSRWTAHKLD 136

  Fly   424 CPILSVDYSLAPEAPFPRALQEVYYAYCWLLNN--TELLGTTAERVVCAGDSAGANLSIGVALKC 486
            ..::|.||.|||:..|||..::||.:..|.|..  .|..|....||..:|||||.||:..|..:.
Mouse   137 AVVVSTDYGLAPKHHFPRQFEDVYRSLRWFLQEDVLEKYGVDPRRVGVSGDSAGGNLAAAVTQQL 201

  Fly   487 IEQGVRVPDGLFLAYCPTLVSFVPSPARLLCLMDPLLPFGFMMRCLRAYAAPAQETLQQNAKQVE 551
            |:                               ||.:.....::.|...|..|.:|
Mouse   202 IQ-------------------------------DPDVKIKLKVQALIYPALQALDT--------- 226

  Fly   552 DAAQIRNVPKSNVGSLNSSRRTSMARSPLSPLEASMNPDDESSDTFASASASYHSQTVERTDLPH 616
                  |||....||
Mouse   227 ------NVPSQQEGS-------------------------------------------------- 235

  Fly   617 TEGDNSSCVSFEDDSQPIVHYPIEISADPPKDTASAAYIDNFLDKYLIDTATMEVTEETAPEAVQ 681
                               |:|:          .:.:.:..|..:|.       .|:....:|:
Mouse   236 -------------------HFPV----------LTRSLMVRFWSEYF-------TTDRGLEKAM- 263

  Fly   682 AQANGHAKISSDDDILVETGRDLVAIDTLQGRLQEAVNNITNTLTRCTQSYEIHGSNVMAQQDVR 746
             ..|.|..:.|                   ..|.:.||                .|:::.:   |
Mouse   264 -LLNQHVPMES-------------------SHLLQFVN----------------WSSLLPE---R 289

  Fly   747 NMDALIARSP---SEEFAFDVPK--DPFLSPYWASDEWLSQLPETKILTLNMDPCLDDCVMFAKK 806
            ...:.:.::|   |.|.|...|.  |....|..|:|..|..||:|.|:|...|...||.:|:.|:
Mouse   290 YKKSPVYKNPTPGSSELAQKYPGFIDVKACPLLANDNILHHLPKTYIITCQYDVLRDDGLMYVKR 354

  Fly   807 LKRLGRQVDLEILEGLPHGFLNFTMLS-NEAME 838
            |:.:|..|....:|...||..:|..|. :|.|:
Mouse   355 LQNVGVHVTHHHVEDGFHGTFSFPGLKLSERMK 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsl	NP_611463.1	HSL_N	51..376	CDD:283906	5/13 (38%)
		Aes	350..>537	CDD:223730	50/179 (28%)
		Abhydrolase	395..>539	CDD:304388	44/148 (30%)
		Abhydrolase	<767..827	CDD:304388	21/59 (36%)
Aadac	NP_075872.1	Aes	26..373	CDD:223730	96/472 (20%)
		Abhydrolase_3	106..356	CDD:285143	85/422 (20%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	110..112		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0657
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263520at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820