Protein Alignment Hsl and Aadac

DIOPT Version :10

• Sequence 1: NP_611463.1
• Gene: Hsl / 37289
• FlyBaseID: FBgn0034491
• Length: 881
• Species: Drosophila melanogaster
• Sequence 2: NP_065413.1
• Gene: Aadac / 57300
• RGDID: 631440
• Length: 398
• Species: Rattus norvegicus
• Alignment Length: 503
• Identity: 99/503 - (19%)
• Similarity: 150/503 - (29%)
• Gaps: 209/503 - (41%)

  Fly   334 SSDVNQNQGDGDFVEIPVPTAHLGPGLPVSVRLLSARRRSGMLGEGRYRGWHKPIPPSPSILFHC 398
            :||.|....:.||..:|             ||:...:|:|..|..|               ||..
  Rat    73 TSDENVTVMETDFNSVP-------------VRIYIPKRKSTTLRRG---------------LFFI 109

  Fly   399 HGGGFVAQSSK--SHELYLRDWAVALDCPILSVDYSLAPEAPFPRALQEVYYAYCWLLNN--TEL 459
            ||||:...|:.  .::...|..|..||..::|.||.|||:..||:..::||::..|.|..  .|.
  Rat   110 HGGGWCLGSAAYFMYDTLSRRTAHRLDAVVVSTDYGLAPKYHFPKQFEDVYHSLRWFLQEDILEK 174

  Fly   460 LGTTAERVVCAGDSAGANLSIGVALKCIEQGVRVPDGLFLAYCPTLVSFVPSPARLLCLMDPLLP 524
            .|....||..:|||||.||:..|..:                               .|.||.:.
  Rat   175 YGVDPRRVGVSGDSAGGNLTAAVTQQ-------------------------------ILQDPDVK 208

  Fly   525 FGFMMRCLRAYAAPAQETLQQNAKQVEDAAQIRNVPKSNVGSLNSSRRTSMARSPLSPLEASMNP 589
            ....::.|   ..||.:.|..            |||
  Rat   209 IKLKVQAL---IYPALQALDM------------NVP----------------------------- 229

  Fly   590 DDESSDTFASASASYHSQTVERTDLPHTEGDNSSCVSFEDDSQPIVHYPIEISADPPKDTASAAY 654
                                                |.:::||    ||:          .:.:.
  Rat   230 ------------------------------------SQQENSQ----YPL----------LTRSL 244

  Fly   655 IDNFLDKYLIDTATMEVTEETAPEAVQAQANGHAKISSDDDILVETGRDLVAIDTLQGRLQEAVN 719
            :..|..:|.                                   .|.|||.....|...:....:
  Rat   245 LIRFWSEYF-----------------------------------TTDRDLEKAMLLNQHVPVEFS 274

  Fly   720 NITNTLTRCTQSYEIHGSNVMAQQDVRNMDALIARSP---SEEFAFDVP--KDPFLSPYWASDEW 779
            ::...         ::.|:::.|   |.......::|   |.|.|...|  .|....|..|:|..
  Rat   275 HLLQF---------VNWSSLLPQ---RYKKGYFYKTPTPGSLELAQKYPGFTDVKACPLLANDSI 327

  Fly   780 LSQLPETKILTLNMDPCLDDCVMFAKKLKRLGRQVDLEILEGLPHGFL 827
            |..||.|.|:|...|...||.:|:.|:|:..|..|....:|...||.|
  Rat   328 LHHLPMTYIITCQYDVLRDDGLMYVKRLQNTGVHVTHHHIEDGFHGAL 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsl	NP_611463.1	HSL_N	51..376	CDD:461882	10/41 (24%)
		alpha/beta hydrolases	395..>539	CDD:473884	39/147 (27%)
		Aes	<767..838	CDD:440422	22/61 (36%)
Aadac	NP_065413.1	Abhydrolase_3	106..373	CDD:400284	84/438 (19%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	110..112		1/1 (100%)