DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsl and nceh1a

DIOPT Version :9

Sequence 1:	NP_611463.1	Gene:	Hsl / 37289	FlyBaseID:	FBgn0034491	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_001002303.1	Gene:	nceh1a / 432374	ZFINID:	ZDB-GENE-040711-2	Length:	407	Species:	Danio rerio

Alignment Length:	444	Identity:	88/444 - (19%)
Similarity:	137/444 - (30%)	Gaps:	175/444 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 SILFHCHGGGFVAQSSK--SHELYLRDWAVALDCPILSVDYSLAPEAPFPRALQEVYYAYCWLLN 455
            :::| .||||:...:.|  |::...|..:..|:..:::|||.:||:..||...:|...|...||
Zfish   107 AVMF-IHGGGWSLGAPKLGSYDSLCRQMSADLNAVVVTVDYRMAPDVHFPVQYEECVQAAKHLL- 169

  Fly   456 NTELL---GTTAERVVCAGDSAGANLSIGVALKCIEQGVRVPDGLFLAYCPTLVSFVPSPARLLC 517
            ..|:|   ....|||...|||||.||:..||.:...:.            .|...|     :|..
Zfish   170 KPEVLKQYSVDPERVAVCGDSAGGNLAAAVAQRIGTEN------------STSAKF-----KLQV 217

  Fly   518 LMDPLLPFGFMMRCLRAYAAPAQETLQQNAKQVEDAAQIRNVPKSNVGSLNSSRRTSMARSPLSP 582
            |:.|:|                 :.|..|....:   |..|||        ...|..|||..|..
Zfish   218 LIYPVL-----------------QALDFNTASYQ---QNHNVP--------ILYRRLMARFWLEY 254

  Fly   583 LEASMNPDDESSDTFASASASYHSQTVERTDLPHTEGDNSSCVSFEDDSQPIVHYPIEISADPPK 647
            |                                                          .|||
Zfish   255 L----------------------------------------------------------GADP-- 259

  Fly   648 DTASAAYIDNFLDKYLIDTATMEVTEETAPEAVQAQANGHAKISSDDDILVETGRDLVAIDTLQG 712
                                      |.|...:.   |.|   ::.|..|:...|
Zfish   260 --------------------------ELAHSIMM---NNH---TAQDQNLLSQNR---------- 282

  Fly   713 RLQEAVNNITNTLTRCTQSYEIHGSNVMAQQDVRNMDALIARSPSEEFAFDVP--KDPFLSPYWA 775
                               .::..:|::.::..::...:...:.|.....|||  .|...||..|
Zfish   283 -------------------AKLDWTNLLPKEIRKHFKPVFPVTGSPNILSDVPGLLDSRASPLLA 328

  Fly   776 SDEWLSQLPETKILTLNMDPCLDDCVMFAKKLKRLGRQVDLEILEGLPHGFLNF 829
            .||.|...|...|:|...|...||.:|:|::|:..|..|..:..:...||.::|
Zfish   329 EDEVLRMAPRAYIMTGEHDVLRDDGMMYARRLELAGVSVTNDHYQDGFHGCVSF 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsl	NP_611463.1	HSL_N	51..376	CDD:283906
		Aes	350..>537	CDD:223730	40/148 (27%)
		Abhydrolase	395..>539	CDD:304388	40/148 (27%)
		Abhydrolase	<767..827	CDD:304388	20/59 (34%)
nceh1a	NP_001002303.1	Abhydrolase	29..>147	CDD:304388	11/40 (28%)
		Aes	88..378	CDD:223730	85/438 (19%)
		Abhydrolase_3	108..378	CDD:285143	85/437 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0657
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263520at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820